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Priscoline (Tolazoline Hydrochloride) - Indications and Dosage



Priscoline is indicated for the treatment of persistent pulmonary hypertension of the newborn (“persistent fetal circulation”) when systemic arterial oxygenation cannot be satisfactorily maintained by usual supportive care (supplemental oxygen and/or mechanical ventilation).

Priscoline should be used in a highly supervised setting, where vital signs, oxygenation, acid-base status, fluid, and electrolytes can be monitored and maintained.


An initial dose of 1 to 2 mg/kg, via scalp vein, followed by an infusion of 1 to 2 mg/kg per hour have usually resulted in significant increases in arterial oxygen. There is very little experience with infusions lasting beyond 36 to 48 hours. Response, if it occurs, can be expected within 30 minutes after the initial dose.

Note: Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.


Ampuls 4 mL— each milliliter contains 25 mg of tolazoline hydrochloride.

Carton of 4 ampuls……………………………………………………….NDC 0083-6733-04

Store between 15ºC and 30ºC (59ºF-86ºF).

Protect from light.

665480                                C98-24 (Rev. 9/98)

Distributed by

Novartis Pharmaceuticals Corporation

East Hanover, New Jersey 07936

©1998 Novartis

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