PRED-MILD SUMMARY
PRED MILD®
(prednisolone acetate ophthalmic suspension, USP) 0.12%
PRED MILD® (prednisolone acetate ophthalmic suspension, USP) 0.12% is a topical anti-inflammatory agent for ophthalmic use.
PRED MILD® is indicated for the treatment of mild to moderate noninfectious allergic and inflammatory disorders of the lid, conjunctiva, cornea, and sclera (including chemical and thermal burns).
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NEWS HIGHLIGHTS
Published Studies Related to Pred-Mild (Prednisolone Ophthalmic)
Difluprednate ophthalmic emulsion 0.05% for postoperative inflammation and pain. [2009.01]
PURPOSE: To assess the efficacy and safety of difluprednate ophthalmic emulsion 0.05% (Durezol) 2 or 4 times a day compared with those of a placebo in the treatment of inflammation and pain associated with ocular surgery. SETTING: Twenty-six clinics in the United States... CONCLUSIONS: Difluprednate given 2 or 4 times a day cleared postoperative inflammation and reduced pain rapidly and effectively. There were no serious ocular adverse events. Fewer adverse events were reported in the difluprednate-treated groups than in the placebo group.
Efficacy of methylprednisolone injected into the masseter muscle following the surgical extraction of impacted lower third molars. [2008.03]
The aim of this study was to demonstrate the efficacy of methylprednisolone, as a single 40-mg dose, injected into the masseter muscle upon completion of extraction of impacted lower third molars. A prospective, randomized cross-over study was made of 35 healthy patients... The results obtained show that 40 mg of methylprednisolone injected into the masseter muscle in the immediate postoperative period reduces swelling, trismus and pain.
Methylprednisolone pulse therapy for patients with moderately severe Graves' orbitopathy: a prospective, randomized, placebo-controlled study. [2008.02]
OBJECTIVE: To assess whether methylprednisolone (MP) pulse therapy is efficacious in the treatment of moderately severe Graves' orbitopathy (GO). DESIGN: Prospective, placebo (PL)-controlled, double-blind, randomized study... CONCLUSIONS: In spite of the small number of patients, a significant difference in outcome was observed between MP- and PL-treated patients. We conclude that MP pulse therapy appears to be an effective treatment for active, moderately severe GO.
Clinical comparison of two topical prednisolone acetate 1% formulations in reducing inflammation after cataract surgery. [2007.10]
PURPOSE: To compare the efficacy of two formulations of prednisolone acetate 1% in reducing postoperative inflammation in patients having primary phacoemulsification surgery with IOL implantation... CONCLUSIONS: In this study of routine cataract patients, both prednisolone acetate 1% formulations are comparably effective and safe when administered for the reduction of inflammation after phacoemulsification surgery with IOL implantation.
High-dose intravenous methylprednisolone in recent traumatic optic neuropathy; a randomized double-masked placebo-controlled clinical trial. [2007.09]
BACKGROUND: To compare the effect of high-dose intravenous corticosteroid therapy with placebo in the treatment of recent traumatic optic neuropathy (TON)... CONCLUSIONS: Our study confirms earlier findings that there is no difference in visual acuity improvement between intravenous high-dose corticosteroids and placebo in treatment of recent TNO.
Clinical Trials Related to Pred-Mild (Prednisolone Ophthalmic)
Evaluation of the Efficacy of Topical Ophthalmic Steroids in a Modified Conjunctival Allergen Challenge Model [Active, not recruiting]
The purpose of the study is to determine whether prednisolone acetate 1% ophthalmic
suspension is effective in preventing signs and symptoms of allergic conjunctivitis in
comparison with prednisolone acetate 0. 12% ophthalmic suspension, loteprednol etabonate 0. 2%
ophthalmic suspension and placebo in a modified conjunctival allergen challenge (CAC) model.
Scandinavian Bell's Palsy Study [Completed]
The main objective of this study is to study the effects of prednisolone and valaciclovir,
with equal importance, compared to placebo for the treatment of Bell´s palsy. The combination
of prednisolone and valaciclovir will also be studied.
A Bioequivalence Study of Tobramycin and Prednisolone Acetate Compared to PredForte [Completed]
A Comparison of Three Different Formulations of Prednisolone Acetate 1% [Recruiting]
The Efficacy of Three Months-Prednisolone Therapy for Chronic Eosinophilic Pneumonia [Recruiting]
A comparison of 3 months-prednisolone administration with 6 months-prednisolone therapy in
the treatment of chronic eosinophilic pneumonia. Three months-prednisolone administration
may be as effective as 6 months-therapy.
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