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Prevacid (Lansoprazole) - Summary

 
 



PREVACID SUMMARY

The active ingredient in PREVACID (lansoprazole) Delayed-Release Capsules, PREVACID (lansoprazole) for Delayed-Release Oral Suspension and PREVACID SoluTab (lansoprazole) Delayed-Release Orally Disintegrating Tablets is a substituted benzimidazole, 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl] sulfinyl] benzimidazole, a compound that inhibits gastric acid secretion.

PREVACID Delayed-Release Capsules, PREVACID SoluTab Delayed-Release Orally Disintegrating Tablets and PREVACID For Delayed-Release Oral Suspension are indicated for:

SHORT-TERM TREATMENT OF ACTIVE DUODENAL ULCER

PREVACID is indicated for short-term treatment (for 4 weeks) for healing and symptom relief of active duodenal ulcer.

H. PYLORI ERADICATION TO REDUCE THE RISK OF DUODENAL ULCER RECURRENCE

Triple Therapy: PREVACID/amoxicillin/clarithromycin

PREVACID in combination with amoxicillin plus clarithromycin as triple therapy is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. (See CLINICAL STUDIES and DOSAGE AND ADMINISTRATION.)

Dual Therapy: PREVACID/amoxicillin

PREVACID in combination with amoxicillin as dual therapy is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or one-year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. (See the clarithromycin package insert, MICROBIOLOGY section.) Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence. (See CLINICAL STUDIES and DOSAGE AND ADMINISTRATION.)

MAINTENANCE OF HEALED DUODENAL ULCERS

PREVACID is indicated to maintain healing of duodenal ulcers. Controlled studies do not extend beyond 12 months.

SHORT-TERM TREATMENT OF ACTIVE BENIGN GASTRIC ULCER

PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of active benign gastric ulcer.

HEALING OF NSAID-ASSOCIATED GASTRIC ULCER

PREVACID is indicated for the treatment of NSAID-associated gastric ulcer in patients who continue NSAID use. Controlled studies did not extend beyond 8 weeks.

RISK REDUCTION OF NSAID-ASSOCIATED GASTRIC ULCER

PREVACID is indicated for reducing the risk of NSAID-associated gastric ulcers in patients with a history of a documented gastric ulcer who require the use of an NSAID. Controlled studies did not extend beyond 12 weeks.

GASTROESOPHAGEAL REFLUX DISEASE (GERD)

Short-Term Treatment of Symptomatic GERD

PREVACID is indicated for the treatment of heartburn and other symptoms associated with GERD.

Short-Term Treatment of Erosive Esophagitis

PREVACID is indicated for short-term treatment (up to 8 weeks) for healing and symptom relief of all grades of erosive esophagitis.

For patients who do not heal with PREVACID for 8 weeks (5-10%), it may be helpful to give an additional 8 weeks of treatment.

If there is a recurrence of erosive esophagitis an additional 8-week course of PREVACID may be considered.

MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS

PREVACID is indicated to maintain healing of erosive esophagitis. Controlled studies did not extend beyond 12 months.

PATHOLOGICAL HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME

PREVACID is indicated for the long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome.


See all Prevacid indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Prevacid (Lansoprazole)

Distinguishing the impact of dexlansoprazole on heartburn vs. regurgitation in patients with gastro-oesophageal reflux disease. [2013]
(EE)... CONCLUSIONS: Dexlansoprazole appears to be effective in improving both heartburn

A multicenter, randomized, comparative study to determine the appropriate dose of lansoprazole for use in the diagnostic test for gastroesophageal reflux disease. [2011.09]
BACKGROUND/AIMS: The diagnostic proton pump inhibitor test (PPI test) is a method used in diagnosing gastroesophageal reflux disease (GERD). This study aimed to determine the appropriate dose of lansoprazole for use in the diagnostic test for GERD... CONCLUSIONS: In this multicenter, randomized study of Korean patients, the standard dose of lansoprazole was as effective as a high dose of lansoprazole in relieving the symptoms of GERD, regardless of the presence of ERD, by day 14 of treatment.

Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers. [2011.07]
The preventive effects of lansoprazole and famotidine on low-dose aspirin-induced gastric mucosal injury in relation to gastric acidity were compared in healthy Japanese volunteers. Fifteen Helicobacter pylori-negative volunteers with different CYP2C19 genotypes were randomly administered aspirin 100 mg, aspirin plus famotidine 20 mg twice daily, or aspirin plus lansoprazole 15 mg once daily for 7 days each in a crossover fashion.

Lansoprazole for secondary prevention of gastric or duodenal ulcers associated with long-term low-dose aspirin therapy: results of a prospective, multicenter, double-blind, randomized, double-dummy, active-controlled trial. [2011.06]
BACKGROUND: The efficacy of low-dose lansoprazole has not been established for the prevention of recurrent gastric or duodenal ulcers in those receiving long-term low-dose aspirin (LDA) for cardiovascular and cerebrovascular protection. This study sought to examine the efficacy of low-dose lansoprazole (15 mg once daily) for the secondary prevention of LDA-associated gastric or duodenal ulcers... CONCLUSION: Lansoprazole was superior to gefarnate in reducing the risk of gastric or duodenal ulcer recurrence in patients with a definite history of gastric or duodenal ulcers who required long-term LDA therapy.

