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Pletal (Cilostazol) - Summary

 


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CONTRAINDICATION

Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. Several drugs with this pharmacologic effect have caused decreased survival compared to placebo in patients with class III-IV congestive heart failure. PLETAL is contraindicated in patients with congestive heart failure of any severity.

 

PLETAL SUMMARY

PLETAL (cilostazol) is a quinolinone derivative that inhibits cellular phosphodiesterase (more specific for phosphodiesterase III).

PLETAL is indicated for the reduction of symptoms of intermittent claudication, as indicated by an increased walking distance.


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PLETAL NEWS HIGHLIGHTS

Published Studies Related to Pletal (Cilostazol)

Inhibition of platelet aggregation by combined therapy with aspirin and cilostazol after off-pump coronary artery bypass surgery. [2008.08]

Protective Effects of Cilostazol against Transient Focal Cerebral ischemia and Chronic Cerebral Hypoperfusion Injury. [2008.06]

Long-term safety of cilostazol in patients with peripheral artery disease: the CASTLE study (Cilostazol: A Study in Long-term Effects). [2008.02]

Antiplatelet cilostazol is beneficial in diabetic and/or hypertensive ischemic stroke patients. Subgroup analysis of the cilostazol stroke prevention study. [2008]

Effects of triple antiplatelet therapy (aspirin, clopidogrel, and cilostazol) on platelet aggregation and P-selectin expression in patients undergoing coronary artery stent implantation. [2007.08.15]

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Clinical Trials Related to Pletal (Cilostazol)

Fasting Study of Cilostazol Tablets 100 mg and Pletal® Tablets 100 mg [Completed]

Safety and Efficacy of Pletal(Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud’s Phenomenon [Completed]

Safety and Efficacy of Pletal (Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaud’s Phenomenon [Completed]

Post-Marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) [Active, not recruiting]

Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness [Recruiting]

more >>

Page last updated: 2008-11-02

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