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Prednisone (Prednisone) - Summary

 
 



PREDNISONE SUMMARY

Prednisone is a glucocorticoid.

Prednisone tablets and solutions are indicated in the following conditions:

Endocrine Disorders

Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice: synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis.

Rheumatic Disorders

As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis, rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy), ankylosing spondylitis, acute and subacute bursitis, acute nonspecific tenosynovitis, acute gouty arthritis, post-traumatic osteoarthritis, synovitis of osteoarthritis, epicondylitis.

Collagen Diseases

During an exacerbation or as maintenance therapy in selected cases of: systemic lupus erythematosus, systemic dermatomyositis (polymyositis), acute rheumatic carditis.

Dermatologic Diseases

Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome); exfoliative dermatitis; mycosis fungoides; severe psoriasis; severe seborrheic dermatitis.

Allergic States

Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment: seasonal or perennial allergic rhinitis; bronchial asthma; contact dermatitis; atopic dermatitis; serum sickness; drug hypersensitivity reactions.

Ophthalmic Diseases

Severe acute and chronic allergic and inflammatory processes involving the eye and its adnexa such as: allergic corneal marginal ulcers, herpes zoster ophthalmicus, anterior segment inflammation, diffuse posterior uveitis and choroiditis, sympathetic ophthalmia, allergic conjunctivitis, keratitis, chorioretinitis, optic neuritis, iritis and iridocyclitis.

Respiratory Diseases

Symptomatic sarcoidosis; LoefflerÂ’s syndrome not manageable by other means; berylliosis; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; aspiration pneumonitis.

Hematologic Disorders

Idiopathic thrombocytopenic purpura in adults; secondary thrombocytopenia in adults; acquired (autoimmune) hemolytic anemia; erythroblastopenia (RBC anemia); congenital (erythroid) hypoplastic anemia.

Neoplastic Diseases

For palliative management of: leukemias and lymphomas in adults, acute leukemia of childhood.

Edematous States

To induce a diuresis or remission of proteinuria in the nephrotic syndrome, without uremia, of the idiopathic type or that due to lupus erythematosus.

Gastrointestinal Diseases

To tide the patient over a critical period of the disease in: ulcerative colitis, regional enteritis.

Miscellaneous

Tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy; trichinosis with neurologic or myocardial involvement.


See all Prednisone indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Prednisone

Abiraterone acetate plus prednisone versus prednisone alone in chemotherapy-naive men with metastatic castration-resistant prostate cancer: patient-reported outcome results of a randomised phase 3 trial. [2013]
pain and functional status in a preplanned interim analysis of a phase 3 trial... INTERPRETATION: Abiraterone plus prednisone delays patient-reported pain

Are changes in bone mineral density different between groups of early rheumatoid arthritis patients treated according to a tight control strategy with or without prednisone if osteoporosis prophylaxis is applied? [2013]
prednisone in early RA patients who received preventive therapy for osteoporosis... CONCLUSION: Addition of 10 mg prednisone daily to a methotrexate-based tight

Effect of abiraterone acetate and prednisone compared with placebo and prednisone on pain control and skeletal-related events in patients with metastatic castration-resistant prostate cancer: exploratory analysis of data from the COU-AA-301 randomised trial. [2012]
docetaxel chemotherapy... INTERPRETATION: In patients with metastatic castration-resistant prostate cancer

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. [2012]
AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in

Randomized phase II trial of docetaxel plus prednisone in combination with placebo or AT-101, an oral small molecule Bcl-2 family antagonist, as first-line therapy for metastatic castration-resistant prostate cancer. [2011.11.29]
BACKGROUND: AT-101 (A), a small molecule oral inhibitor of the Bcl-2 family, has activity alone and in combination with docetaxel (Taxotere) and prednisone (DP) in metastatic castration-resistant prostate cancer (mCRPC). A randomized, double-blind, placebo-controlled phase II trial compared DP combined with either AT-101 (A) or placebo in chemonaive mCRPC... CONCLUSIONS: AT-101 was tolerable but did not extend OS when combined with DP in mCRPC; a potential benefit was observed in high-risk patients.

more studies >>

Clinical Trials Related to Prednisone

The Assessment of Prednisone In Remission Trial (TAPIR) - Patient Centric Approach [Recruiting]
This is a randomized controlled trial in patients with a diagnosis of granulomatosis with polyangiitis (GPA; Wegener's)that are in remission to evaluate the effects of using low-dose glucocorticoids ( 5 mg/day of prednisone) as compared to stopping glucocorticoid treatment entirely (0 mg/day of prednisone)on rates of disease relapse/disease flares. This study is a novel approach to conducting a randomized clinical trial in the community setting. This study is being conducted in parallel with a similar study at established vasculitis institutions. This study will have a patient centric approach to research in that subjects will be recruited online and through social media and vasculitis support networks. Participants will be consented online and will receive care through their regular treating physician so no travel or additional doctor visits are required. Study participants will consent to the study and complete online questionnaires about their prednisone dose and about how they are feeling.

