Prednisone is a glucocorticoid.
Prednisone tablets and solutions are indicated in the following conditions:
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice: synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis.
As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis, rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis.
During an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, systemic dermatomyositis (polymyositis), acute rheumatic carditis.
Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; mycosis fungoides; severe psoriasis; severe seborrheic dermatitis.
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions.
Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis.
Symptomatic sarcoidosis; LoefflerÂ’s syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; aspiration pneumonitis.
Idiopathic thrombocytopenic purpura in adults; secondary thrombocytopenia in adults; acquired (autoimmune) hemolytic anemia; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia.
For palliative management of: leukemias and lymphomas in adults, acute leukemia of childhood.
To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.
To tide the patient over a critical period of the disease in: ulcerative colitis, regional enteritis.
Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement.
Media Articles Related to Prednisone
Data Lacking on Prednisone Use in RA (CME/CE)
Source: MedPage Today Rheumatology [2017.01.05]
(MedPage Today) -- Glucocorticoid treatment may be the best and worst possible option
Custirsen shows no survival benefits in metastatic prostate cancer
Source: Prostate / Prostate Cancer News From Medical News Today [2016.10.12]
A phase III randomized controlled trial of custirsen in combination with cabazitaxel/prednisone in patients with previously-treated metastatic, castration-resistant prostate cancer has shown no...
Dexamethasone for asthma in the ER: Better compliance, nearly equal effectiveness
Source: Compliance News From Medical News Today [2016.04.28]
Adults with asthma who were treated with one-dose dexamethasone in the emergency department had only slightly higher relapse than patients who were treated with a 5-day course of prednisone.
Published Studies Related to Prednisone
Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive
men with metastatic castration-resistant prostate cancer: patient-reported
outcome results of a randomised phase 3 trial. 
pain and functional status in a preplanned interim analysis of a phase 3 trial... INTERPRETATION: Abiraterone plus prednisone delays patient-reported pain
Are changes in bone mineral density different between groups of early rheumatoid
arthritis patients treated according to a tight control strategy with or without
prednisone if osteoporosis prophylaxis is applied? 
prednisone in early RA patients who received preventive therapy for osteoporosis... CONCLUSION: Addition of 10 mg prednisone daily to a methotrexate-based tight
Effect of abiraterone acetate and prednisone compared with placebo and prednisone
on pain control and skeletal-related events in patients with metastatic
castration-resistant prostate cancer: exploratory analysis of data from the
COU-AA-301 randomised trial. 
docetaxel chemotherapy... INTERPRETATION: In patients with metastatic castration-resistant prostate cancer
Randomized phase II trial of docetaxel plus prednisone in combination with
placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line
therapy for metastatic castration-resistant prostate cancer. 
AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in
Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. [2011.11.29]
BACKGROUND: AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC). A randomized, double-blind, placebo-controlled phase II trial compared DP combined with either AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in mCRPC; a potential benefit was observed in high-risk patients.
Clinical Trials Related to Prednisone
The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach [Recruiting]
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with
polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose
glucocorticoids ( 5 mg/day of prednisone) as compared to stopping glucocorticoid treatment
entirely (0 mg/day of prednisone)on rates of disease relapse/disease flares.
This study is a novel approach to conducting a randomized clinical trial in the community
setting. This study is being conducted in parallel with a similar study at established
vasculitis institutions. This study will have a patient centric approach to research in
that subjects will be recruited online and through social media and vasculitis support
networks. Participants will be consented online and will receive care through their regular
treating physician so no travel or additional doctor visits are required. Study participants
will consent to the study and complete online questionnaires about their prednisone dose and
about how they are feeling.
The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach [Recruiting]
This study is a multi-center randomized controlled trial to evaluate the effects of using
low-dose prednisone as compared to stopping prednisone treatment entirely. Participants will
be randomized 1: 1 to taper their prednisone dose down to 5 mg/day or to 0 mg/day for the
duration of the study (approximately six months) or until a study endpoint.
Dose-comparison Study of Prednisone in Heart Failure [Completed]
The purpose of this study is to examine the efficacy of three doses of prednisone, a
glucocorticoid, in treatment of patients with symptomatic heart failure.
Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant [Terminated]
The purpose of the study was to determine if rapid discontinuation of corticosteroids (also
known as prednisone withdrawal) and maintenance immunosuppression with Prograf (tacrolimus)
and CellCept (mycophenolate mofetil) while using Thymoglobulin (Rabbit antithymocyte
globulin) will give similar safety and efficacy results compared to continuation of
corticosteroids (also known as prednisone maintenance) and standard maintenance
immunosuppression with Prograf (tacrolimus), CellCept (mycophenolate mofetil) while using
Thymoglobulin (Rabbit antithymocyte globulin).
A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMR [Terminated]
Reports of Suspected Prednisone Side Effects
Febrile Neutropenia (97),
Sepsis (77), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 26 ratings/reviews, Prednisone has an overall score of 6.65. The effectiveness score is 8.69 and the side effect score is 6.69. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Prednisone review by 58 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || rheumatoid arthritis|
|Dosage & duration:|| || 5 mg taken once per day for the period of 6 months|
|Other conditions:|| || none|
|Other drugs taken:|| || Humira, methotrexate, lorazapame|
|Benefits:|| || reduced the fatigue, swelling and pain associated with RA|
|Side effects:|| || mild tendency to gain weight, however appetite which had been flagging was regained|
|Comments:|| || Take the medication in larger doses at the very beginning, and then taper off gradually. Very important to taper, no sudden stops or starts to this medication, adverse effects if you do.|
Prednisone review by 28 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || Sudden Sensorineural hearing loss|
|Dosage & duration:|| || 60mg total daily dose taken 30mg bid for 9 days and then taper down for the period of 14 days|
|Other conditions:|| || None|
|Other drugs taken:|| || Zyrtec and Birth Control|
|Benefits:|| || I regained my hearing after a virus caused sudden sensorineural hearing loss in my left ear by taking Prednisone. |
|Side effects:|| || Night waking, restlessness, increased speech, mild mania, GI abnormalities, stomach upset, nausea.|
|Comments:|| || I regained my hearing after a virus caused sudden sensorineural hearing loss in my left ear by taking Prednisone.|
Prednisone review by 59 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Moderately Effective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || allergic reaction on face to a cosmetic|
|Dosage & duration:|| || 6400 mg. tapered over 18 days taken 3 x daily for the period of 14 days|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || Facial swelling reduced dramatically over 3 days, only to return (less so) as a side effect. I could have just taken Benadryl, and although it would have taken longer to recover from the allergic reaction (possibly another week), I would have been normal without side effects, and without withdrawal effects. The drug took a modest problem and created a far worse one. I told the physician I reacted strongly to drugs. Since then I've learned that some physicians are quite blasé about the side effects of prednisone -- apparently that old adage about "first do no wrong" is no longer important.|
|Side effects:|| || constant : pulse pounding throughout body, flushed face, odd-looking eyes (dilated), high blood pressure ( systolic range 145-194; ), fatigue, severe insomnia, nervousness, inability to concentrate, mild vertigo (spill, drop, lurch, and fall).
Withdrawal symptoms (fatigue, tinnitus, leg aches) continue after 4 weeks, though improving gradually.
increasing over time : panic attacks, anxiety |
|Comments:|| || Oral, 10 mg. tablets, 3 days at 60mg, gradual tapering over 18 days|
Page last updated: 2017-01-05