Progesterone (Progesterone) - Summary

PROGESTERONE SUMMARY

Progesterone injection, a progestin, is a sterile solution of progesterone in a suitable vegetable oil available for intramuscular use. Progesterone occurs as a white or creamy white, crystalline powder. It is odorless and is stable in air. Practically insoluble in water, it is soluble in alcohol, acetone, and dioxane and sparingly soluble in vegetable oils.

This drug is indicated in amenorrhea and abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer.

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NEWS HIGHLIGHTS

Media Articles Related to Progesterone

Hormone Levels And Sexual Motivation Among Young Women
Source: Endocrinology News From Medical News Today [2013.04.29]
Feeling frisky? If so, chances are greater your estrogen level - and, perhaps, fertility - are hitting their monthly peak. If not, you're more likely experiencing a profusion of desire-deadening progesterone, and the less fertile time in your cycle. Oh, the power of hormones...

Overwhelming Evidence Adds A Major New Target In Breast Cancer: Androgens Including Testosterone
Source: Endocrinology News From Medical News Today [2013.04.12]
Estrogen and progesterone receptors, and the gene HER2 - these are the big three markers and/or targets in breast cancer. Evidence presented at the AACR Annual Meeting 2013 adds a fourth: androgen receptors...

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Published Studies Related to Progesterone

Progesterone for premenstrual syndrome. [2012]
CONCLUSIONS: The trials did not show that progesterone is an effective

Progestogen levels, progesterone receptor gene polymorphisms, and mammographic density changes: results from the Postmenopausal Estrogen/Progestin Interventions Mammographic Density Study. [2011.11.18]
OBJECTIVE:: Estrogen plus progestin therapy (EPT) in postmenopausal women increases breast cancer risk and mammographic density to a higher extent than does estrogen therapy alone. Data from the randomized placebo-controlled Postmenopausal Estrogen/Progestin Interventions trial showed that EPT-induced increases in serum estrone and estrone sulfate levels were positively correlated with increases in mammographic density. Here, after adjusting for serum estrone and estrone sulfate levels, we investigated the roles of posttreatment serum progestogen increase and of progesterone receptor gene (PGR) genetic variations on changes in mammographic density... CONCLUSIONS:: Our results suggest that higher serum progestogen levels resulting from EPT treatment lead to greater increases in mammographic density.

[Impacts on the duration of vaginal bleeding and the levels of serum estradiol (E2) and progesterone (P) for patients of midtrimester induction of labor treated with moxibustion at Guanyuan (CV 4) and Shenque (CV 8)]. [2011.09]
OBJECTIVE: To verify the efficacy of moxibustion at Guanyuan (CV 4) and Shenque (CV 8) on the duration of vaginal bleeding for patients with midtrimester induction of labor and explore its mechanism... CONCLUSION: Moxibustion at Guanyuan (CV 4) and Shenque (CV 8) may shorten the duration of vaginal bleeding for patients with midtrimester induction of labor. Probably through the increase of serum E2 level and the decrease of P level, the uterine contraction is effectively enhanced and the excretion of placental villi and deciduas is promoted. As a result, endometrial repair occurs rapidly.

Vaginal micronized progesterone and risk of preterm delivery in high-risk twin pregnancies: secondary analysis of a placebo-controlled randomized trial and meta-analysis. [2011.09]
OBJECTIVES: Progesterone treatment reduces the risk of preterm delivery in high-risk singleton pregnancies. Our aim was to evaluate the preventive effect of vaginal progesterone in high-risk twins... CONCLUSION: In high-risk twin pregnancies, progesterone treatment does not significantly improve outcome. Copyright (c) 2011 ISUOG. Published by John Wiley & Sons, Ltd.

Prevention of preterm delivery in twin gestations (PREDICT): a multicenter, randomized, placebo-controlled trial on the effect of vaginal micronized progesterone. [2011.09]
OBJECTIVE: Studies on high-risk singleton gestations have shown a preventive effect of progesterone treatment on preterm delivery. This study was conducted to investigate the preventive effect of vaginal micronized progesterone in a large population of twin gestations... CONCLUSION: Progesterone treatment did not prevent preterm delivery in twin gestations. There were no harmful effects to fetuses and infants of maternal progesterone treatment. Copyright (c) 2011 ISUOG. Published by John Wiley & Sons, Ltd.

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Clinical Trials Related to Progesterone

Evaluating the Roles of Estrogen and Progesterone in Heart Metabolism [Completed]
Estrogen and progesterone are two main female sex hormones. When a woman goes through menopause, the body's production of estrogen and progesterone significantly decreases. Recent studies have shown that the breakdown of fatty acids in cardiac muscle is important in maintaining a healthy heart, and that estrogen may enhance this process. Also, cardiovascular disease (CVD) occurs more frequently in postmenopausal women than in premenopausal women. This study will determine in postmenopausal women whether estrogen increases the heart's ability to use fats as energy and whether progesterone decreases this effect.

