NEWS HIGHLIGHTSMedia Articles Related to Prolixin (Fluphenazine)
Early Cognitive Behavioural Therapy Reduces Risk Of Psychosis
Source: Mental Health News From Medical News Today [2013.04.23]
Young people seeking help who are at high risk of developing psychosis could significantly reduce their chances of going on to develop a full-blown psychotic illness by getting early access to cognitive behavioural therapy (CBT), new research shows...
In The Brain High Levels Of Glutamate May Kick-Start Schizophrenia
Source: Anxiety / Stress News From Medical News Today [2013.04.22]
An excess of the brain neurotransmitter glutamate may cause a transition to psychosis in people who are at risk for schizophrenia, reports a study from investigators at Columbia University Medical Center (CUMC) published in the current issue of Neuron...
New Gene Variant May Explain Psychotic Features In Bipolar Disorder
Source: Bipolar News From Medical News Today [2013.03.06]
Researchers at Karolinska Institutet in Sweden have found an explanation for why the level of kynurenic acid (KYNA) is higher in the brains of people with schizophrenia or bipolar disease with psychosis. The study, which is published in the scientific periodical Molecular Psychiatry, identifies a gene variant associated with an increased production of KYNA...
Published Studies Related to Prolixin (Fluphenazine)
The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study. [2007.03.30]
Pharmacotherapy of schizophrenia is associated with the stressful side effects...
A randomized double-blind 12-week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia. [2006.04]
Sexual dysfunction is common in people suffering from schizophrenia and is reported by patients to be a significant reason for medication nonadherence. This report contains data for 27 people with schizophrenia who participated in a randomized double-blind 12-week trial of risperidone (4 mg/day), quetiapine (400 mg/day) or fluphenazine (12.5 mg/day)...
Risperidone, quetiapine, and fluphenazine in the treatment of patients with therapy-refractory schizophrenia. [2005.07]
This 12-week, double-blind study evaluated the effectiveness of risperidone (4 mg/day), quetiapine (400 mg/day), or fluphenazine (12.5 mg/day) in a stringently defined treatment-resistant population of people with schizophrenia. No differences were noted in total Brief Psychiatric Rating Scale (BPRS) or Clinical Global Impression scores among the drug groups (n = 38)...
Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine. [2005.01]
CONCLUSIONS: It is expected that TT(4) levels will decrease during quetiapine treatment, and this may possibly be related to competitive metabolism of thyroid hormones and quetiapine by UDP-glucuronosyltransferase. Routine monitoring of thyroid function in quetiapine-treated patients without a history of thyroid disease is not recommended.
Effectiveness of switching from long-acting injectable fluphenazine or
haloperidol decanoate to long-acting injectable risperidone microspheres: an
open-label, randomized controlled trial. [2012]
CONCLUSION: Switching from haloperidol decanoate or fluphenazine decanoate to
Clinical Trials Related to Prolixin (Fluphenazine)
Study of Fluphenazine in Relapsed or Relapsed-and-Refractory Multiple Myeloma [Recruiting]
The purpose of this study is to evaluate the safety and tolerability of fluphenazine in
patients with advanced multiple myeloma. The study will also describe the efficacy of this
drug.
Fluphenazine Hydrochloride for Psoriasis [Recruiting]
The objective of this study is to assess the safety and biologic activity of intralesional
injection of fluphenazine in adult subjects with psoriasis.
Fluphenazine Decanoate for Psoriasis [Terminated]
We are doing this research study to evaluate the effectiveness and safety of fluphenazine
decanoate when injected with a needle into psoriasis lesions in adults. Fluphenazine
decanoate is FDA (U. S. Food and Drug Administration) approved for use in people who have
schizophrenia and psychotic symptoms. Fluphenazine decanoate is not approved by the FDA for
use in psoriasis. Fluphenazine decanoate slows T cell growth in cells in laboratory test
tubes. Its usefulness and safety in people with psoriasis will be investigated in this
study.
Fluphenazine in Treating Patients With Refractory Advanced Multiple Myeloma [Completed]
RATIONALE: Drugs used in chemotherapy, such as fluphenazine, work in different ways to stop
the growth of cancer cells, either by killing the cells or by stopping them from dividing.
PURPOSE: This phase I/II trial is studying the side effects and best dose of fluphenazine and
to see how well it works in treating patients with refractory advanced multiple myeloma.
New Antipsychotic Strategies: Quetiapine and Risperidone vs. Fluphenazine in Treatment Resistant Schizophrenia [Active, not recruiting]
The purpose of this study is to:
1. Evaluate the efficacy and safety of the new antipsychotics, quetiapine (300-500mg/day)
and risperidone (3-4mg/day) compared to each other and to fluphenazine (10-15mg/day), a
high potency typical antipsychotic in patients who meet the DSM IV criteria for
schizophrenia.
2. To evaluate the efficacy and safety of quetiapine (1200mg/day) in patients who have not
responded to conventional and newer antipsychotics.
3. To evaluate the effectiveness of quetiapine (300-500mg/day), and risperidone (3-5mg/day)
compared to each other and fluphenazine (10-15mg/day) in the treatment of hostility and
aggression in treatment-resistant schizophrenic patients.
4. To evaluate the effectiveness of quetiapine (300-500mg/day) and risperidone (3-5mg/day)
compared to each other and fluphenazine (10-15mg/day) on rates of discharge, quality of
life, and independent living skills.
5. To assess prolactin levels and to evaluate any relationship with sexual dysfunction and
menstrual irregularities.
6. To evaluate the possible differential impact of treatment conditions on cognitive
functioning including measures of attention, motor speed, problem solving, verbal and
visual memory, and verbal processing speed.
7. To measure changes in weight and health consequences associated with weight changes.
Reports of Suspected Prolixin (Fluphenazine) Side Effects
Delusion (3),
Neuroleptic Malignant Syndrome (3),
Hypersensitivity (2),
Drug Interaction (2),
Cardiac Disorder (2),
Brain Injury (2),
Weight Increased (2),
Overdose (2),
Myocardial Infarction (2),
Tardive Dyskinesia (2), more >>
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