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Plenaxis (Abarelix) - Drug Interactions, Contraindications, Overdosage, etc



No formal drug/drug interaction studies with Plenaxis® were performed. Cytochrome P-450 is not known to be involved in the metabolism of Plenaxis®. Plenaxis® is highly bound to plasma proteins (96 to 99%).


The maximum tolerated dose of Plenaxis® has not been determined. The maximum dose used in clinical studies was 150 mg. There have been no reports of accidental overdose with Plenaxis®.


Plenaxis® is contraindicated in those patients with a known hypersensitivity to any of the components in abarelix for injectable suspension.

Plenaxis® is not indicated in women or pediatric patients. In addition, Plenaxis® may cause fetal harm if administered to a pregnant woman.

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