Media Articles Related to Pliaglis (Lidocaine / Tetracaine Topical)
General Anesthesia May Negate Endovascular Benefit in Stroke
Source: Medscape Critical Care Headlines [2015.02.17]
Subgroup analysis of the MR CLEAN trial has shown that patients who underwent endovascular clot retrieval under general anesthesia did not show the benefit seen overall in the trial.
Medscape Medical News
The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Source: MedicineNet Heart Attack Pathology: Photo Essay Specialty [2014.12.09]
Title: The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Category: Doctor's Views
Created: 9/8/2014 12:00:00 AM
Last Editorial Review: 12/9/2014 12:00:00 AM
Parsing Out Best Practices for Endovascular Thrombectomy (CME/CE)
Source: MedPage Today Emergency Medicine [2015.02.16]
(MedPage Today) -- "Time is brain" in endovascular thrombectomy, more evidence against general anesthesia.
Published Studies Related to Pliaglis (Lidocaine / Tetracaine Topical)
Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair
removal: Phase-II and Phase-III study results. 
peel"), which air-dries and can be peeled off 30 min post-application... CONCLUSIONS: After a 30-min application, LT peel was effective and well-tolerated
Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial
access: a double-blind, randomized trial. 
non-inferior to subcutaneous local anaesthetic... CONCLUSIONS: Both the lidocaine/tetracaine patch and subcutaneous injection of
Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. [2010.11]
BACKGROUND: The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerability... CONCLUSIONS: The heated lidocaine/tetracaine patch is well tolerated, and it provides favorable depth and duration of anesthesia without significant sensory loss for superficial venous access and minor dermatological procedures after a 30-min application.
Warm lidocaine/tetracaine patch versus placebo before pediatric intravenous cannulation: a randomized controlled trial. [2008.07]
STUDY OBJECTIVE: We compare the pain of intravenous (IV) cannulation in pediatric emergency department (ED) patients after applying a topical lidocaine/tetracaine patch versus placebo. We hypothesized that application of the active patch would reduce the pain of IV cannulation by at least 15 mm... CONCLUSION: Application of a topical lidocaine/tetracaine patch resulted in a modest reduction in the pain of IV cannulation in pediatric ED patients and did not alter the rate of successful cannulations.
Randomized, double-blind, placebo-controlled study evaluating the lidocaine/tetracaine patch for induction of local anesthesia prior to minor dermatologic procedures in geriatric patients. [2005.03]
BACKGROUND: Topical anesthetics offer a noninvasive method of anesthesia. OBJECTIVE: To evaluate the efficacy and safety of the lidocaine/tetracaine patch, a 1:1 (wt:wt) eutectic mixture of lidocaine and tetracaine, for local anesthesia before minor dermatologic procedures in geriatric patients... CONCLUSION: The lidocaine/tetracaine patch is a safe and effective method for noninvasive induction of local anesthesia for minor dermatologic procedures in patients over the age of 65 years.
Clinical Trials Related to Pliaglis (Lidocaine / Tetracaine Topical)
Synera Venipuncture Pain [Not yet recruiting]
Synera, which is a heated topical patch containing both lidocaine and tetracaine, is
intended to reduce the pain associated with venipuncture and superficial dermatologic
procedures by numbing the skin. This study will test the effectiveness of the Synera
lidocaine/tetracaine patch when administered for 30 ± 5 minutes to provide dermal anesthesia
in adult oncology patients undergoing venipuncture as part of their care, for treatment or
diagnostics (laboratory or imaging). Compared to the use of the placebo patch, this study
hypothesizes that the difference of 1 cm on the 0-10 visual analogue scale (VAS) will be
observed 30 minutes after the use of the Synera patch. Pain intensity will be assessed by a
Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow [Recruiting]
The purpose of the this study is to evaluate the sfaety and efficacy of Synera(R)for
patients with lateral and medial epicondylitis and compare it to Naproxen sodius.
In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction? [Recruiting]
The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch),
used to numb the skin before IV placement, is effective in reducing pain associated with
propofol IV administration when inducing general anesthesia, compared to Gebauer's Ethyl
Chloride topical anesthetic skin refrigerant.
Study of Use of Synera for Pain During Local Skin Infiltration With Lidocaine Before Epidural Placement [Not yet recruiting]
Local infiltration with lidocaine prior to epidural placement for cesarean section, although
brief, can be painful. This pain can lead to increased anxiety and distress, adversely
affecting patient's overall experience. This study proposes to examine the application of
Synera pain patch prior to lidocaine infiltration to reduce this pain and anxiety.
The primary objective of this study is to determine the effect of the Synera on maternal
experience during epidural placement. The efficacy of Synera pain patch in reducing subject
pain during skin infiltration with lidocaine prior to epidural placement in subjects
presenting for scheduled cesarean section will be assessed.
Comparison of Synera Patch Versus LMX-4 Cream Versus Placebo Patch for Pain Reduction During Venipuncture in Children [Recruiting]
The purpose of this study is to compare the effect of Synera patch versus LMX-4 cream and
placebo on the level of pain, observed distress, difficulty of venipuncture and skin side
effects in children undergoing intravenous blood draw in the emergency setting or the