Prednisolone Sodium Phosphate, USP, Oral Solution is a dye free, colorless to light straw colored, bubblegum flavored solution. Each 5 mL (teaspoonful) of Prednisolone Sodium Phosphate, USP, Oral Solution contains 6.7 mg prednisolone sodium phosphate (5 mg prednisolone base) in a palatable, aqueous vehicle. Prednisolone Sodium Phosphate, USP, Oral Solution also contains dibasic sodium phosphate, edetate disodium, methylparaben, purified water, sodium biphosphate, sorbitol, and bubblegum flavor. Prednisolone sodium phosphate occurs as white or slightly yellow, friable granules or powder. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.
Prednisolone Sodium Phosphate, USP, Oral Solution is indicated in the following conditions:
1. Allergic States
Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in adult and pediatric populations with: seasonal or perennial allergic rhinitis; asthma; contact dermatitis, atopic dermatitis, serum sickness; drug hypersensitivity reactions.
2. Dermatologic Diseases
Pemphigus; bullous dermatitis herpetiformis; severe erythema multiforme (Stevens-Johnson syndrome);exfoliative erythroderma; mycosis fungoides.
3. Edematous States
To induce diuresis or remission of proteinuria in nephrotic syndrome in adults with lupus erythematosus and in adults and pediatric populations, with idiopathic nephrotic syndrome, without uremia.
4. Endocrine Disorders
Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the first choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance); congenital adrenal hyperplasia; hypercalcemia associated with cancer; nonsuppurative thyroiditis.
5. Gastrointestinal Diseases
To tide the patient over a critical period of the disease in: ulcerative colitis; regional enteritis.
6. Hematologic Disorders
Idiopathic thrombocytopenic purpura in adults;selected cases of secondary thrombocytopenia; acquired (autoimmune) hemolytic anemia; pure red cell aplasia; Diamond-Blackfan anemia.
7. Neoplastic Diseases
For the treatment of acute leukemia and aggressive lymphomas in adults and children.
8. Nervous System
Acute exacerbations of multiple sclerosis.
9. Ophthalmic Diseases
Uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids; temporal arteritis; sympathetic ophthalmia.
10. Respiratory Diseases
Symptomatic sarcoidosis;idiopathic eosinophilic pneumonias; fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy; asthma (as distinct from allergic asthma listed above under "Allergic States"), hypersensitivity pneumonitis, idiopathic pulmonary fibrosis, acute exacerbations of chronic obstructive pulmonary disease (COPD), and Pneumocystis carinii pneumonia (PCP) associated with hypoxemia occurring in an HIV (+) individual who is also under treatment with appropriate anti-PCP antibiotics.Studies support the efficacy of systemic corticosteroids for the treatment of these conditions:allergic bronchopulmonary aspergillosis, idiopathic bronchiolitis obliterans with organizing pneumonia.
11. Rheumatic Disorders
As adjunctive therapy for short term administration (to tide the patient over an acute episode or exacerbation) in: psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low dose maintenance therapy); ankylosing spondylitis; acute and subacute bursitis; acute nonspecific tenosynovitis;acute gouty arthritis;epicondylitis. For the treatment of systemic lupus erythematosus, dermatomyositis (polymyositis), polymyalgia rheumatica, Sjogren's syndrome, relapsing polychondritis, and certain cases of vasculitis.
Tuberculous meningitis with subarachnoid block or impending block, tuberculosis with enlarged mediastinal lymph nodes causing respiratory difficulty, and tuberculosis with pleural or pericardial effusion (appropriate antituberculous chemotherapy must be used concurrently when treating any tuberculosis complications); Trichinosis with neurologic or myocardial involvement; acute or chronic solid organ rejection (with or without other agents).
Published Studies Related to Prednisolone
Effect of timing and route of methylprednisolone administration during pediatric
cardiac surgical procedures. 
cardiopulmonary bypass (CPB) prime... CONCLUSIONS: Methylprednisolone administration at anesthesia induction was
Combined oral prednisolone and heparin versus heparin: the effect on peripheral
NK cells and clinical outcome in patients with unexplained recurrent miscarriage.
A double-blind placebo randomized controlled trial. 
CONCLUSION: The addition of prednisolone to heparin and low dose aspirin might be
A comparison of the effects of methylprednisolone and tenoxicam on pain, edema,
and trismus after impacted lower third molar extraction. 
CONCLUSIONS: Preoperative administration of 80 mg methylprednisolone achieves
Effects of long-acting bronchodilators and prednisolone on inspiratory lung
function parameters in stable COPD. 
dyspnea (visual analogÂ scale (VAS)) and clinical COPD questionnaire (CCQ)... CONCLUSIONS: After a single dose of long-acting bronchodilator salmeterol,
Efficiency of bupivacaine versus lidocaine and methylprednisolone versus placebo
to reduce postoperative pain and swelling after surgical removal of mandibular
third molars: a randomized, double-blinded, crossover clinical trial. 
swelling after surgical removal of mandibular third molars... CONCLUSIONS: Bupivacaine combined with methylprednisolone reduced the
Clinical Trials Related to Prednisolone
Prednisolone Priming Study in Patients With Chronic Hepatitis B [Recruiting]
To investigate whether ALT rebound following corticosteroid priming enhances response to
The primary endpoint will be the 1-year HBe-Ag seroconversion rate with or without
A summary table will be presented as frequency tables for categorical variables as number,
and percentage, whereas descriptive tables for continuous variables as number, mean ± SD and
median (minimum, maximum). All statistical assessments will be two-sided and evaluated at
significance level of 0. 05. Continuous variables will be analyzed using t-test, or ANOVA,
and categorical variables will be analyzed using chi-square or Fisher's exact test. A
non-parametric method, Wilcoxon rank-sum or sign-rank tests will be conducted for
continuous, and categorical variables if data is far from normal distribution.