The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD. [2011.03]
OBJECTIVES: Nocturnal heartburn and related sleep disturbances are common among patients with gastroesophageal reflux disease (GERD). This study evaluated the efficacy of dexlansoprazole MR 30 mg in relieving nocturnal heartburn and GERD-related sleep disturbances, improving work productivity, and decreasing nocturnal symptom severity in patients with symptomatic GERD... CONCLUSIONS: In patients with symptomatic GERD, dexlansoprazole MR 30 mg is significantly more efficacious than placebo in providing relief from nocturnal heartburn, in reducing GERD-related sleep disturbances and the consequent impairments in work productivity, and in improving sleep quality/quality of life.

more studies >>

Clinical Trials Related to Prevacid (Lansoprazole)

Intravenous vs Oral Lansoprazole on Gastric Acid Secretion in Subjects With Erosive Esophagitis [Completed]
The objective of this study was to compare the pharmacodynamics of intravenous (IV) lansoprazole 30 mg to oral lansoprazole 30 mg capsules in subjects with erosive esophagitis.

Study Comparing Esomeprazole Magnesium 40mg Once Daily Versus Lansoprazole 30 mg Twice Daily in Symptom Control of Subjects With Persistent GERD [Completed]
A double-blind study comparing Esomeprazole Magnesium 40 mg once daily and Lansoprazole 30 mg twice daily to control the symptoms in patients with gastroesophageal reflux disease (GERD) with continued heartburn symptoms with a course of therapy of 30 mg twice daily Lansoprazole.

Efficacy/Safety of Lansoprazole in Patients With Frequent Nighttime Heartburn [Completed]
Heartburn, a burning sensation in the chest or throat, occurs in many individuals when acidic stomach contents move upward into the esophagus from the stomach. This study will investigate the safety and efficacy of lansoprazole 15 mg or 30 mg administered once a day in preventing frequent nighttime heartburn.

Efficacy of TAK-438 Compared to AG-1749 (Lansoprazole) in the Treatment of Erosive Esophagitis [Not yet recruiting]
The purpose of this study is to determine the efficacy of TAK-438, once daily (QD), compared to lansoprazole in patients with erosive esophagitis of Grade A to D as defined by the LA classification grading system.

Effect of Prevacid on Prostaglandin Levels in Patient With Stress Ulcer [Recruiting]
The purpose of this study is to measure the prostaglandin levels in patients with stress ulcer and the effect of Prevacid on prostaglandin levels in patients with stress ulcer.

more trials >>

Reports of Suspected Prevacid (Lansoprazole) Side Effects

Drug Ineffective (29)Drug Dose Omission (23)Malaise (20)Gastrooesophageal Reflux Disease (16)Dyspepsia (13)Diarrhoea (12)Vomiting (11)Weight Decreased (9)Fatigue (9)Chest Pain (9)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 22 ratings/reviews, Prevacid has an overall score of 7.77. The effectiveness score is 8 and the side effect score is 8.64. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Prevacid review by 54 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   acid reflux
Dosage & duration:   30 mg taken once daily for the period of 1 month
Other conditions:   asthma
Other drugs taken:   Advair
  
Reported Results
Benefits:   Taken each morning 30 minutes before eating, keep me from having any acid reflux. One daily dosage worked for the entire day. Even into the evening, if I ate spicy food or chocolate, I could go to bed without experiencing any heart burn.
Side effects:   None that I have encountered.
Comments:   I have been taking meds for my acid reflux for many years, originally Omeprazole (generic for Prilosec). However, becaus Omeprazole was not on my insurance drug formulary, I was taking Prilosec OTC. At my last check-up my doctor prescribed the Prevacid and I like it. It even tastes like strawberries!

 

Prevacid review by 57 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   pre-barrett (errosion of the esophagus)
Dosage & duration:   30 Mg. once a day taken once for the period of still taking it
Other conditions:   GIRD
Other drugs taken:   none
  
Reported Results
Benefits:   the prevacid allows me to eat and drink certain foods/fluids that I normally could not tolerate anymore without great discomfort i.e. spicy foods, coffee, chocolate, tomato products, and alcholic drinks, which I only drink occassionally such as red wine. If I skip the prevacid for any reason, I almost certainly will be very uncomfortable.
Side effects:   It seems to give me a tendency to gain weight in the abdomen. I did try some alternatives, including Nexium, which was not a good substitute at all!
Comments:   I have been on prevacid for approximately 6 years as a a prophylactic against the pre-barretts. I have tried to slowly come off the drug (it is the only one I use) but I would venture to guess that unless I changed my diet significantly, this is not going to happen.

 

Prevacid review by 82 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Indigestion
Dosage & duration:   one per day (dosage frequency: two days) for the period of Once for two days
Other conditions:   Nothing just indigestion through the night
Other drugs taken:   gaviscon
  
Reported Results
Benefits:   This was recommended to me instead of Gaviscon. Supposedly it was a better solution for my indigestion. Instead it was a disaster.
Side effects:   Terrible Terrible. I already suffer from constipation, but I took one of these tablets, as prescribed, for two consecutive days. After two days I knew they were a no-no for me. My innards came to a complete STOP. I shall throw the remainder of the tablets away. Four days on my innards are still at a standstill.
Comments:   Take one per day. I have stopped taking them. Don't forget I already take Dulcolax for my constipation, had I known these recommended tablets had a side effect of constipation I would have refused them. It is back to the Gaviscon for me, it is gentle, pleasant to take and liquid. Shell-like Capsules and me do not get along.

See all Prevacid reviews / ratings >>

Page last updated: 2014-11-30

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