Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic acid.
Probenecid and Colchicine (Probenecid/Colchicine) is indicated for the following:
For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.
Media Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)
Treat-to-Target: A New Approach to Gout? (CME/CE)
Source: MedPage Today Rheumatology [2016.10.19]
(MedPage Today) -- Dosage adjustment is crucial in effective management
Bariatric Surgery Helps Forestall Gout (CME/CE)
Source: MedPage Today Rheumatology [2016.10.12]
(MedPage Today) -- Risk of gout decreased by 34% over more than 2 decades
Gout flare-ups could be managed by blood pressure diet
Source: Arthritis / Rheumatology News From Medical News Today [2016.08.15]
Gout is both painful and common, yet the mechanisms behind it are not known. A new analysis of old data shows that easy dietary changes may keep it at bay.
Gout Attack Symptoms, Causes, Treatment, and Diet
Source: MedicineNet Elbow Pain Specialty [2016.07.15]
Title: Gout Attack Symptoms, Causes, Treatment, and Diet
Created: 6/6/2008 12:00:00 AM
Last Editorial Review: 7/15/2016 12:00:00 AM
Gout (Gouty Arthritis)
Source: MedicineNet Bunions Specialty [2016.06.06]
Title: Gout (Gouty Arthritis)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 6/6/2016 12:00:00 AM
Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)
Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis [Completed]
The purpose of this study is to determine whether oral cephalexin is equivalent to
intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft
tissue infections in patients that present to the emergency department.
A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers [Completed]
The purpose of this study is to assess the effects of multiple doses of probenecid on the
multiple-dose pharmacokinetics of canagliflozin and its metabolites in healthy volunteers.
Safety and tolerability will also be assessed.
Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure [Recruiting]
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been
used safely in humans for decades for this and other indications. The investigators have
recently discovered that this drug can also stimulate other receptors in the heart and
therefore improve its function. The hypothesis of this study is that probenecid can be used
to improve the function of the heart and therefore the symptoms in patients with heart
Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid [Completed]
Effect of Probenecid on Synovial Fluid ATP Levels in CPPD [Recruiting]
This study will investigate the hypothesis that probenecid, a medication currently used for
gout, reduces levels of ATP in the joint fluid of patients with calcium pyrophosphate
deposition disease (CPPD), another common type of crystal-related arthritis. There is
good evidence that CPPD results from an excess of ATP in joints. We will measure levels of
ATP in joint fluid before and after 5 days of treatment with probenecid. This study will
serve to rationalize larger studies of probenecid in CPPD.