Biomarkers of Prednisolone Treatment (P05888) [Completed]
- To identify a biomarker or biomarker-set for the adverse metabolic effects of various
doses of prednisolone treatment.
- To describe the PK of prednisolone and PD of a series of biomarkers.
- To identify biomarkers that reflect side effects of prednisolone.
- To elucidate part of the mechanisms by which prednisolone induces metabolic changes.
The Efficacy of Three Months-prednisolone Therapy for Chronic Eosinophilic Pneumonia [Completed]
A comparison of 3 months-prednisolone administration with 6 months-prednisolone therapy in
the treatment of chronic eosinophilic pneumonia. Three months-prednisolone administration
may be as effective as 6 months-therapy.
A Comparison of Three Different Formulations of Prednisolone Acetate 1% [Completed]
A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte [Completed]
The purpose of this study is to demonstrate the bioequivalence of the combination test
agent, prednisolone acetate 1. 0% and tobramycin 0. 3% ophthalmic suspension compared to
PredForte (prednisolone acetate 1. 0%) ophthalmic suspension. Bioequivalence will be measured
by comparing aqueous humor concentrations of prednisolone acetate.
Reports of Suspected Prednisolone Side Effects
Pneumocystis Jiroveci Pneumonia (98),
Respiratory Failure (94),
Herpes Zoster (89),
Infection (86), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 8 ratings/reviews, Prednisolone has an overall score of 6.50. The effectiveness score is 8.50 and the side effect score is 6.75. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Prednisolone review by 26 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || SLE (Lupus), Rheumatoid Arthritis|
|Dosage & duration:|| || 10mg to 5mg taken once daily (morning) for the period of 8 weeks|
|Other conditions:|| || Degenerative bone, joint and disc disease|
|Other drugs taken:|| || Ortho Tri Cyclen Lo|
|Benefits:|| || Severe pain in entire body was gone, and I mean GONE. I felt like I was a little kid again, able to do anything. I also had increased energy.|
|Side effects:|| || Slight weight gain. |
|Comments:|| || I take this medicine on and off, usually for a duration of about two months on a very low dosage. |
Prednisolone review by 52 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || lupus-like systemic autoimmune condition|
|Dosage & duration:|| || 30mg max / 7.5 mg min so far taken daily for the period of 3 years, ongoing|
|Other conditions:|| || underactive thyroid|
|Other drugs taken:|| || levo-thyroxine, lansoprazole when dose above 12.5mg to protect stomach|
|Benefits:|| || keeps me alive during flare-ups! (They incl pericarditis & pleural effusions, ie inflammation of the lining around the heart and lungs – involving LOTS of fluid for which there isn't space, leading to heart failure and breathlessness - nice...) I can more or less live a normal life, apart from at the start of a flare (and spending hours researching online!).|
|Side effects:|| || rampant hunger at high dose (above 25mg) - but, with discipline (and vanity!) have managed to keep my weight within 4lbs of my prior weight; SLIGHT rounding of face (I'm lucky!); bodily skin thinning, particularly evident on my shins (I use Nivea CoQ10 firming lotion - fab – all over, 2x daily, and am about to start taking Qsilica to see if it'll help); most importantly...slight bone density loss when tested 20 mths ago (next DEXA scan is later this month) but as well as exercising, I take daily organic calcium, magnesium, L-Lysine (amino acid), boron, zinc, 2 gms slow release vit C, marine collagen, plus am trying to eat an alkaline diet to keep body at neutral pH (see SaveOurBones online - I have no affiliation!).|
|Comments:|| || For good reasons (not typical lupus, plus 'you know your body best'), my Doc and Consultant basically leave me to decide my dosage! After 3 years I have learnt that when I have the 1st definite signs of a flare-up (pericarditis symptom, ie pressure in neck when bending over), I need to put the dose up to 30mg straight away - from trial and error, anything less just doesn't work, ie putting dose up to e.g. 15mg, then 20mg, then 25mg gives the flare-up more time to really get hold of me! Am trying to decide whether to take 'steroid-sparing' drug Azathioprine as well...v hard decision as it's a serious immune suppressant and has scary side-effects. Hey ho! (Once tried 35mg for a couple of days when 30mg wasn't quite sorting it, and got tingly lips - checked online and thought it could be a sign of calcium deficiency; called Doc, he agreed (!) so went back down to 30mg and was fine.)|
Prednisolone review by 33 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || r/a|
|Dosage & duration:|| || 60mg taken daily for the period of weeks|
|Other conditions:|| || none|
|Other drugs taken:|| || methatrex|
|Benefits:|| || first cople week felt great swelling down no pain fulll of energy wanted to go jogging |
|Side effects:|| || big fat face,body ectdepressed mood swings up and down dont want to go out the house gained about a stone only been on it for 4 weeks some and pain swelling back feeling ill and night swets and spots over face and body feeling iritabill and can not think straght could go on |
|Comments:|| || start on 60mg second week 50mg third week 40 forth week 30 and had anough|
Page last updated: 2015-08-10