POLYSPORIN SUMMARY
POLYSPORIN® OPHTHALMIC OINTMENT STERILE
(bacitracin zinc and polymyxin B sulfate ophthalmic ointment, USP)
POLYSPORIN Ophthalmic Ointment (bacitracin zinc and polymyxin B sulfate ophthalmic ointment) is a sterile antimicrobial ointment for ophthalmic use. Each gram contains: bacitracin zinc equivalent to 500 bacitracin units, polymyxin B sulfate equivalent to 10,000 polymyxin B units, and white petrolatum, q. s. Bacitracin zinc is the zinc salt of bacitracin, a mixture of related cyclic polypeptides (mainly bacitracin A) produced by the growth of an organism of the licheniformis group of Bacillus subtilis var Tracy. It has a potency of not less than 40 bacitracin units per mg.
POLYSPORIN Ophthalmic Ointment is indicated for the topical treatment of superficial infections of the external eye and its adnexa caused by susceptible bacteria. Such infections encompass conjunctivitis, keratitis and keratoconjunctivitis, blepharitis and blepharoconjunctivitis.
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NEWS HIGHLIGHTS
Published Studies Related to Polysporin (Bacitracin / Polymyxin B Ophthalmic)
A RANDOMIZED CONTROLLED TRIAL COMPARING MUPIROCIN VERSUS POLYSPORIN TRIPLEa FOR THE PREVENTION OF CATHETER-RELATED INFECTIONS IN PERITONEAL DIALYSIS PATIENTS (THE MP3 STUDY). [2008.01]
BACKGROUND: Peritonitis remains the most serious complication of peritoneal dialysis (PD). Gram-positive organisms are among the most common causes of PD peritonitis; however, recent trends show increasing rates of gram-negative and fungal infections.Discussion: The results of this study will help determine if the use of P3 is superior to mupirocin ointment in the prevention of catheter-related infections and will help guide evidence-based best practices.
Clinical Trials Related to Polysporin (Bacitracin / Polymyxin B Ophthalmic)
Use of Ointments in Prevention of Catheter Related Infections in PD [Recruiting]
Peritoneal dialysis (PD) is used for the treatment of end-stage renal disease in
approximately 25% of patients requiring dialysis in Canada. The most common complication is
bacterial infection or ‘peritonitis’. Peritonitis causes severe acute abdominal pain and may
lead to failure of peritoneal dialysis treatment, hospitalization or death, particularly if
left untreated. Amongst the strategies used to prevent peritonitis, patients are instructed
on the regular use of a prophylactic ointment around the point where the catheter exits from
the body. At the present time most centers in Canada routinely prescribe mupirocin ointment
for use at the exit site, however newer ointments have become available. One such ointment
is Polysporin Triple. The aim of this study is to determine if catheter related infections
can be significantly reduced by the routine application of Polysporin Triple in comparison to
mupirocin ointment. A multi-centre, randomized, double blind, controlled study is proposed.
Participants will be randomized to either mupirocin or Polysporin Triple and followed for 18
months or until the first catheter related infection, death or catheter removal. The
difference in catheter related infection rates will be compared between the two groups. We
anticipate the results of this study will allow clinicians to prescribe the ointment most
likely to reduce infections. By doing so this will reduce the complication rate associated
with peritoneal dialysis and, ultimately improve survival.
Topical Antibiotics for Prevention of Intensive Care Unit (ICU) Central Line Infections [Not yet recruiting]
Use of Amnion on Partial Thickness Burns [Recruiting]
To determine if Amnion, used on partial thickness burn injuries would provide an improvement
in rate of healing, pain control and scarring as compared to standard medical treatments.
Comparison of Combination Antibiotics Eyedrop to Artificial Tear in Hordeolum After Incision and Curettage [Recruiting]
To compare the effectiveness of combined antibiotic ophthalmic solution (neomycin sulfate,
polymyxin B sulfate and gramicidin) with placebo (artificial tear) in the treatment of
hordeolum after incision and curettage
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Page last updated: 2008-03-26
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