Probenecid and Colchicine (Probenecid / Colchicine) - Summary

SUMMARY

Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic acid.

Probenecid and Colchicine (Probenecid/Colchicine) is indicated for the following:

For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.

See all Probenecid and Colchicine indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)

Gout Quiz: What is Gout? Is There a Gout Diet?
Source: MedicineNet Arthritis Specialty [2017.09.19]
Title: Gout Quiz: What is Gout? Is There a Gout Diet?
Category: MedicineNet Quiz
Created: 1/26/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:20:52 PM

Gout (Gouty Arthritis)
Source: MedicineNet Bunions Specialty [2017.07.07]
Title: Gout (Gouty Arthritis)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 7/7/2017 12:00:00 AM

Gout
Source: MedicineNet allopurinol Specialty [2017.05.30]
Title: Gout
Category: Symptoms and Signs
Created: 6/13/2014 12:00:00 AM
Last Editorial Review: 5/30/2017 12:00:00 AM

Gout Attack Symptoms, Causes, Treatment, and Diet
Source: MedicineNet Hydroxyapatite Specialty [2016.07.15]
Title: Gout Attack Symptoms, Causes, Treatment, and Diet
Category: Slideshows
Created: 6/6/2008 12:00:00 AM
Last Editorial Review: 7/15/2016 12:00:00 AM

Pseudogout
Source: MedicineNet Hydroxyapatite Specialty [2015.11.18]
Title: Pseudogout
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 11/18/2015 12:00:00 AM

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Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)

Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis [Completed]
The purpose of this study is to determine whether oral cephalexin is equivalent to intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft tissue infections in patients that present to the emergency department.

A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers [Completed]
The purpose of this study is to assess the effects of multiple doses of probenecid on the multiple-dose pharmacokinetics of canagliflozin and its metabolites in healthy volunteers. Safety and tolerability will also be assessed.

Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure [Recruiting]
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been used safely in humans for decades for this and other indications. The investigators have recently discovered that this drug can also stimulate other receptors in the heart and therefore improve its function. The hypothesis of this study is that probenecid can be used to improve the function of the heart and therefore the symptoms in patients with heart failure.

Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid [Completed]

Effect of Probenecid on Synovial Fluid ATP Levels in CPPD [Recruiting]
This study will investigate the hypothesis that probenecid, a medication currently used for gout, reduces levels of ATP in the joint fluid of patients with calcium pyrophosphate deposition disease (CPPD), another common type of crystal-related arthritis. There is good evidence that CPPD results from an excess of ATP in joints. We will measure levels of ATP in joint fluid before and after 5 days of treatment with probenecid. This study will serve to rationalize larger studies of probenecid in CPPD.

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