NEWS HIGHLIGHTS
Published Studies Related to Plendil (Felodipine)
The calcium channel blocker felodipine attenuates the positive hemodynamic effects of the beta-blocker metoprolol in severe dilated cardiomyopathy--a prospective, randomized, double-blind and placebo-controlled study with invasive hemodynamic assessment. [2009.02.20]
CONCLUSION: beta-blocker treatment in CHF patients improves left ventricular function and additionally invasive hemodynamic measurements both at rest and during exercise. In contrast, the combined therapy with the long-acting calcium antagonist felodipine neutralizes these beneficial effects of metoprolol therapy to almost placebo level, providing evidence based on hemodynamic measurements that this combination should be avoided in patients with CHF.
Comparative study of barnidipine and felodipine in Chinese patients with essential hypertension. [2006.07]
This study evaluated the efficacy and safety of barnidipine for the treatment of mild-to-moderate essential hypertension in Chinese patients. A total of 131 patients were randomized to receive either barnidipine (10 -15 mg) or felodipine (5 - 10 mg) once daily for 4 weeks...
A furanocoumarin-free grapefruit juice establishes furanocoumarins as the mediators of the grapefruit juice-felodipine interaction. [2006.05]
BACKGROUND: Grapefruit juice (GFJ) enhances the systemic exposure of numerous CYP3A4 drug substrates, including felodipine, by inhibiting intestinal (but not hepatic) first-pass metabolism. Furanocoumarins have been identified as major CYP3A4 inhibitors contained in the juice, but their contribution to the GFJ effect in vivo remains unclear. OBJECTIVE: To ascertain whether furanocoumarins mediate the GFJ-felodipine interaction, a furanocoumarin-free GFJ was created and tested against orange juice and the original GFJ with respect to the oral pharmacokinetics of felodipine... CONCLUSION: Furanocoumarins are the active ingredients in GFJ responsible for enhancing the systemic exposure of felodipine and probably other CYP3A4 substrates that undergo extensive intestinal first-pass metabolism.
A factorial study of combination hypertension treatment with metoprolol succinate extended release and felodipine extended release results of the Metoprolol Succinate-Felodipine Antihypertension Combination Trial (M-FACT). [2006.04]
BACKGROUND: Many hypertensive patients require combination therapy to achieve target blood pressure (BP). beta-Blockers and dihydropyridine calcium channel blockers are effective as monotherapy in hypertensive patients and have complementary mechanisms for lowering BP... CONCLUSIONS: The antihypertensive effects of ER metoprolol succinate and ER felodipine are dose-related, and when given in combination, their BP-lowering effects are additive over a wide dose range. Low-dose combination therapy is comparable in effectiveness to high-dose monotherapy but is better tolerated.
Sympatho-excitatory responses to once-daily dihydropyridines in young versus older hypertensive patients: amlodipine versus felodipine extended release. [2006.01]
BACKGROUND: Once-daily dihydropyridines exert both indirect sympatho-excitatory and direct central sympatho-inhibitory effects. Age may affect this balance by influencing blood pressure (BP) or renin responses... CONCLUSION: We conclude that age is a major determinant not only of the BP but also of the cardiac and sympathetic responses to once-daily dihydropyridines.
Clinical Trials Related to Plendil (Felodipine)
Use of Ramipril and Felodipine Combination Therapy in Hypertension: An Effectiveness Study With Local Patients in Argentina [Completed]
China Medical University Hospital (CMUH) Triapin Listing [Recruiting]
The objective of this study is to compare the reduction in office seated systolic blood
pressure (BP) following a 8 weeks regimen of ramipril 5mg plus felodipine 5mg versus
ramipril 10mg.
To compare the response rate (defined as office systolic blood pressure (SBP) / Diastolic
blood pressure (DBP) reduce more than 10mmHg from baseline), and BP controlled rate (defined
as SBP<140mmHg and/or DBP<90mmHg) and as SBP < 130 mmHg and /or DBP < 80 mmHg in
diabetes,chronic kidney disease, known Coronary Arterial Disease (CAD) or CAD equivalent, or
10-year Framingham risk score > 10%.
To ascertain the safety and tolerability of ramipril/felodipine versus ramipril in Taiwanese
population.
To compare compliance with fixed dose combination of ramipril/felodipine versus ramipril
treatment.
Role of AT1-Receptor Blockers in Insulin-Induced Vasodilation. [Recruiting]
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the
insulin-induced microvascular dilatation. Objectives: 1. Does blockade of the angiotensin II
AT1-receptor improve the insulin-induced microvascular effects in hypertensive patients. 2.
Does blockade of the angiotensin II AT1-receptor impair the insulin-induced microvascular
effects in normotensive control subjects?
Efficacy and Safety of the Combination of Valsartan Plus Amlodipine in Hypertensive Patients Not Adequately Responding to the Combination Therapy With Ramipril Plus Felodipine [Completed]
The purpose of this study is to evaluate the efficacy of valsartan plus amlodipine in
hypertensive patients not responding to treatment with ACE inhibitor plus calcium channel
blocker
Blood Pressure and Weight Trajectory on a Dual Antihypertensive Combination Plus Sibutramine Versus Placebo in Obese Hypertensives [Completed]
To study the effect of sibutramine treatment on weight reduction and blood pressure
improvement in three groups with antihypertensive therapy whose blood pressure was not
adequately controlled with antihypertensive combination treatment.
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