SUMMARY
Probenecid and Colchicine
Tablets USP
Rx only
Probenecid and colchicine contains probenecid, which is a uricosuric agent, and colchicine, which has antigout activity, the mechanism of which is unknown. Probenecid is the generic name for 4-[(dipropylamino)sulfonyl] benzoic acid.
Probenecid and Colchicine (Probenecid/Colchicine) is indicated for the following:
For the treatment of chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout.
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NEWS HIGHLIGHTSMedia Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)
ASN: Febuxostat Works in Gout Patients with Renal Impairment (CME/CE)
Source: MedPage Today Rheumatology [2009.11.02]
SAN DIEGO (MedPage Today) -- In patients with gout and preexisting mild to moderate renal impairment, febuxostat (Uloric) is more effective and as safe as allopurinol, the gold standard gout treatment, researchers found.
ACR: Gout and Metabolic Disease Go Hand in Hand (CME/CE)
Source: MedPage Today Rheumatology [2009.10.27]
PHILADELPHIA (MedPage Today) -- Gout and hyperuricemia may represent another facet of metabolic syndrome, so closely tied are they to obesity, high cholesterol, and type 2 diabetes, suggested several studies presented here.
Low-Dose Colchicine (Colcrys) Is Rapid, Effective Treatment For Acute Gout Flares
Source: Gout News From Medical News Today [2009.10.26]
PHILADELPHIA - New data show that low-dose colchicine (ColcrysTM) rapidly controls acute gout flares. The results, which were presented at the 2009 Annual Scientific Meeting of the American College of Rheumatology, are drawn from a secondary analysis of the phase III Acute Gout Flare Receiving Colchicine Evaluation (AGREE) trial.
ACR: Pump Up the Allopurinol to Prevent Gout (CME/CE)
Source: MedPage Today Rheumatology [2009.10.23]
PHILADELPHIA (MedPage Today) -- Going beyond the recommended dosing of allopurinol (Zyloprim) to treat patients with gout may help prevent recurrence safely, researchers contended here.
For Management Of Hyperuricemia In Patients With Gout, Uloric (Febuxostat) Demonstrated Efficacy
Source: Gout News From Medical News Today [2009.10.21]
Additional analysis showed that reduction and long-term maintenance of normal serum urate levels also reduced risk of future gout flares Data presented at the 73rd Annual Scientific Meeting of the American College of Rheumatology highlight effects of baseline characteristics on achievement of serum uric acid (sUA) levels to
Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)
Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks [Completed]
To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated
quickly from the body, it must be taken frequently. A previous study showed that probenecid
slowed the elimination of AZT without side effects, but that study lasted only 5 days. This
study is to see whether this effect continues for 1 month and whether the continuation of
probenecid and AZT is free of side effects over 1 month.
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine [Completed]
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and
eliminated through the kidneys in HIV infected patients. Part II studies the effect of
probenecid and quinine on the same aspects.
Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep
adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT
leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT
needed for treatment.
10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors [Completed]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Probenecid may increase the effectiveness of
10-propargyl-10-deazaaminopterin by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of combining
10-propargyl-10-deazaaminopterin and probenecid in treating patients who have advanced solid
tumors.
Evaluation of Alternative Oseltamivir (Tamiflu) Dosing Strategies. [Completed]
Objective 1: Determine the safety and toxicity profile of Tamiflu administered in
combination with probenecid in healthy adults. Objective 2: Determine the pharmacokinetic
profile of Tamiflu and probenecid in healthy adults.
A Drug Interaction Study of VI-0521 With Metformin, Sitagliptan and Probenecid in Healthy Subjects. [Recruiting]
The purposes of this study are to:
- Find out how much of the study drugs are in the blood of healthy subjects after taking
multiple doses of VI-0521, metformin and sitagliptan.
- Determine the effect of probenecid on the amount of VI-0521 in the blood of healthy
subjects after taking multiple doses.
- Find out how much topiramate is in the semen of healthy male subjects after taking
multiple doses.
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