Multi-Center, Randomized, Open-Label, Parallel Group Study of a Vaginal Micronized Progesterone Tablet (Endometrin®) Compared to Crinone 8% Vaginal Gel in Female Patients Undergoing In-Vitro Fertilization (IVF) [Completed]
This multicenter, randomized, open-label study will be performed in approximately 990 healthy females undergoing IVF. Each study center will follow their study center standard practice for IVF unless otherwise noted in this protocol. The study centers will be provided with the medications for down regulation, stimulation and ovulation induction. The subjects will be randomized to study medication on the day of oocyte retrieval or the day following and will continue treatment for up to 10 weeks. The subjects with a confirmed pregnancy will be required to return to the clinic several times during the course of the 10 week treatment period for serum pregnancy tests and transvaginal ultrasounds to monitor the pregnancy.

Artificial Endometrial Preparation for Frozen Thawed Embryo Transfer Applying Either Endometrin or Utrogestan [Suspended]
The transfer of frozen-thawed embryos can be performed in a natural ovulatory cycle or in a hormonally manipulated cycle with a comparable pregnancy rate of 15%-20% per ET. When a hormonally modulated ET cycle is scheduled,an artificial endometrial preparation is carried out using estrogen stimulation followed by a concomitant progesterone treatment. Two progestative drugs are currently used in conventional IVF treatment, Utrogetan and Endometrin. Although Endometrin has been be efficiently used to support the luteal phase after embryo transfer in IVF cycles, currently, there is no study that assess its efficacy for clinical use in frozen-thawed ET cycles. The present study aims to compare the outcome of frozen thawed ET cycles when either Endometrin or Utrogestan are used as the progestative substitution in an artificially prepared endometrium.

Progesterone Reduces Wakefulness in Sleep EEG and Has no Effect on Cognition in Healthy Postmenopausal Women [Completed]
Sleep is impaired in postmenopausal women (difficulty falling asleep, frequent awakenings). Progesterone prompted benzodiazepine-like effects on sleep EEG in young normal male subjects.

Aim of this study was to test if replacement therapy with progesterone improves sleep after menopause.

Design, Setting, and Participants: A double blind cross-over design study with 2 treatment intervals of 21 days duration separated by a 2 weeks washout was performed. A oral dose of 300mg micronized progesterone was given each for 21 days. At the beginning and the end of the two intervals a sleep EEG was recorded and cognitive performance was assessed in 10 healthy postmenopausal women (age: 54-70 yrs).

Vaginal Progesterone as a Treatment for Women Active Preterm Labor [Recruiting]
The purpose of this study is to compare how well vaginal progesterone works delaying the time to delivery in women with preterm labor compared to placebo. The study will also compare the effect of vaginal progesterone on neonatal outcomes, rate of spontaneous preterm delivery, cervical length and biomarkers of preterm delivery in women diagnosed with and treated with medication to stop preterm labor.

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Reports of Suspected Progesterone Side Effects

Foetal Exposure During Pregnancy (14),  Premature Baby (10),  Maternal Exposure During Pregnancy (9),  Death Neonatal (8),  Drug Ineffective (7),  Jaundice (6),  LOW Birth Weight Baby (6),  Nausea (6),  Headache (5),  Abdominal Pain Upper (5), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Progesterone review by 47 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		severe stomach pains, dizziness
Dosage & duration:		50 mg taken once a day for the period of 3 months and still one it
Other conditions:		mood swings
Other drugs taken:		none
		Reported Results
Benefits:		I have had stomach troubles my entire life. When I was pregnant they were unbearable. I could never take the pill because of nausea. I noticed that when I was 45 the nausea was associated with my cycle, becoming most intense just prior to my period. My gastroenterologist prescribed Nexium, which I took for a year, maximum dosage, daily and then tapered off. Then the other symptoms above emerged. When I started with the progesterone all these symptoms subsided significantly and I rarely ever have stomach problems now.
Side effects:		None at all that I am aware of.
Comments:		Prior to taking the oral treatment I used the cream, to avoid the digestive tract altogether. This was fine for about a year, but then the symptoms reappeared. My physician felt that something was interfering with the absorption of the hormones and so prescribed the oral pill and the symptoms have nearly disappeared and I have had no associated stomach problems. I am convinced that much of my stomach problems throughout my life were associated with a hormonal imbalance, but cannot prove this. I do know that this is the best my stomach has ever been in my entire life, for whatever reason.