The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency:
Cardiovascular: Hypotension, tachycardia, cardiac arrhythmias, hypertension, pulmonary hemorrhage.
Digestive and Hepatic: Gastrointestinal hemorrhage, nausea, vomiting, diarrhea, hepatitis.
Skin: Flushing, increased pilomotor activity with tingling or chilliness, rash.
Hematologic: Thrombocytopenia, leukopenia.
Renal: Edema, oliguria, hematuria.