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Prednisone (Prednisone) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

(listed alphabetically, under each subsection)

The following adverse reactions have been reported with prednisone or other corticosteroids:

Allergic Reactions

anaphylactoid or hypersensitivity reactions, anaphylaxis, angioedema.

Cardiovascular System

bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, ECG changes caused by potassium deficiency, edema, fat embolism, hypertension or aggravation of hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see:), necrotizing angiitis, pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis. WARNINGS Cardio-Renal

Dermatologic

acne, acneiform eruptions, allergic dermatitis, alopecia, angioedema, angioneurotic edema, atrophy and thinning of skin, dry scaly skin, ecchymoses and petechiae (bruising), erythema, facial edema, hirsutism, impaired wound healing, increased sweating, Karposiā€™s sarcoma (see:), lupus erythematosus-like lesions, perineal irritation, purpura, rash, striae, subcutaneous fat atrophy, suppression of reactions to skin tests, striae, telangiectasis, thin fragile skin, thinning scalp hair, urticaria. PRECAUTIONS General Precautions

Endocrine

Adrenal insufficiency-greatest potential caused by high potency glucocorticoids with long duration of action (associated symptoms include; arthralgias, buffalo hump, dizziness, life-threatening hypotension, nausea, severe tiredness or weakness), amenorrhea, postmenopausal bleeding or other menstrual irregularities, decreased carbohydrate and glucose tolerance, development of cushingoid state, diabetes mellitus (new onset or manifestations of latent), glycosuria, hyperglycemia, hypertrichosis, hyperthyroidism (see:), hypothyroidism, increased requirements for insulin or oral hypoglycemic agents in diabetics, lipids abnormal, moon face, negative nitrogen balance caused by protein catabolism, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery or illness) (see:), suppression of growth in pediatric patients. WARNINGS Endocrine WARNINGS Endocrine

Fluid and Electrolyte Disturbances

congestive heart failure in susceptible patients, fluid retention, hypokalemia, hypokalemic alkalosis, metabolic alkalosis, hypotension or shock-like reaction, potassium loss, sodium retention with resulting edema.

Gastrointestinal

abdominal distention, abdominal pain,anorexia which may result in weight loss, constipation, diarrhea, elevation in serum liver enzyme levels (usually reversible upon discontinuation), gastric irritation, hepatomegaly, increased appetite and weight gain, nausea, oropharyngeal candidiasis, pancreatitis, peptic ulcer with possible perforation and hemorrhage, perforation of the small and large intestine (particularly in patients with inflammatory bowel disease), ulcerative esophagitis, vomiting.

Hematologic

anemia, neutropenia (including febrile neutropenia).

Metabolic

negative nitrogen balance due to protein catabolism.

Musculoskeletal

arthralgias, aseptic necrosis of femoral and humeral heads, increase risk of fracture, loss of muscle mass, muscle weakness, myalgias, osteopenia, osteoporosis (see:), pathologic fracture of long bones, steroid myopathy, tendon rupture (particularly of the Achilles tendon), vertebral compression fractures. PRECAUTIONS Musculoskeletal

Neurological/Psychiatric

amnesia, anxiety, benign intracranial hypertension, convulsions, delirium, dementia (characterized by deficits in memory retention, attention, concentration, mental speed and efficiency, and occupational performance), depression, dizziness, EEG abnormalities, emotional instability and irritability, euphoria, hallucinations, headache, impaired cognition, incidence of severe psychiatric symptoms, increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment, increased motor activity, insomnia, ischemic neuropathy, long-term memory loss, mania, mood swings, neuritis, neuropathy, paresthesia, personality changes, psychiatric disorders including steroid psychoses or aggravation of pre-existing psychiatric conditions, restlessness, schizophrenia, verbal memory loss, vertigo, withdrawn behavior.

Ophthalmic

blurred vision, cataracts (including posterior subcapsular cataracts), central serous chorioretinopathy, establishment of secondary bacterial, fungal and viral infections, exophthalmos, glaucoma, increased intraocular pressure (see:), optic nerve damage, papilledema. PRECAUTIONS Ophthalmic

Other

abnormal fat deposits, aggravation/masking of infections, decreased resistance to infection (see:), hiccups, immunosuppresion, increased or decreased motility and number of spermatozoa, malaise, insomnia, moon face, pyrexia. WARNINGS Infection



REPORTS OF SUSPECTED PREDNISONE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Prednisone. The information is not vetted and should not be considered as verified clinical evidence.

Possible Prednisone side effects / adverse reactions in 82 year old female

Reported by a health professional (non-physician/pharmacist) from Turkey on 2011-10-03

Patient: 82 year old female

Reactions: Febrile Neutropenia

Adverse event resulted in: death

Suspect drug(s):
Cyclophosphamide
    Dosage: cycle 2

Rituximab

Doxorubicin Hydrochloride
    Dosage: cycle 1

Vincristine
    Indication: non-Hodgkin's Lymphoma

Rituximab
    Indication: non-Hodgkin's Lymphoma

Prednisone
    Dosage: cycle 2
    Indication: non-Hodgkin's Lymphoma

Doxorubicin Hydrochloride
    Dosage: cycle 1

Doxorubicin Hydrochloride
    Dosage: cycle 2

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Dosage: cycle 2

Prednisone

Doxorubicin Hydrochloride
    Dosage: cycle 2

Doxorubicin Hydrochloride
    Dosage: cycle 2

Doxorubicin Hydrochloride
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma



Possible Prednisone side effects / adverse reactions in 80 year old male

Reported by a physician from Italy on 2011-10-03

Patient: 80 year old male

Reactions: Transient Ischaemic Attack

Adverse event resulted in: hospitalization

Suspect drug(s):
Prednisone
    Administration route: Oral
    Indication: Prostate Cancer
    Start date: 2011-06-01
    End date: 2011-06-01

Docetaxel
    Indication: Prostate Cancer
    Start date: 2011-06-01
    End date: 2011-06-01

Lenalidomide
    Administration route: Oral
    Indication: Prostate Cancer
    Start date: 2011-06-01
    End date: 2011-06-14

Prednisone
    Administration route: Oral
    Start date: 2011-08-05
    End date: 2011-08-24

Lenalidomide
    Administration route: Oral
    Start date: 2011-08-05
    End date: 2011-08-18

Docetaxel
    Start date: 2011-08-05
    End date: 2011-08-05

Other drugs received by patient: Lansoprazole; Phenobarbital TAB; Filgrastim; Furosemide; Ticlopidine HCL



Possible Prednisone side effects / adverse reactions in 86 year old male

Reported by a physician from Taiwan, Province of China on 2011-10-04

Patient: 86 year old male weighing 65.8 kg (144.8 pounds)

Reactions: Pyrexia

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Prednisone
    Administration route: Oral
    Indication: Prostate Cancer Metastatic

Cabazitaxel
    Indication: Prostate Cancer Metastatic
    Start date: 2011-07-25
    End date: 2011-07-25

Cabazitaxel
    Start date: 2011-09-19
    End date: 2011-09-19



See index of all Prednisone side effect reports >>

Drug label data at the top of this Page last updated: 2012-11-13

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