Precedex® (dexmedetomidine hydrochloride injection) is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride.
Intensive Care Unit Sedation
Precedex® is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.
Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation.
Precedex is indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures.
Media Articles Related to Precedex (Dexmedetomidine)
Novel Sedation Agent for Colonoscopy Meets Phase III Endpoints
Source: MedPageToday.com - medical news plus CME for physicians [2016.10.21]
(MedPage Today) -- Remimazolam shows advantages over midazolam
High quality MRIs without sedation are possible in severely affected children with autism
Source: Autism News From Medical News Today [2016.07.21]
UC Davis researchers have found a way to get MRI images of children with autism spectrum disorder (ASD) and intellectual disability without sedating them first using the principles of applied...
Remimazolam Allows Speedy Recovery After Colonoscopy
Source: Medscape Anesthesiology Headlines [2016.10.21]
For outpatient colonoscopy, the new benzodiazepine provides adequate sedation, and recovery is faster than with the alternative, owing to its short half-life, new research shows.
Medscape Medical News
Transcarotid TAVR May Often Avoid General Anesthesia
Source: theheart.org | Medscape Cardiology Headlines [2016.10.18]
Using local anesthesia with conscious sedation might have cut the risk of periprocedural strokes a small transcarotid-TAVR series; the patients had severe peripheral vascular disease.
Heartwire from Medscape
Published Studies Related to Precedex (Dexmedetomidine)
Effect of intrathecal dexmedetomidine on spinal morphine analgesia in patients
with refractory cancer pain. 
analgesia in patients with refractory cancer pain... CONCLUSIONS: Intrathecal administration of dexmedetomidine and morphine reduced
Comparison of dexmedetomidine and propofol for conscious sedation in awake
craniotomy: a prospective, double-blind, randomized, and controlled clinical
sedation in awake craniotomy... CONCLUSIONS: Either DEX or PRO can be effectively and safely used for conscious
Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A
double-blind, randomized and placebo-controlled study. 
CONCLUSION: It appears that DEX could reverse the reduced plasma concentrations
Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements: a randomized control trial. [2011.09.28]
PURPOSE: We hypothesized that a high dose of dexmedetomidine (1 mug/kg/h) could reduce postoperative analgesic requirements of patients... CONCLUSIONS: Among this small patient cohort, perioperative infusion of dexmedetomidine (1 mug/kg/h) resulted in antinociception without severe side effects. These results suggest that this method could be of interest with respect to improving postoperative pain status.
A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats. [2011.07]
OBJECTIVE: To determine the effect of ondansetron on the incidence of vomiting in cats pre-medicated with dexmedetomidine and buprenorphine.
Clinical Trials Related to Precedex (Dexmedetomidine)
Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery [Completed]
Primary Hypothesis: The use of a Precedex infusion, in addition to propofol during surgery,
will improve patient management through the anesthesia postoperative recovery period
determined by improvement in patients? tolerance of the endotracheal tube.
Secondary hypothesis: The use of a Precedex infusion, in addition to propofol during surgery
will provide improved hemodynamic stability.
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft [Completed]
The aim of the present study is to compare the antiarrhythmic and myocardial protective
effect between lidocaine, dexmedetomidine, and their combined infusion in subjects
undergoing coronary artery bypass graft.
Dexmedetomidine as an Adjuvant for Sub-Tenon's Anesthesia [Completed]
The investigator evaluated the motor and sensory block durations and the postoperative
analgesic effects of adding dexmedetomidine to levobupivacaine for sub-Tenon's anesthesia in
patients undergoing vitreoretinal surgery. Motor and sensory block durations were
considered as a primary endpoint.
The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children [Completed]
Dexmedetomidine is a sedative drug that has many benefits when given to children under
anesthesia, such as improved pain relief and reduced agitation following their surgery. It
is usually given as an intravenous infusion over 10 minutes, to avoid the changes in heart
rate and blood pressure that are occasionally seen when it is administered more quickly.
However, this is often infeasible and usually inconvenient. The investigators aim to
determine the dose of dexmedetomidine that can be given rapidly (over 5 seconds) without
causing significant changes in heart rate and blood pressure. This will be the only study
Dexmedetomidine in Spinal Anesthesia [Completed]
Patients were randomized into two groups, A group and B group. A group and B group patients
are injected intravenous dexmedetomidine after intrathecal injection (IT) of heavy
bupivacaine and injected intravenous dexmedetomidine before IT of heavy bupivacaine,
The investigators will compare of hemodynamics and patient's comfortability between two
Reports of Suspected Precedex (Dexmedetomidine) Side Effects
Cardiac Arrest (6),
Procedural Complication (4),
Musculoskeletal Stiffness (3),
Blood Creatine Phosphokinase Increased (2),
Hepatitis Fulminant (2),
Peripheral Circulatory Failure (2), more >>