Progesterone injection, a progestin, is a sterile solution of progesterone in a suitable vegetable oil available for intramuscular use. Progesterone occurs as a white or creamy white, crystalline powder. It is odorless and is stable in air. Practically insoluble in water, it is soluble in alcohol, acetone, and dioxane and sparingly soluble in vegetable oils.
This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.
Media Articles Related to Progesterone
Meta-analysis Supports Progesterone for Recurrent Pregnancy Loss
Source: Medscape Nurses Headlines [2017.04.17]
Dr Kovacs summarizes a meta-analysis that evaluated the effectiveness of natural progesterone or synthetic progestogens in women with more than two consecutive pregnancy losses.
Progesterone and bisexuality: Is there a link?
Source: Endocrinology News From Medical News Today [2017.04.05]
Giving progesterone to prevent miscarriage could influence baby's sexual orientation in later life.
Published Studies Related to Progesterone
A randomised controlled double-blind clinical trial of 17-hydroxyprogesterone
caproate for the prevention of preterm birth in twin gestation (PROGESTWIN):
evidence for reduced neonatal morbidity. 
POPULATION: Unselected women with twin pregnancies... CONCLUSIONS: Intramuscular 17OHPC therapy did not reduce PTB before 37 weeks of
Elagolix, an oral GnRH antagonist, versus subcutaneous depot medroxyprogesterone
acetate for the treatment of endometriosis: effects on bone mineral density. 
This randomized double-blind study, with 24-week treatment and 24-week
posttreatment periods, evaluated the effects of elagolix (150 mg every day, 75 mg
twice a day) versus subcutaneous depot medroxyprogesterone acetate (DMPA-SC) on
bone mineral density (BMD), in women with endometriosis-associated pain (n =
Maintenance tocolysis with oral micronized progesterone for prevention of preterm
birth after arrested preterm labor. 
labor... CONCLUSION: Maintenance tocolysis with OMP significantly prolonged pregnancy and
Evaluation of sex, race, body mass index and pre-vaccination serum progesterone
levels and post-vaccination serum anti-anthrax protective immunoglobulin G on
injection site adverse events following anthrax vaccine adsorbed (AVA) in the CDC
AVA human clinical trial. 
site AEs... CONCLUSIONS: Female and non-black participants had a higher proportion of AVA
A four week randomised control trial of adjunctive medroxyprogesterone and
tamoxifen in women with mania. 
Emerging research has suggested that hormone treatments such as selective
oestrogen receptor modulators (SERMs) or progestins may be useful in the
treatment of mania. The current pilot study compared the use of the SERM
tamoxifen and the progestin medroxyprogesterone acetate (MPA), as an adjunct to
mood stabiliser medications, for the treatment of mania symptoms in 51 women in a
28-day double blind, placebo controlled study...
Clinical Trials Related to Progesterone
Uterine Electrical Activity Before and After Progesterone Treatment for Preterm Labor [Recruiting]
This study will examine the effects of various formulations of progesterone on uterine
electromyographic (EMG) activity in pregnant patients in premature labor to determine if
progesterone will suppress uterine electrical activity and which formulation may be best for
inhibition of uterine activity. Patients will be monitored prior to treatment and following
treatment (every 2 to 4 hours) with one of three different formulations of progesterone for
up to two days. Patients will continue to be observed until they deliver. Comparisons will
be for uterine EMG activity from before treatment to that following treatments at 2, 4, 8,
12 24 and 48 hours and times of delivery after treatments (hours or days following
treatments). Comparisons between mean values for EMG activity between the various treatments
at the various times will also be made.
Vaginal Compared to Intramuscular Progesterone for Frozen Embryo Transfer [Not yet recruiting]
Comparing IM vs. Vaginal Progesterone for Pre-term Birth [Completed]
This is a randomized controlled trial comparing weekly intramuscular injection of 17 alpha
hydroxylprogesterone caproate with daily vaginal progesterone in women with singleton
pregnancies and history of prior spontaneous preterm birth in terms of maternal, fetal and
Our aim is to assess the effects on maternal, fetal and neonatal outcomes of antenatal
progesterone administered intramuscularly versus vaginally in women with singleton pregnancy
and a history of prior preterm birth.
Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF) [Completed]
The goal of this research study is to compare the pregnancy rates for two different types of
progesterone supplementation after in-vitro fertilization (IVF).
Optimal Length of Progesterone Supplementation Before the Transfer of Cryopreserved (Frozen)-Thawed Day 3 Embryos in an Artificial Cycle With Exogenous Estrogen and Progesterone [Recruiting]
Cryopreserved-thawed embryos are often replaced in an artificial cycle, in which the
endometrium is prepared by exogenous estrogen and progesterone with or without the use of
GnRH agonist downregulation. The correct duration for exposure to progesterone is still not
well established. To date, there are no prospective randomized trials available, comparing
different durations of progesterone supplementation before the date of transfer, with regard
to treatment outcome (Nawroth).
In this trial, the investigators want to determine the optimal duration of progesterone
supplementation: 3 or 5 days before embryo transfer.
Reports of Suspected Progesterone Side Effects
Foetal Exposure During Pregnancy (14),
Premature Baby (10),
Maternal Exposure During Pregnancy (9),
Death Neonatal (8),
Drug Ineffective (7),
LOW Birth Weight Baby (6),
Abdominal Pain Upper (5), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Progesterone has an overall score of 10. The effectiveness score is 10 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
Progesterone review by 47 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || severe stomach pains, dizziness|
|Dosage & duration:|| || 50 mg taken once a day for the period of 3 months and still one it|
|Other conditions:|| || mood swings|
|Other drugs taken:|| || none|
|Benefits:|| || I have had stomach troubles my entire life. When I was pregnant they were unbearable. I could never take the pill because of nausea. I noticed that when I was 45 the nausea was associated with my cycle, becoming most intense just prior to my period. My gastroenterologist prescribed Nexium, which I took for a year, maximum dosage, daily and then tapered off. Then the other symptoms above emerged. When I started with the progesterone all these symptoms subsided significantly and I rarely ever have stomach problems now. |
|Side effects:|| || None at all that I am aware of.|
|Comments:|| || Prior to taking the oral treatment I used the cream, to avoid the digestive tract altogether. This was fine for about a year, but then the symptoms reappeared. My physician felt that something was interfering with the absorption of the hormones and so prescribed the oral pill and the symptoms have nearly disappeared and I have had no associated stomach problems. I am convinced that much of my stomach problems throughout my life were associated with a hormonal imbalance, but cannot prove this. I do know that this is the best my stomach has ever been in my entire life, for whatever reason.|
Page last updated: 2017-04-17