See WARNING box.
Albuminuria, cylinduria, azotemia, and rising blood levels without any increase in dosage.
Facial flushing, dizziness progressing to ataxia, drowsiness, peripheral paresthesias (circumoral and stocking glove), apnea due to concurrent use of curariform muscle relaxants, other neurotoxic drugs or inadvertent overdosage, and signs of meningeal irritation with intrathecal administration, e.g., fever, headache, stiff neck and increased cell count and protein cerebrospinal fluid.
Other reactions occasionally reported:
Drug fever, urticarial rash, pain (severe) at intramuscular injection sites, and thrombophlebitis at intravenous injection sites.
REPORTS OF SUSPECTED POLYMYXIN B SIDE EFFECTS / ADVERSE REACTIONS
Below is a sample of reports where side effects / adverse reactions may be related to Polymyxin B. The information is not vetted and should not be considered as verified clinical evidence.
Possible Polymyxin B side effects / adverse reactions in 93 year old female
Reported by a pharmacist from United States on 2012-03-13
Patient: 93 year old female
Reactions: Cardio-Respiratory Arrest, Renal Failure, Nephropathy Toxic