Oral LD50’s (mg/kg): mice, 400; rats, 1200.
Signs and Symptoms
Signs and symptoms of overdosage may include increased pilomotor activity, peripheral vasodilatation, skin flushing, and, in rare instances, hypotension and shock.
In treating hypotension, it is most important to place the patient’s head low and administer intravenous fluids. Epinephrine should not be used, since large doses of Priscoline may cause “epinephrine reversal” (further reduction in blood pressure, followed by an exaggerated rebound).