NEWS HIGHLIGHTS
Published Studies Related to Plendil (Felodipine)
Pharmacokinetics of felodipine extended-release tablets in healthy Taiwanese subjects: a retrospective review. [2011]
The objective of this study was to investigate the pharmacokinetics of felodipine (CAS 72509-76-3) in healthy male Taiwanese subjects. This is a retrospective review of five felodipine pharmacokinetic studies completed in Taiwan.Taiwanese subjects might have lower CYP3A4 activity to metabolize felodipine, which is similar to the phenomenon observed with nifedipine.
[Effect between felodipine plus irbesartan and felodipine plus metoprolol regimen on the sexual function in young and middle-aged women with hypertension]. [2010.08]
OBJECTIVE: To compare the effects between felodipine plus irbesartan and felodipine plus metoprolol regimen on blood pressure and the sexual function in young and middle-aged hypertensive women... CONCLUSION: felodipine plus irbesartan or metoprolol for 24 weeks equally reduced blood pressure and the former regimen is superior to the latter on sexual function improvement in this patient cohort.
The calcium channel blocker felodipine attenuates the positive hemodynamic effects of the beta-blocker metoprolol in severe dilated cardiomyopathy--a prospective, randomized, double-blind and placebo-controlled study with invasive hemodynamic assessment. [2009.02.20]
CONCLUSION: beta-blocker treatment in CHF patients improves left ventricular function and additionally invasive hemodynamic measurements both at rest and during exercise. In contrast, the combined therapy with the long-acting calcium antagonist felodipine neutralizes these beneficial effects of metoprolol therapy to almost placebo level, providing evidence based on hemodynamic measurements that this combination should be avoided in patients with CHF.
Comparative study of barnidipine and felodipine in Chinese patients with essential hypertension. [2006.07]
This study evaluated the efficacy and safety of barnidipine for the treatment of mild-to-moderate essential hypertension in Chinese patients. A total of 131 patients were randomized to receive either barnidipine (10 -15 mg) or felodipine (5 - 10 mg) once daily for 4 weeks...
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction. [2006.05]
BACKGROUND: Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear. OBJECTIVE: To ascertain whether furanocoumarins mediate the GFJ-felodipine interaction, a furanocoumarin-free GFJ was created and tested against orange juice and the original GFJ with respect to the oral pharmacokinetics of felodipine... CONCLUSION: Furanocoumarins are the active ingredients in GFJ responsible for enhancing the systemic exposure of felodipine and probably other CYP3A4 substrates that undergo extensive intestinal first-pass metabolism.
Clinical Trials Related to Plendil (Felodipine)
Combined Antihypertensive Therapy and Sexual Dysfunction [Recruiting]
This randomized,active controlled study aimed to compare the effects on sexual function of
treatment with combined antihypertensive drugs.
The researchers hypothesize that:
1. Both felodipine-irbesartan combination and felodipine-metoprolol combination are
effective in lowing blood pressure in patients with essential hypertension.
2. Felodipine-metoprolol combination induces a worse sexual function and a reduction of
sex hormone,whereas felodipine-irbesartan combination does not impair sexual function
and does not change hormone levels.
3. Oxidative stress decline after both combination regimens. Felodipine-irbesartan
combination has a greater impact on oxidative stress indicators than
felodipine-metoprolol combination.
Compare the Effects of Lercanidipine Hydrochloride Tablet (Zanidip�) and Felodipine Sustained-Release Tablet for Hypertension [Recruiting]
This study will be compare Felodipine sustained-release tablets, to Lercanidipine
hydrochloride tablets (Zanidip®) for the treatment of patients with mild-to-moderate primary
hypertension and to investigate the influence on patients' heart rate and blood pressure
variability.
Use of Ramipril and Felodipine Combination Therapy in Hypertension: An Effectiveness Study With Local Patients in Argentina [Completed]
China Medical University Hospital (CMUH) Triapin Listing [Recruiting]
The objective of this study is to compare the reduction in office seated systolic blood
pressure (BP) following a 8 weeks regimen of ramipril 5mg plus felodipine 5mg versus
ramipril 10mg.
To compare the response rate (defined as office systolic blood pressure (SBP) / Diastolic
blood pressure (DBP) reduce more than 10mmHg from baseline), and BP controlled rate (defined
as SBP<140mmHg and/or DBP<90mmHg) and as SBP < 130 mmHg and /or DBP < 80 mmHg in
diabetes,chronic kidney disease, known Coronary Arterial Disease (CAD) or CAD equivalent, or
10-year Framingham risk score > 10%.
To ascertain the safety and tolerability of ramipril/felodipine versus ramipril in Taiwanese
population.
To compare compliance with fixed dose combination of ramipril/felodipine versus ramipril
treatment.
Role of AT1-Receptor Blockers in Insulin-Induced Vasodilation. [Recruiting]
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the
insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II
AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2.
Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular
effects in normotensive control subjects?
Reports of Suspected Plendil (Felodipine) Side Effects
Atrial Fibrillation (5),
Drug Ineffective (4),
Drug Hypersensitivity (3),
Cerebrovascular Accident (3),
Cardiac Disorder (2),
Cerebral Haemorrhage (2),
ECG Signs of Myocardial Ischaemia (2),
Anaphylactoid Reaction (2),
Acute Coronary Syndrome (2),
Myocardial Infarction (2), more >>
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