Proloprim (Trimethoprim) - Summary

PROLOPRIM SUMMARY

PROLOPRIM^® (trimethoprim)
-mg and 200-mg Scored Tablets

PROLOPRIM (trimethoprim) is a synthetic antibacterial available in tablet form for oral administration.

Proloprim (trimethoprim) is indicated for the following:

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus.

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.

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PROLOPRIM NEWS HIGHLIGHTS

Published Studies Related to Proloprim (Trimethoprim)

Trimethoprim-sulfamethoxazole in children with chronic otitis media: a randomized comparison of costs and effects. [2008.10]

Randomized controlled trial of pyrimethamine plus sulfadiazine versus trimethoprim plus sulfamethoxazole for treatment of toxoplasmic encephalitis in AIDS patients. [2008.03]

Simultaneous determination of sulfamethoxazole and trimethoprim in biological fluids for high-throughput analysis: comparison of HPLC with ultraviolet and tandem mass spectrometric detection. [2008.02.15]

Oral ciprofloxacin or trimethoprim reduces bacteriuria after flexible cystoscopy. [2007.10]

Randomized Controlled Trial of Pyrimethamine Plus Sulfadiazine Versus Trimethoprim Plus Sulfamethoxazole for Treatment of Toxoplasmic Encephalitis in AIDS Patients. [2007.05.21]

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Clinical Trials Related to Proloprim (Trimethoprim)

A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS [Completed]

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa [Completed]

Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS [Completed]

A Pilot Study of Oral Tinidazole for Women With Recurrent Bacterial Vaginosis [Terminated]

Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis [Completed]

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PROLOPRIM PATIENT REVIEWS / RATINGS / COMMENTS

Proloprim review by 33 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		Mild Side Effects
		Treatment Info
Condition / reason:		acne
Dosage & duration:		100mg taken 2x daily initially, 1x daily maintenance for the period of over 4 years
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		Dermatologist suggested trial of trimethoprim 2x per daily, once morning and once in the evening. Diminished acne resulted within the first month and more significantly for the following months. After 1 year, patient reduced to taking pill once per day.
Side effects:		Side effects were mild, but a similar derivative had significant side effects so this patient recommends trying another sulfur-based drug if this once poses problems. Side effects with trimethoprim included very mild sun sensitivity-simply use a sunscreen; occasional yeast infections once or twice per year; upset stomach if taken without food.
Comments:		Patient suffered acne for over 15 years and had been treated with various oral and topical medications. Oral medications included most typical antibiotics and Accutane. Results were less than ideal. D