Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic acid.
Probenecid and Colchicine (Probenecid/Colchicine) is indicated for the following:
For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.
Media Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)
Can Tomatoes Trigger Gout? (CME/CE)
Source: MedPage Today Rheumatology [2015.08.27]
(MedPage Today) -- Some support for patient claims seen in new study
New research backs belief that tomatoes can be a gout trigger
Source: Gout News From Medical News Today [2015.08.20]
People who maintain that eating tomatoes can cause their gout to flare up are likely to welcome new research from New Zealand's University of Otago that has, for the first time, found a biological...
Gout Quiz: Test Your Medical IQ
Source: MedicineNet Arthritis Specialty [2015.08.12]
Title: Gout Quiz: Test Your Medical IQ
Category: MedicineNet Quiz
Created: 1/26/2011 6:55:00 PM
Last Editorial Review: 8/12/2015 6:25:36 PM
Gout medications might be useful in treating alcohol-induced liver disease
Source: Gout News From Medical News Today [2015.08.03]
New research published in the Journal of Leukocyte Biology suggests that the combination of alcohol-induced sterile and bacterial danger signals act together in induction of liver inflammationNew...
Drug regulations tied to fewer prescriptions of effective gout drug
Source: Gout News From Medical News Today [2015.04.10]
Well intentioned, but costly and potentially problematic. That's how researchers describe the end result of a decision by the Food and Drug Administration (FDA) to regulate colchicine, a drug used...
Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)
Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis [Completed]
The purpose of this study is to determine whether oral cephalexin is equivalent to
intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft
tissue infections in patients that present to the emergency department.
A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers [Completed]
The purpose of this study is to assess the effects of multiple doses of probenecid on the
multiple-dose pharmacokinetics of canagliflozin and its metabolites in healthy volunteers.
Safety and tolerability will also be assessed.
Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure [Recruiting]
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been
used safely in humans for decades for this and other indications. The investigators have
recently discovered that this drug can also stimulate other receptors in the heart and
therefore improve its function. The hypothesis of this study is that probenecid can be used
to improve the function of the heart and therefore the symptoms in patients with heart
Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid [Completed]
Effect of Probenecid on Synovial Fluid ATP Levels in CPPD [Recruiting]
This study will investigate the hypothesis that probenecid, a medication currently used for
gout, reduces levels of ATP in the joint fluid of patients with calcium pyrophosphate
deposition disease (CPPD), another common type of crystal-related arthritis. There is
good evidence that CPPD results from an excess of ATP in joints. We will measure levels of
ATP in joint fluid before and after 5 days of treatment with probenecid. This study will
serve to rationalize larger studies of probenecid in CPPD.