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Precedex (Dexmedetomidine Hydrochloride) - Summary

 
 



PRECEDEX SUMMARY

Precedex (dexmedetomidine hydrochloride injection) is a sterile, nonpyrogenic solution suitable for intravenous infusion following dilution. Dexmedetomidine hydrochloride is the S-enantiomer of medetomidine and is chemically described as (+)-4-(S)-[1-(2,3-dimethylphenyl)ethyl]-1H-imidazole monohydrochloride.

Intensive Care Unit Sedation

Precedex is indicated for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care setting. Precedex should be administered by continuous infusion not to exceed 24 hours.

Precedex has been continuously infused in mechanically ventilated patients prior to extubation, during extubation, and post-extubation. It is not necessary to discontinue Precedex prior to extubation.

Procedural Sedation

Precedex is indicated for sedation of non-intubated patients prior to and/or during surgical and other procedures.


See all Precedex indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Precedex (Dexmedetomidine)

Effect of intrathecal dexmedetomidine on spinal morphine analgesia in patients with refractory cancer pain. [2014]
analgesia in patients with refractory cancer pain... CONCLUSIONS: Intrathecal administration of dexmedetomidine and morphine reduced

Comparison of dexmedetomidine and propofol for conscious sedation in awake craniotomy: a prospective, double-blind, randomized, and controlled clinical trial. [2013]
sedation in awake craniotomy... CONCLUSIONS: Either DEX or PRO can be effectively and safely used for conscious

Effect of dexmedetomidine on plasma brain-derived neurotrophic factor: A double-blind, randomized and placebo-controlled study. [2013]
CONCLUSION: It appears that DEX could reverse the reduced plasma concentrations

Perioperative infusion of dexmedetomidine at a high dose reduces postoperative analgesic requirements: a randomized control trial. [2011.09.28]
PURPOSE: We hypothesized that a high dose of dexmedetomidine (1 mug/kg/h) could reduce postoperative analgesic requirements of patients... CONCLUSIONS: Among this small patient cohort, perioperative infusion of dexmedetomidine (1 mug/kg/h) resulted in antinociception without severe side effects. These results suggest that this method could be of interest with respect to improving postoperative pain status.

A randomized, blinded, controlled trial of the antiemetic effect of ondansetron on dexmedetomidine-induced emesis in cats. [2011.07]
OBJECTIVE: To determine the effect of ondansetron on the incidence of vomiting in cats pre-medicated with dexmedetomidine and buprenorphine.

more studies >>

Clinical Trials Related to Precedex (Dexmedetomidine)

Comparison of Propofol to Precedex With Propofol for Emergence and Recovery in Patients Having Craniotomy Surgery [Completed]
Primary Hypothesis: The use of a Precedex infusion, in addition to propofol during surgery, will improve patient management through the anesthesia postoperative recovery period determined by improvement in patients? tolerance of the endotracheal tube. Secondary hypothesis: The use of a Precedex infusion, in addition to propofol during surgery will provide improved hemodynamic stability.

Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft [Completed]
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.

Dexmedetomidine as an Adjuvant for Sub-Tenon's Anesthesia [Completed]
The investigator evaluated the motor and sensory block durations and the postoperative analgesic effects of adding dexmedetomidine to levobupivacaine for sub-Tenon's anesthesia in patients undergoing vitreoretinal surgery. Motor and sensory block durations were considered as a primary endpoint.

The Bolus Dose of Dexmedetomidine (ED50) That Avoids Hemodynamic Compromise in Children [Completed]
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. It is usually given as an intravenous infusion over 10 minutes, to avoid the changes in heart rate and blood pressure that are occasionally seen when it is administered more quickly. However, this is often infeasible and usually inconvenient. The investigators aim to determine the dose of dexmedetomidine that can be given rapidly (over 5 seconds) without causing significant changes in heart rate and blood pressure. This will be the only study specific intervention.

Dexmedetomidine in Spinal Anesthesia [Completed]
Patients were randomized into two groups, A group and B group. A group and B group patients are injected intravenous dexmedetomidine after intrathecal injection (IT) of heavy bupivacaine and injected intravenous dexmedetomidine before IT of heavy bupivacaine, respectively. The investigators will compare of hemodynamics and patient's comfortability between two groups.

more trials >>

Reports of Suspected Precedex (Dexmedetomidine) Side Effects

Cardiac Arrest (6)Bradycardia (5)Procedural Complication (4)Agitation (3)Hyperthermia (3)Musculoskeletal Stiffness (3)Blood Creatine Phosphokinase Increased (2)Acidosis (2)Hepatitis Fulminant (2)Peripheral Circulatory Failure (2)more >>


Page last updated: 2015-08-10

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