DESCRIPTION
Proctofoam®-HC (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam for anal use containing hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a hydrophilic base containing cetyl alcohol, emulsifying wax, methylparaben, polyoxyethylene-10 stearyl ether, propylene glycol, propylparaben, purified water, trolamine, and inert propellants: isobutane and propane.
Proctofoam®-HC contains a synthetic corticosteroid used as an anti-inflammatory/antipruritic agent and a local anesthetic.
Hydrocortisone acetate
Molecular weight: 404.50. Solubility of hydrocortisone acetate in water: 1 mg/100 mL.
Chemical name: pregn-4-ene-3,20-dione, 21-(acetyloxy)-11, 17-dihydroxy-,(11(beta))-.
Pramoxine hydrochloride
Molecular weight: 329.86. Pramoxine hydrochloride is freely soluble in water.
Chemical name: morpholine, 4-[3-(4-butoxyphenoxy) propyl]-, hydrochloride.
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