Media Articles Related to Pliaglis (Lidocaine / Tetracaine Topical)
Patients With Sleep Apnea Undergoing Joint Replacement Have Improved Outcomes With Regional Anesthesia
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.07]
Using regional anesthesia instead of general anesthesia in patients with sleep apnea undergoing total joint replacement decreases major complications by 17%, according to a study published online, ahead of print, in the journal Regional Anesthesia and Pain Medicine...
Lower Rates Of Complications In Hip And Knee Replacement Using Regional Anesthesia Technique
Source: Arthritis / Rheumatology News From Medical News Today [2013.05.03]
A highly underutilized anesthesia technique called neuraxial anesthesia, also known as spinal or epidural anesthesia, improves outcomes in patients undergoing hip or knee replacement, according to a new study by researchers at Hospital for Special Surgery...
General Anesthesia Not Linked to Raised Risk for Dementia
Source: MedicineNet Dementia Specialty [2013.05.02]
Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM
Success Rates Of Turning Breech Babies Increased By Anesthesia, Delivery Costs Reduced
Source: Pain / Anesthetics News From Medical News Today [2013.04.22]
When a baby is in the breech position at the end of pregnancy, obstetricians can sometimes turn the baby head-down to enable a safer vaginal birth. In the past, women were not given anesthesia during the turning procedure, which requires the physician to push on the woman's abdomen while monitoring the baby with ultrasound...
Development Of Wisdom Teeth In Children May Be Affected By Dental Anesthesia
Source: Dentistry News From Medical News Today [2013.04.05]
Researchers from Tufts University School of Dental Medicine have discovered a statistical association between the injection of local dental anesthesia given to children ages two to six and evidence of missing lower wisdom teeth...
Published Studies Related to Pliaglis (Lidocaine / Tetracaine Topical)
Lidocaine/tetracaine patch (Rapydan) for topical anaesthesia before arterial
access: a double-blind, randomized trial. 
non-inferior to subcutaneous local anaesthetic... CONCLUSIONS: Both the lidocaine/tetracaine patch and subcutaneous injection of
Evaluation of the depth and duration of anesthesia from heated lidocaine/tetracaine (Synera) patches compared with placebo patches applied to healthy adult volunteers. [2010.11]
BACKGROUND: The heated lidocaine/tetracaine patch (Synera; ZARS Pharma, Inc, Salt Lake City, UT) is among the local topical anesthetic formulations used to prevent procedural pain. This study was conducted to determine the depth and duration of anesthesia provided by the patch and to evaluate safety and tolerability... CONCLUSIONS: The heated lidocaine/tetracaine patch is well tolerated, and it provides favorable depth and duration of anesthesia without significant sensory loss for superficial venous access and minor dermatological procedures after a 30-min application.
Warm lidocaine/tetracaine patch versus placebo before pediatric intravenous cannulation: a randomized controlled trial. [2008.07]
STUDY OBJECTIVE: We compare the pain of intravenous (IV) cannulation in pediatric emergency department (ED) patients after applying a topical lidocaine/tetracaine patch versus placebo. We hypothesized that application of the active patch would reduce the pain of IV cannulation by at least 15 mm... CONCLUSION: Application of a topical lidocaine/tetracaine patch resulted in a modest reduction in the pain of IV cannulation in pediatric ED patients and did not alter the rate of successful cannulations.
Randomized, double-blind, placebo-controlled study evaluating the lidocaine/tetracaine patch for induction of local anesthesia prior to minor dermatologic procedures in geriatric patients. [2005.03]
BACKGROUND: Topical anesthetics offer a noninvasive method of anesthesia. OBJECTIVE: To evaluate the efficacy and safety of the lidocaine/tetracaine patch, a 1:1 (wt:wt) eutectic mixture of lidocaine and tetracaine, for local anesthesia before minor dermatologic procedures in geriatric patients... CONCLUSION: The lidocaine/tetracaine patch is a safe and effective method for noninvasive induction of local anesthesia for minor dermatologic procedures in patients over the age of 65 years.
Self-warming lidocaine/tetracaine patch effectively and safely induces local anesthesia during minor dermatologic procedures. [2005.02]
BACKGROUND: Dermatologic procedures often cause some degree of pain. A self-warming patch containing lidocaine and tetracaine (L/T) was developed to provide topical local anesthesia prior to painful procedures. OBJECTIVES: To evaluate the safety and efficacy of a self-warming L/T patch to provide anesthesia in adult patients undergoing minor dermatologic procedures... CONCLUSION: The self-warming L/T patch was effective in providing clinically useful local anesthesia for minor dermatologic procedures in adult patients.
Clinical Trials Related to Pliaglis (Lidocaine / Tetracaine Topical)
Synera Venipuncture Pain [Not yet recruiting]
Synera, which is a heated topical patch containing both lidocaine and tetracaine, is
intended to reduce the pain associated with venipuncture and superficial dermatologic
procedures by numbing the skin. This study will test the effectiveness of the Synera
lidocaine/tetracaine patch when administered for 30 ± 5 minutes to provide dermal anesthesia
in adult oncology patients undergoing venipuncture as part of their care, for treatment or
diagnostics (laboratory or imaging). Compared to the use of the placebo patch, this study
hypothesizes that the difference of 1 cm on the 0-10 visual analogue scale (VAS) will be
observed 30 minutes after the use of the Synera patch. Pain intensity will be assessed by a
Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow [Recruiting]
The purpose of the this study is to evaluate the sfaety and efficacy of Synera(R)for
patients with lateral and medial epicondylitis and compare it to Naproxen sodius.
In Children, Does Using a Synera Patch Decrease Pain When Injecting Propofol at Anesthesia Induction? [Recruiting]
The purpose of this study is to evaluate if the Synera Patch (lidocaine/tetracaine patch),
used to numb the skin before IV placement, is effective in reducing pain associated with
propofol IV administration when inducing general anesthesia, compared to Gebauer's Ethyl
Chloride topical anesthetic skin refrigerant.
Study of Use of Synera for Pain During Local Skin Infiltration With Lidocaine Before Epidural Placement [Not yet recruiting]
Local infiltration with lidocaine prior to epidural placement for cesarean section, although
brief, can be painful. This pain can lead to increased anxiety and distress, adversely
affecting patient's overall experience. This study proposes to examine the application of
Synera pain patch prior to lidocaine infiltration to reduce this pain and anxiety.
The primary objective of this study is to determine the effect of the Synera on maternal
experience during epidural placement. The efficacy of Synera pain patch in reducing subject
pain during skin infiltration with lidocaine prior to epidural placement in subjects
presenting for scheduled cesarean section will be assessed.
Comparison of Synera Patch Versus LMX-4 Cream Versus Placebo Patch for Pain Reduction During Venipuncture in Children [Recruiting]
The purpose of this study is to compare the effect of Synera patch versus LMX-4 cream and
placebo on the level of pain, observed distress, difficulty of venipuncture and skin side
effects in children undergoing intravenous blood draw in the emergency setting or the