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Ponstel (Mefenamic Acid) - Summary

 
 



Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk (See WARNINGS).
  • PONSTEL® is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery (See WARNINGS).


Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (See WARNINGS).

 

PONSTEL SUMMARY

PONSTEL

Ponstel (mefenamic acid) is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). Each blue-banded, ivory capsule contains 250 mg of mefenamic acid for oral administration.

Carefully consider the potential benefits and risks of PONSTEL and other treatment options before deciding to use PONSTEL. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

PONSTEL is indicated:

  • For relief of mild to moderate pain in patients ≥14 years of age, when therapy will not exceed one week (7 days).
  • For treatment of primary dysmenorrhea.



See all Ponstel indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Ponstel (Mefenamic Acid)

Efficacy of mefenamic acid and hyoscine for pain relief during saline infusion sonohysterography in infertile women: a double blind randomized controlled trial. [2011.04]
OBJECTIVES: To evaluate the efficacy and level of satisfaction from mefenamic acid and hyoscine when used for pain relief during saline infusion sonohysterography... CONCLUSION: There is no benefit in using mefenamic acid and hyoscine in the prevention of pain occurring from SIS. Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved.

Single dose oral mefenamic acid for acute postoperative pain in adults. [2011]
CONCLUSIONS: Oral mefenamic acid 500 mg was effective at treating

Comparison of efficacy of oral drotaverine plus mefenamic acid with paracervical block and with intravenous sedation for pain relief during hysteroscopy and endometrial biopsy. [2009.06]
BACKGROUND: Office hysteroscopy with endometrial biopsy is usually the first investigation for abnormal uterine bleeding and other uterine diseases. AIMS: To evaluate the effect of oral drotaverine with mefenamic acid on pain perception during hysteroscopy and endometrial biopsy and to compare it with that of paracervical block using 1% lignocaine and with that of intravenous sedation using diazepam with pentazocine. SETTINGS AND DESIGN: Outpatient gynecological department and open randomized trial... CONCLUSIONS: Oral drotaverine with mefenamic acid is effective in women undergoing hysteroscopy and endometrial biopsy.

Comparison of the effectiveness of fennel and mefenamic acid on pain intensity in dysmenorrhoea. [2006.05]
A study in Kerman, Islamic Republic of Iran in 2002 compared the effectiveness of fennel and mefenamic acid on pain relief in primary dysmenorrhoea. Two groups of high-school girls (mean age 13 years) suffering dysmenorrhoea were randomized to receive fennel extract (n = 55) or mefenamic acid (n = 55) for 2 months...

Randomised comparative trial of the levonorgestrel intrauterine system and mefenamic acid for the treatment of idiopathic menorrhagia: a multiple analysis using total menstrual fluid loss, menstrual blood loss and pictorial blood loss assessment charts. [2005.08]
OBJECTIVE: To compare the efficacy and tolerability of the levonorgestrel intrauterine system (LNG IUS) with mefenamic acid in the management of objective idiopathic menorrhagia. DESIGN: Phase III, Single centre, open, randomised, comparative, parallel group study. SETTING: District General Hospital in the United Kingdom. POPULATION: Fifty-one women with objective menorrhagia... CONCLUSIONS: Both the LNG IUS and mefenamic acid significantly decreased menstrual blood loss, TMFL and PBAC scores. The LNG IUS produced greater reductions in all parameters than mefenamic acid. Comparison of the different measurements suggests that TMFL assessment may be an easier and a more relevant measure of symptom severity than menstrual blood loss.

more studies >>

Clinical Trials Related to Ponstel (Mefenamic Acid)

The Efficacy of Ayurved Siriraj Prasaplai for Treatment Primary Dysmenorrhea [Recruiting]
Ayurved Siriraj Prasaplai is a Thai traditional herbal drug for pain treatment. Mostly it was used for antipain during menstruation or dysmenorrhea. This drug has been described by alternative medical doctor for treatment of primary dysmenorrhea for more than 10 years and showed clinical satisfied response. From review about this agent, it does not have clinical trial to prove its efficacy. So the author produce this research to study in efficacy of Ayurved Siriraj Prasaplai.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ponstel has an overall score of 9. The effectiveness score is 9.33 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ponstel review by 25 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   menstrual cramps
Dosage & duration:   250 mg. taken every 8-12 hours for the period of 3-4 days
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I was used to having cramps so badly that they would leave me balled up in bed for at least 2 days. The Ponstel doesn't take the pain away completely, but takes the edge off so much that normal activities were possible. Definitely a miracle medication!!
Side effects:   Heavier bleeding and clotting than normal.
Comments:   I took 2 pills at the onset of my menstrual cramps and then every 8-12 hours took 1 pill as needed for about 3-4 days until cramps were over. If cramps are bad, make sure to take every 8 hours on the dot because the medication stops working suddenly and unfortunately takes about an hour to an hour and a half to kick back in.. if cramps are only moderate, taking every 12 hours is okay.

 

Ponstel review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   1 to two tablets at first onset of pain taken once a month for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Although it did not completely rid me of my migraine it helped to dull the pain. I was actually able to go to work with a migraine instead to taking a day off to just lie still.
Side effects:   no side effects.
Comments:   At the first symptoms of a migraine I wojld pop a copule of tablets. For severe migraines I would repeat the dosage about 8 hours later. However, over time I found the medication to be less effective and ultimately stopped taking it. It seems as though my body became immune to it's effectiveness.

 

Ponstel review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   1 to two tablets at first onset of pain taken once a month for the period of 3 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Although it did not completely rid me of my migraine it helped to dull the pain. I was actually able to go to work with a migraine instead to taking a day off to just lie still.
Side effects:   no side effects.
Comments:   At the first symptoms of a migraine I wojld pop a copule of tablets. For severe migraines I would repeat the dosage about 8 hours later. However, over time I found the medication to be less effective and ultimately stopped taking it. It seems as though my body became immune to it's effectiveness.

See all Ponstel reviews / ratings >>

Page last updated: 2013-02-10

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