Published Studies Related to Pred Forte (Prednisolone Ophthalmic)
A multicenter randomized controlled fellow eye trial of pulse-dosed difluprednate 0.05% versus prednisolone acetate 1% in cataract surgery. [2011.10]
PURPOSE: To compare the effects of 2 corticosteroids on corneal thickness and visual acuity after cataract surgery. DESIGN: Multicenter, randomized, contralateral-eye, double-masked trial... CONCLUSIONS: In this high-dose pulsed-therapy regimen, difluprednate reduced inflammation more effectively than prednisolone acetate, resulting in more rapid return of vision. Difluprednate was superior at protecting the cornea and reducing macular thickening after cataract surgery. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. [2011.01]
PURPOSE: To compare the efficacy of intravitreal injection of clindamycin and dexamethasone with classic treatment for ocular toxoplasmosis... CONCLUSIONS: Intravitreal injection of clindamycin and dexamethasone may be an acceptable alternative to the classic treatment in ocular toxoplasmosis. It may offer the patient more convenience, a safer systemic side effect profile, greater availability, and fewer follow-up visits and hematologic evaluations. Copyright (c) 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.
Methylprednisolone applied directly to the round window reduces dizziness after cochlear implantation: a randomized clinical trial. 
This prospective, double-blind controlled, randomized clinical trial of 43 adults showed that topical methylprednisolone applied to the round window during cochlear implantation was effective in protecting inner ear function. Postoperative vestibular disturbance was significantly lower in the steroid group (5%) than the control group (29%)...
Durezol (Difluprednate Ophthalmic Emulsion 0.05%) compared with Pred Forte 1% ophthalmic suspension in the treatment of endogenous anterior uveitis. [2010.10]
PURPOSE: The aim of this study was to evaluate the efficacy and safety of difluprednate ophthalmic solution 0.05% (Durezol; Alcon Laboratories, Fort Worth, TX) compared with prednisolone acetate ophthalmic suspension 1% (Pred Forte; Allergan, Inc., Irvine, CA) for endogenous anterior uveitis... CONCLUSIONS: Difluprednate administered QID is at least as effective as prednisolone administered 8x/day in resolving the inflammation and pain associated with endogenous anterior uveitis. Difluprednate provides effective treatment for anterior uveitis and requires less frequent dosing than prednisolone acetate. Clinical trial registration: Trial NCT00501579 was registered at the National Institutes of Health Registry in July 2007 ( http://clinicaltrials.gov/ct2/show/NCT00501579?term=sirion&rank=4 ).
Comparison of orbital floor triamcinolone acetonide and oral prednisolone for cataract surgery management in patients with non-infectious uveitis. [2010.05]
PURPOSE: To compare orbital floor triamcinolone acetonide and oral prednisolone in cataract surgery in patients with chronic non-infectious uveitis with regard to visual outcome, postoperative inflammation and macular edema... CONCLUSIONS: A single intraoperative orbital floor injection of triamcinolone acetonide is as effective on postoperative inflammation, macular edema, and visual outcome as a 4-week course of postoperative oral prednisolone in cataract surgery with IOL implantation in uveitis patients.
Clinical Trials Related to Pred Forte (Prednisolone Ophthalmic)
Prednisone Timed-Release Tablet (TRT) Study: TRT Formulation of Prednisone Compared to Standard Prednisone in Patients With Rheumatoid Arthritis [Completed]
The objective of this study is to investigate if low doses of prednisone TRT, given at night
and, with active drug release at 2 am, are more effective in controlling joint stiffness, and
other disease symptoms of rheumatoid arthritis than standard prednisone given in the morning.
Treatment duration per patient takes 12 months (the double-blind comparative study takes 3
months; 9 months subsequent open treatment on the TRT-medication).
Prednisone-Placebo vs Prednisone-Valacyclovir in Bell´s Palsy [Completed]
Since steroids carry a moderate beneficial effect in Bell's palsy, and to address this
question, valacyclovir was added to prednisone for the treatment of this condition.
Subcutaneous Velcade Plus Oral Melphalan and Prednisone or Plus Cycloposphamide and Prednisone or Plus Prednisone [Recruiting]
This protocol is a single-arm, three-cohort, phase II multicenter study designed to assess
the safety and the efficacy of three all-oral combinations: Velcade with continuous low-dose
melphalan and prednisone (VMP) or with continuous low-dose cyclophosphamide and prednisone
(VCP) or Velcade with low-dose prednisone could be effective and well tolerated (VP).
Lenalidomide and Dexamethasone Versus Melphalan Prednisone and Lenalidomide Versus Cyclophosphamide, Prednisone and Lenalidomide in Elderly Multiple Myeloma Patients [Recruiting]
This is a multicenter, randomized, controlled, 3 arm parallel group study designed to
evaluate the efficacy and safety of three all-oral combinations: lenalidomide with
dexamethasone (Rd) in comparison with lenalidomide in association with MP (MPR) and
lenalidomide in association with cyclophosphamide - prednisone (CPR) in newly diagnosed
symptomatic MM patients. This protocol also provides a substudy designed to observe
asymptomatic patients excluded to the protocol that in any case could be inserted in the
Study Comparing Two Tapering Strategies of Prednisone in Myasthenia Gravis [Recruiting]
Pathology - Generalized myasthenia gravis (MG) is cause of muscle weakness that can have a
significant impact on daily life activity but can also be, when respiratory or bulbar
muscles are involved, life-threatening.
Rationale - Additionally to thymectomy, which indication of is still debated in absence of
thymoma, the long-term treatment of generalized myasthenia gravis includes usually
prednisone and azathioprine. However, the most used scheme for prescribing and tapering
corticosteroid in MG resulted in a very important cumulative dose of prednisone. Indeed, at
twelve month, more than 50 percent of patients are still daily treated with at least 18 mg
of prednisone and the proportion of patients who are in remission and no longer taking
prednisone is very low (Palace and NEWSOM Davis, Neurology 1998). Prolonged corticosteroid
therapy is accompanied with various and major side effects, hypertension, osteoporosis,
weight gain, glaucoma. Therefore, tapering, eventually discontinuing, prednisone earlier is
a relevant therapeutic goal.
For this reason, the investigators will compare to the standard one, a strategy consisting
of a rapid decrease in corticosteroid.
Objective - To assess whether, in patients with generalized MG requiring a long-term
treatment with corticosteroids and azathioprine, that the strategy of rapid tapering allows
discontinuing more rapidly the prednisone for equivalent efficacy than the classical
Reports of Suspected Pred Forte (Prednisolone Ophthalmic) Side Effects
Intraocular Pressure Increased (14),
Drug Ineffective (11),
Vision Blurred (9),
Eye Oedema (7),
Visual Acuity Reduced (6),
Corneal Opacity (5),
Condition Aggravated (4),
Eye Irritation (3), more >>