NEWS HIGHLIGHTSMedia Articles Related to Probenecid and Colchicine (Probenecid / Colchicine)
In Gout Flare-Ups, The Big Toe Isn't The Biggest Culprit - Other Joints Tied To Higher Risk
Source: Arthritis / Rheumatology News From Medical News Today [2013.06.13]
The painful rheumatic condition gout is often associated with the big toe, but it turns out that patients at highest risk of further flare-ups are those whose gout first involved other joints, such as a knee or elbow, Mayo Clinic has found. The study is among several that Mayo researchers are presenting in Madrid at the European League Against Rheumatism's annual meeting...
Will New Gout Findings Get a Toehold?
Source: MedicineNet Arthritis Specialty [2013.06.12]
Title: Will New Gout Findings Get a Toehold?
Category: Health News
Created: 6/12/2013 10:35:00 AM
Last Editorial Review: 6/12/2013 12:00:00 AM
Vitamin C Does Not Lower Uric Acid Levels In Gout Patients
Source: Gout News From Medical News Today [2013.05.16]
Despite previous studies touting its benefit in moderating gout risk, new research reveals that vitamin C, also known ascorbic acid, does not reduce uric acid (urate) levels to a clinically significant degree in patients with established gout...
UL Medical School Researchers Find Increased Death Risk In Patients Suffering From Gout And Elevated Uric Acid Levels
Source: Gout News From Medical News Today [2013.05.02]
A new study led by researchers at the Graduate Entry Medical School (GEMS), University of Limerick (UL) has found that people suffering from gout and elevated serum uric acid have significantly increased risks of death. In their study, individuals with a diagnosis of gout experienced a 42 % higher risk of death from all causes and a 58% higher risk of cardiovascular death...
Shedding Light On Gout: Repair Of Protein Pump Possible
Source: Gout News From Medical News Today [2013.04.10]
Johns Hopkins scientists have found out how a gout-linked genetic mutation contributes to the disease: by causing a breakdown in a cellular pump that clears an acidic waste product from the bloodstream. By comparing this protein pump to a related protein involved in cystic fibrosis, the researchers also identified a compound that partially repairs the pump in laboratory tests...
Clinical Trials Related to Probenecid and Colchicine (Probenecid / Colchicine)
Safety and Tolerance of Zidovudine With Probenecid and the Effect of Probenecid on Zidovudine Pharmacokinetics Over Four Weeks [Completed]
To evaluate the interaction of probenecid with zidovudine (AZT). Because AZT is eliminated
quickly from the body, it must be taken frequently. A previous study showed that probenecid
slowed the elimination of AZT without side effects, but that study lasted only 5 days. This
study is to see whether this effect continues for 1 month and whether the continuation of
probenecid and AZT is free of side effects over 1 month.
Comparison of Intravenous Cefazolin Plus Oral Probenecid With Oral Cephalexin for the Treatment of Cellulitis [Recruiting]
The purpose of this study is to determine whether oral cephalexin is equivalent to
intravenous cefazolin plus oral probenecid for the treatment of uncomplicated skin and soft
tissue infections in patients that present to the emergency department.
Influence of Probenecid and Quinine on the Pharmacokinetics of Azidothymidine [Completed]
Part I studies the effect of quinine on how zidovudine (AZT) is used by the body and
eliminated through the kidneys in HIV infected patients. Part II studies the effect of
probenecid and quinine on the same aspects.
Because AZT leaves the bloodstream quickly, patients must take the drug frequently to keep
adequate amounts in their bodies. Probenecid and quinine may slow down the rate at which AZT
leaves the body. Therefore, taking these drugs along with AZT may reduce the amount of AZT
needed for treatment.
10-Propargyl-10-Deazaaminopterin Plus Probenecid in Treating Patients With Advanced Solid Tumors [Completed]
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Probenecid may increase the effectiveness of
10-propargyl-10-deazaaminopterin by making tumor cells more sensitive to the drug.
PURPOSE: Phase I trial to study the effectiveness of combining
10-propargyl-10-deazaaminopterin and probenecid in treating patients who have advanced solid
tumors.
Evaluating the Transporter Protein Inhibitor Probenecid In Patients With Epilepsy [Recruiting]
The study is being done to understand why some patients with epilepsy (disease of recurrence
of seizures) do not respond very well to drug treatment with anticonvulsants.
Despite the availability of many anticonvulsants, about 30% of patients with epilepsy are
resistant to them. The cause of the resistance is not clear, but one of the reasons could be
an increased amount of proteins in the cells of the body called transporter proteins.
Transporter proteins are a group of proteins that help to defend the body against toxins,
including drugs, by pumping them out of the cells. Studies have shown that the number of
transporter proteins is higher in the parts of the brain that trigger seizures when compared
to other parts of the brain.
Studies in animals have shown that taking an anticonvulsant with an inhibitor (meaning "to
stop" or "to reduce") of a transporter protein can increase the concentration of that
anticonvulsant inside the brain cells. The main purpose of the study is to determine if
taking an anticonvulsant and a transporter protein inhibitor will change the brain
concentration of the anticonvulsant.
In this study, a single dose of phenytoin (Dilantin® is a brand name anticonvulsant which
has phenytoin as its active ingredient), a commonly used anticonvulsant, will be given once
by itself, and then will be given a separate time with a single (i. e. one time only) dose of
probenecid. Probenecid, a medicine used commonly to treat gout (a disease of increased uric
acid), is known to be an inhibitor of transporter proteins. The study will use
electroencephalogram or EEG (recording of brain wave activities) to determine if the EEG
pattern when probenecid is given, will be different from the EEG pattern when phenytoin is
given alone. This will suggest that probenecid has affected the brain concentration of
phenytoin.
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