This product has been prepared from large pools of human plasma. Each 100 mL of Plasma Protein Fraction (Human) 5%, USP--Plasmanate® contains 5 g selected plasma proteins buffered with sodium carbonate and stabilized with 0.004 M sodium caprylate and 0.004 M acetyltryptophan. The plasma proteins consist of approximately 88% normal human albumin, 12% alpha and beta globulins and not more than 1% gamma globulin as determined by electrophoresis.1 The concentration of these proteins is such that this solution is iso-oncotic with normal human plasma and is isotonic. The approximate concentrations of the significant electrolytes in Plasmanate are: sodium 145 mEq/L, potassium 0.25 mEq/L, and chloride 100 mEq/L. Plasmanate must be administered intravenously.
Treatment of Shock
--Plasmanate is indicated in the treatment of shock due to burns, crushing injuries, abdominal emergencies, and any other cause where there is a predominant loss of plasma fluids and not red blood cells. It is also effective in the emergency treatment of shock due to hemorrhage.3,4 Following the emergency phase of therapy, blood transfusions may be indicated depending on the severity of the blood loss.
In infants and small children, Plasmanate has been found to be very useful in the initial therapy of shock due to dehydration and infection.
Media Articles Related to Plasmanate (Plasma Protein Fraction)
ICD Shocks, Needed or Not, 'Trigger a Cascade of Procedures'
Source: theheart.org | Medscape Cardiology Headlines [2017.02.17]
"How a device is programmed should be part and parcel of quality of care," said a researcher. Done appropriately, it could help minimize the risk. "I really see this as a continuum of quality."
Heartwire from Medscape
Shocks From Implanted Defibrillators Trigger Health Costs of Their Own
Source: MedicineNet Implantable Cardiac Defibrillator Specialty [2017.02.16]
Title: Shocks From Implanted Defibrillators Trigger Health Costs of Their Own
Category: Health News
Created: 2/15/2017 12:00:00 AM
Last Editorial Review: 2/16/2017 12:00:00 AM
Shock from heart device often triggers further health care needs
Source: Cardiovascular / Cardiology News From Medical News Today [2017.02.15]
A shock from an implantable cardioverter defibrillator (ICD) may trigger an increase in health care needs for many people, regardless whether the shock was medically necessary, according to a new...
ICD Shocks Set Off Cascade of Healthcare Usage (CME/CE)
Source: MedPage Today Nephrology [2017.02.14]
(MedPage Today) -- Procedures common after appropriate and inappropriate shocks alike
'Shock and kill' strategy for curing HIV may endanger patients' brains
Source: HIV / AIDS News From Medical News Today [2016.12.07]
Combination drug treatments have become successful at long-term control of HIV infection, but the goal of totally wiping out the virus and curing patients has so far been stymied by HIV's ability...
Published Studies Related to Plasmanate (Plasma Protein Fraction)
Clinical efficacy of autologous plasma therapy for atopic dermatitis. 
protein fraction therapy (AHPT) in patients with AD in this study... CONCLUSION: This result suggests that the blood component mediating the
Some biochemical parameters of blood plasma of turkey-hens following administration of 1,2,4-triasole derivative. 
The present study involved 180 slaughter turkey-hens of heavy Big-6 type divided into four groups (in triplicate repetition for 15 birds). All the birds were fed with the same standard full-dose mixtures in 5-stage system... It was stated that tested 1,2,4-triasole derivative elevated the level of HDL fraction percentage and alkaline phosphatase activity in blood plasma.
A prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program. [1998.02]
OBJECTIVES: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome... CONCLUSION: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.
Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. [1993.09]
Around 20% of very low birthweight infants admitted to a neonatal intensive care unit become hypotensive within 24 hours of their admission...
Plasmanate as a medium supplement for in vitro fertilization. [1993.01]
CONCLUSION: Although further investigation is necessary, it appears that Plasmanate is an appropriate protein substitute in patient cases where serum is absent or unsuitable.