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Prednisone (Prednisone) - Description and Clinical Pharmacology

 
 



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DESCRIPTION

Each tablet for oral administration contains:

Prednisone.............................................................1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, and 50 mg

Each 5 mL of oral solution for oral administration contains:

Prednisone............................................................................................................................... 5 mg

Alcohol.................................................................................................................................... 5%

Each mL of ™ for oral administration contains: Intensol

Prednisone............................................................................................................................... 5 mg

Alcohol.................................................................................................................................... 30%

Inactive Ingredients

The tablets contain lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch and sodium starch glycolate. In addition, the 1 mg, 2.5 mg, and 5 mg tablets also contain stearic acid.

Prednisone Oral Solution contains alcohol, citric acid, disodium edetate, fructose, hydrochloric acid, maltol, peppermint oil, polysorbate 80, propylene glycol, saccharin sodium, sodium benzoate, vanilla flavor and water.

Prednisone Intensol contains alcohol, citric acid, poloxamer 188, propylene glycol and water.

Prednisone tablets contain prednisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. The chemical name for prednisone is pregna-1,4-diene-3,11,20-trione monohydrate,17,21-dihydroxy-. The structural formula is represented below:

C H O M.W. 358.43 21 26 5

Prednisone is a white to practically white, odorless, crystalline powder. It is very slightly soluble in water; slightly soluble in alcohol, chloroform, dioxane, and methanol.

CLINICAL PHARMACOLOGY

Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems.

Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body’s immune responses to diverse stimuli.

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