This product has been prepared from large pools of human plasma. Each 100 mL of Plasma Protein Fraction (Human) 5%, USP--Plasmanate® contains 5 g selected plasma proteins buffered with sodium carbonate and stabilized with 0.004 M sodium caprylate and 0.004 M acetyltryptophan. The plasma proteins consist of approximately 88% normal human albumin, 12% alpha and beta globulins and not more than 1% gamma globulin as determined by electrophoresis.1 The concentration of these proteins is such that this solution is iso-oncotic with normal human plasma and is isotonic. The approximate concentrations of the significant electrolytes in Plasmanate are: sodium 145 mEq/L, potassium 0.25 mEq/L, and chloride 100 mEq/L. Plasmanate must be administered intravenously.
Treatment of Shock
--Plasmanate is indicated in the treatment of shock due to burns, crushing injuries, abdominal emergencies, and any other cause where there is a predominant loss of plasma fluids and not red blood cells. It is also effective in the emergency treatment of shock due to hemorrhage.3,4 Following the emergency phase of therapy, blood transfusions may be indicated depending on the severity of the blood loss.
In infants and small children, Plasmanate has been found to be very useful in the initial therapy of shock due to dehydration and infection.
Media Articles Related to Plasmanate (Plasma Protein Fraction)
Septic Shock and Adequacy of Empiric Antibiotics in the ED
Source: Medscape Emergency Medicine Headlines [2014.12.08]
Does empiric antibiotic therapy in the ED provide sufficient antibiotic coverage for septic patients?
The Journal of Emergency Medicine
Toxic Shock Syndrome (TSS)
Source: MedicineNet Aches, Pain, Fever Specialty [2014.12.08]
Title: Toxic Shock Syndrome (TSS)
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Study Explains How Shock Therapy Might Ease Severe Depression
Source: MedicineNet Electroconvulsive Therapy Specialty [2012.03.20]
Title: Study Explains How Shock Therapy Might Ease Severe Depression
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Shock wave therapy for kidney stones linked to diabetes
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Mayo Clinic researchers are sounding an alert about side effects of shock wave lithotripsy such as diabetes, hypertension.
Warfarin in AF Patients on Dialysis: Worst of Both Worlds
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Samuel Goldhaber describes the shocking findings of a study of warfarin use for AF prevention in patients on hemodialysis.
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Published Studies Related to Plasmanate (Plasma Protein Fraction)
Clinical efficacy of autologous plasma therapy for atopic dermatitis. 
protein fraction therapy (AHPT) in patients with AD in this study... CONCLUSION: This result suggests that the blood component mediating the
Some biochemical parameters of blood plasma of turkey-hens following administration of 1,2,4-triasole derivative. 
The present study involved 180 slaughter turkey-hens of heavy Big-6 type divided into four groups (in triplicate repetition for 15 birds). All the birds were fed with the same standard full-dose mixtures in 5-stage system... It was stated that tested 1,2,4-triasole derivative elevated the level of HDL fraction percentage and alkaline phosphatase activity in blood plasma.
A prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program. [1998.02]
OBJECTIVES: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome... CONCLUSION: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.
Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. [1993.09]
Around 20% of very low birthweight infants admitted to a neonatal intensive care unit become hypotensive within 24 hours of their admission...
Plasmanate as a medium supplement for in vitro fertilization. [1993.01]
CONCLUSION: Although further investigation is necessary, it appears that Plasmanate is an appropriate protein substitute in patient cases where serum is absent or unsuitable.