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Probenecid and Colchicine (Probenecid / Colchicine) - Summary



Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic acid.

Probenecid and Colchicine (Probenecid/Colchicine) is indicated for the following:

For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.

See all Probenecid and Colchicine indications & dosage >>


Media Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)

Source: MedicineNet Amyloidosis Specialty [2015.11.18]
Title: Pseudogout
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 11/18/2015 12:00:00 AM

Astrazeneca presents positive update on lesinurad renal data in gout patients
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.11.12]
AstraZeneca has announced positive subanalysis data of the Phase III lesinurad studies (CLEAR1, CLEAR2 and CRYSTAL) for the treatment of hyperuricemia associated with gout, in combination with a...

Gout risk high in patients with sleep apnea
Source: Gout News From Medical News Today [2015.10.20]
Sleep apnea may increase the risk of developing gout, a new study shows.Among 9865 patients with newly-diagnosed sleep apnea and 43,598 comparators of similar weight, investigators identified...

New classification system developed for gout
Source: Gout News From Medical News Today [2015.09.15]
A panel of experts and researchers have developed a new classification system for gout, the most common form of inflammatory arthritis.

New research backs belief that tomatoes can be a gout trigger
Source: Gout News From Medical News Today [2015.08.20]
People who maintain that eating tomatoes can cause their gout to flare up are likely to welcome new research from New Zealand's University of Otago that has, for the first time, found a biological...

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Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)

Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis [Completed]
The purpose of this study is to determine whether oral cephalexin is equivalent to intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft tissue infections in patients that present to the emergency department.

A Study to Assess the Effects of Multiple-Dose Probenecid on the Multiple-Dose Pharmacokinetics of Canagliflozin in Healthy Volunteers [Completed]
The purpose of this study is to assess the effects of multiple doses of probenecid on the multiple-dose pharmacokinetics of canagliflozin and its metabolites in healthy volunteers. Safety and tolerability will also be assessed.

Repurposing Probenecid as a Positive Inotrope for the Treatment of Heart Failure [Recruiting]
Probenecid is an FDA approved drug for the treatment gout and hyperuricemia. It has been used safely in humans for decades for this and other indications. The investigators have recently discovered that this drug can also stimulate other receptors in the heart and therefore improve its function. The hypothesis of this study is that probenecid can be used to improve the function of the heart and therefore the symptoms in patients with heart failure.

Drug-interaction Trial in Healthy Subjects With Oral Administration of Empagliflozin (BI 10773), Rifampicin and Probenecid [Completed]

Effect of Probenecid on Synovial Fluid ATP Levels in CPPD [Recruiting]
This study will investigate the hypothesis that probenecid, a medication currently used for gout, reduces levels of ATP in the joint fluid of patients with calcium pyrophosphate deposition disease (CPPD), another common type of crystal-related arthritis. There is good evidence that CPPD results from an excess of ATP in joints. We will measure levels of ATP in joint fluid before and after 5 days of treatment with probenecid. This study will serve to rationalize larger studies of probenecid in CPPD.

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Page last updated: 2015-11-18

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