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Prolixin (Fluphenazine Decanoate) - Summary



Fluphenazine Hydrochloride Oral Solution USP

Prolixin Decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect. Prolixin Decanoate is available for intramuscular or subcutaneous administration, providing 25 mg fluphenazine decanoate per mL in a sesame oil vehicle with 1.2% (w/v) benzyl alcohol as a preservative. At the time of manufacture, the air in the vials is replaced by nitrogen.

PROLIXIN (fluphenazine) is indicated for the following:

Prolixin Decanoate (Fluphenazine Decanoate Injection) is a long-acting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy (e.g., chronic schizophrenics).

Prolixin Decanoate has not been shown effective in the management of behavioral complications in patients with mental retardation.

See all Prolixin indications & dosage >>


Media Articles Related to Prolixin (Fluphenazine)

Repeated traumatic experiences throughout infancy multiplies by 7 the risk of psychosis
Source: Anxiety / Stress News From Medical News Today [2016.02.01]
50 pairs of siblings (one of them suffered psychosis while the other didn't) participated in this research, published in the renowned Journal of Psychiatric Research magazineA research carried...

Team-based treatment for first episode psychosis found to be high value
Source: Mental Health News From Medical News Today [2016.02.01]
NIH-funded study shows early intervention is more cost-effective than typical care.

Suffering repeated traumatic experiences throughout infancy and adolescence multiplies by 7 the risk of suffering psychosis during adulthood
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2016.01.30]
A research carried out with participation of the University of Granada (UGR) proves that suffering repeated traumatic experiences throughout infancy and adolescence multiplies by 7 the risk of...

UTSW-led study establishes biomarkers to help diagnose, treat psychosis
Source: Bipolar News From Medical News Today [2015.12.08]
In a groundbreaking study led by UT Southwestern Medical Center, a comprehensive set of empirical biomarkers has been established to aid in diagnosis and treatment of psychosis.

Should Psychiatry Dump Schizophrenia From the Lexicon?
Source: MedPage Today Neurology [2016.02.04]
(MedPage Today) -- A growing movement seeks to formalize psychosis as a spectrum disorder

more news >>

Published Studies Related to Prolixin (Fluphenazine)

The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study. [2007.03.30]
Pharmacotherapy of schizophrenia is associated with the stressful side effects...

A randomized double-blind 12-week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia. [2006.04]
Sexual dysfunction is common in people suffering from schizophrenia and is reported by patients to be a significant reason for medication nonadherence. This report contains data for 27 people with schizophrenia who participated in a randomized double-blind 12-week trial of risperidone (4 mg/day), quetiapine (400 mg/day) or fluphenazine (12.5 mg/day)...

Risperidone, quetiapine, and fluphenazine in the treatment of patients with therapy-refractory schizophrenia. [2005.07]
This 12-week, double-blind study evaluated the effectiveness of risperidone (4 mg/day), quetiapine (400 mg/day), or fluphenazine (12.5 mg/day) in a stringently defined treatment-resistant population of people with schizophrenia. No differences were noted in total Brief Psychiatric Rating Scale (BPRS) or Clinical Global Impression scores among the drug groups (n = 38)...

Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. [2005.01]
CONCLUSIONS: It is expected that TT(4) levels will decrease during quetiapine treatment, and this may possibly be related to competitive metabolism of thyroid hormones and quetiapine by UDP-glucuronosyltransferase. Routine monitoring of thyroid function in quetiapine-treated patients without a history of thyroid disease is not recommended.

Fluphenazine decanoate (depot) and enanthate for schizophrenia. [2015]
CONCLUSIONS: There are more data for fluphenazine decanoate than for the

more studies >>

Clinical Trials Related to Prolixin (Fluphenazine)

Study of Fluphenazine in Relapsed or Relapsed-and-Refractory Multiple Myeloma [Recruiting]
The purpose of this study is to evaluate the safety and tolerability of fluphenazine in patients with advanced multiple myeloma. The study will also describe the efficacy of this drug.

Fluphenazine Hydrochloride for Psoriasis [Completed]
The objective of this study is to assess the safety and biologic activity of intralesional injection of fluphenazine in adult subjects with psoriasis.

Fluphenazine Decanoate for Psoriasis [Terminated]
We are doing this research study to evaluate the effectiveness and safety of fluphenazine decanoate when injected with a needle into psoriasis lesions in adults. Fluphenazine decanoate is FDA (U. S. Food and Drug Administration) approved for use in people who have schizophrenia and psychotic symptoms. Fluphenazine decanoate is not approved by the FDA for use in psoriasis. Fluphenazine decanoate slows T cell growth in cells in laboratory test tubes. Its usefulness and safety in people with psoriasis will be investigated in this study.

D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement [Active, not recruiting]
To determine if: 1. pathological gambling is similar to psychostimulant addiction as reflected by parallel roles for D1 and D2 receptors in gambling and stimulant reinforcement. 2. these parallel roles are linked with gambling pathology or if they are evident in both gamblers and controls.

Fluphenazine in Treating Patients With Refractory Advanced Multiple Myeloma [Completed]
RATIONALE: Drugs used in chemotherapy, such as fluphenazine, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. PURPOSE: This phase I/II trial is studying the side effects and best dose of fluphenazine and to see how well it works in treating patients with refractory advanced multiple myeloma.

more trials >>

Reports of Suspected Prolixin (Fluphenazine) Side Effects

Delusion (3)Neuroleptic Malignant Syndrome (3)Hypersensitivity (2)Drug Interaction (2)Cardiac Disorder (2)Brain Injury (2)Weight Increased (2)Overdose (2)Myocardial Infarction (2)Tardive Dyskinesia (2)more >>

Page last updated: 2016-02-04

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