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Ponstel (Mefenamic Acid) - Summary

 

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Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
  • PONSTEL® is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (See WARNINGS).


Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).

 

PONSTEL SUMMARY

PONSTEL

Ponstel® (mefenamic acid) is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each blue-banded, ivory capsule contains 250 mg of mefenamic acid for oral administration.

Carefully consider the potential benefits and risks of PONSTEL and other treatment options before deciding to use PONSTEL. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

PONSTEL is indicated:

  • For relief of mild to moderate pain in patients ≥14 years of age, when therapy will not exceed one week (7 days).
  • For treatment of primary dysmenorrhea.


PONSTEL NEWS HIGHLIGHTS

Published Studies Related to Ponstel (Mefenamic Acid)

Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea. [2006.05]

Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts. [2005.08]

Randomized controlled trial of mefenamic acid vs paracervical block for relief of pain for outpatient uterine curettage. [2005.07]

Effect of mefenamic acid on controlling irregular uterine bleeding in DMPA users. [2004.10]

Double-blind study to evaluate efficacy and safety of meloxicam 7.5 mg and 15 mg versus mefenamic acid 1500 mg in the treatment of primary dysmenorrhea. [2004.07]

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Page last updated: 2006-11-04

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