Prednisolone (Prednisolone Sodium Phosphate) - Side Effects and Adverse Reactions

Cardiovascular

Hypertrophic cardiomyopathy in premature infants.

Dermatologic

Facial erythema; increased sweating; impaired wound healing; may suppress reactions to skin tests; petechiae and ecchymoses; thin fragile skin; urticaria; edema.

Endocrine

Decreased carbohydrate tolerance; development of cushingoid state; hirsutism; increased requirements for insulin or oral hypoglycemic agents in diabetic patients; manifestations of latent diabetes mellitus; menstrual irregularities; secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery or illness; suppression of growth in children.

Fluid and Electrolyte Disturbances

Congestive heart failure in susceptible patients; fluid retention; hypertension; hypokalemic alkalosis; potassium loss; sodium retention.

Gastrointestinal

Abdominal distention; elevation in serum liver enzyme levels (usually reversible upon discontinuation); pancreatitis; peptic ulcer with possible perforation and hemorrhage; ulcerative esophagitis.

Metabolic

Negative nitrogen balance due to protein catabolism.

Musculoskeletal

Aseptic necrosis of femoral and humeral heads; loss of muscle mass; muscle weakness; osteoporosis; pathologic fracture of long bones; steroid myopathy; tendon rupture; vertebral compression fractures.

Neurological

Convulsions; headache; increased intracranial pressure with papilledema (pseudotumor cerebri) usually following discontinuation of treatment; psychic disorders; vertigo.

Ophthalmic

Exophthalmos; glaucoma; increased intraocular pressure; posterior subcapsular cataracts.

Other

Increased appetite; malaise; nausea; weight gain.

REPORTS OF SUSPECTED PREDNISOLONE SIDE EFFECTS / ADVERSE REACTIONS

Possible Prednisolone side effects / adverse reactions in 18 year old female

Reported by a physician from India on 2011-07-05

Patient: 18 year old female weighing 50.0 kg (110.0 pounds)

Reactions: Abdominal Pain, Vomiting, Headache, Pyrexia

Adverse event resulted in: hospitalization, disablity

Suspect drug(s):
Prednisolone
    Dosage: 7.5 mg
    Administration route: Oral

Gammaplex
    Dosage: 1000mg/kg
    Indication: Idiopathic Thrombocytopenic Purpura
    Start date: 2010-05-24

Possible Prednisolone side effects / adverse reactions in 56 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-03

Patient: 56 year old male

Reactions: Lymphoproliferative Disorder

Suspect drug(s):
Tacrolimus
    Indication: Immunosuppression
    Start date: 1998-01-01

Methylprednisolone
    Indication: Immunosuppression
    Start date: 1998-01-01

Mycophenolate Mofetil
    Indication: Transplant Rejection
    Start date: 2007-01-01
    End date: 2010-03-01

Prednisolone
    Indication: Immunosuppression
    Start date: 1998-01-01

Possible Prednisolone side effects / adverse reactions in 49 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-10-03

Patient: 49 year old male

Reactions: Toxoplasmosis, Grand MAL Convulsion, Pneumonia Aspiration, Hemiparesis, Upper Motor Neurone Lesion, Lethargy, Decreased Appetite

Adverse event resulted in: death, hospitalization

Suspect drug(s):
Prednisolone
    Indication: Immunosuppression
    Start date: 2003-01-01

Cotrim
    Indication: Immunosuppression
    Start date: 2003-01-01

Dexmethasone
    Indication: Immunosuppression

Mycophenolate Mofetil
    Indication: Immunosuppression
    Start date: 2004-01-01

Tacrolimus
    Indication: Immunosuppression
    Start date: 2003-01-01
    End date: 2008-01-01