The Assessment of Prednisone In Remission Trial - Centers of Excellence Approach [Recruiting]
This study is a multi-center randomized controlled trial to evaluate the effects of using low-dose prednisone as compared to stopping prednisone treatment entirely. Participants will be randomized 1: 1 to taper their prednisone dose down to 5 mg/day or to 0 mg/day for the duration of the study (approximately six months) or until a study endpoint.

Dose-comparison Study of Prednisone in Heart Failure [Completed]
The purpose of this study is to examine the efficacy of three doses of prednisone, a glucocorticoid, in treatment of patients with symptomatic heart failure.

Prednisone Withdrawal Versus Prednisone Maintenance After Kidney Transplant [Terminated]
The purpose of the study was to determine if rapid discontinuation of corticosteroids (also known as prednisone withdrawal) and maintenance immunosuppression with Prograf (tacrolimus) and CellCept (mycophenolate mofetil) while using Thymoglobulin (Rabbit antithymocyte globulin) will give similar safety and efficacy results compared to continuation of corticosteroids (also known as prednisone maintenance) and standard maintenance immunosuppression with Prograf (tacrolimus), CellCept (mycophenolate mofetil) while using Thymoglobulin (Rabbit antithymocyte globulin).

A Study Assessing the Efficacy and Safety of Lodotra® Compared to Prednisone IR in Subjects Suffering From PMR [Terminated]

more trials >>

Reports of Suspected Prednisone Side Effects

Pneumonia (146)Pyrexia (112)Anaemia (98)Febrile Neutropenia (97)Nausea (89)Neutropenia (89)Dyspnoea (88)Diarrhoea (88)Fatigue (86)Sepsis (77)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 26 ratings/reviews, Prednisone has an overall score of 6.65. The effectiveness score is 8.69 and the side effect score is 6.69. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Prednisone review by 58 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   rheumatoid arthritis
Dosage & duration:   5 mg taken once per day for the period of 6 months
Other conditions:   none
Other drugs taken:   Humira, methotrexate, lorazapame
  
Reported Results
Benefits:   reduced the fatigue, swelling and pain associated with RA
Side effects:   mild tendency to gain weight, however appetite which had been flagging was regained
Comments:   Take the medication in larger doses at the very beginning, and then taper off gradually. Very important to taper, no sudden stops or starts to this medication, adverse effects if you do.

 

Prednisone review by 28 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Sudden Sensorineural hearing loss
Dosage & duration:   60mg total daily dose taken 30mg bid for 9 days and then taper down for the period of 14 days
Other conditions:   None
Other drugs taken:   Zyrtec and Birth Control
  
Reported Results
Benefits:   I regained my hearing after a virus caused sudden sensorineural hearing loss in my left ear by taking Prednisone.
Side effects:   Night waking, restlessness, increased speech, mild mania, GI abnormalities, stomach upset, nausea.
Comments:   I regained my hearing after a virus caused sudden sensorineural hearing loss in my left ear by taking Prednisone.

 

Prednisone review by 59 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   allergic reaction on face to a cosmetic
Dosage & duration:   6400 mg. tapered over 18 days taken 3 x daily for the period of 14 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Facial swelling reduced dramatically over 3 days, only to return (less so) as a side effect. I could have just taken Benadryl, and although it would have taken longer to recover from the allergic reaction (possibly another week), I would have been normal without side effects, and without withdrawal effects. The drug took a modest problem and created a far worse one. I told the physician I reacted strongly to drugs. Since then I've learned that some physicians are quite blasé about the side effects of prednisone -- apparently that old adage about "first do no wrong" is no longer important.
Side effects:   constant : pulse pounding throughout body, flushed face, odd-looking eyes (dilated), high blood pressure ( systolic range 145-194; ), fatigue, severe insomnia, nervousness, inability to concentrate, mild vertigo (spill, drop, lurch, and fall). Withdrawal symptoms (fatigue, tinnitus, leg aches) continue after 4 weeks, though improving gradually. increasing over time : panic attacks, anxiety
Comments:   Oral, 10 mg. tablets, 3 days at 60mg, gradual tapering over 18 days

See all Prednisone reviews / ratings >>

Page last updated: 2014-11-30

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