This product has been prepared from large pools of human plasma. Each 100 mL of Plasma Protein Fraction (Human) 5%, USP--Plasmanate® contains 5 g selected plasma proteins buffered with sodium carbonate and stabilized with 0.004 M sodium caprylate and 0.004 M acetyltryptophan. The plasma proteins consist of approximately 88% normal human albumin, 12% alpha and beta globulins and not more than 1% gamma globulin as determined by electrophoresis.1 The concentration of these proteins is such that this solution is iso-oncotic with normal human plasma and is isotonic. The approximate concentrations of the significant electrolytes in Plasmanate are: sodium 145 mEq/L, potassium 0.25 mEq/L, and chloride 100 mEq/L. Plasmanate must be administered intravenously.
Treatment of Shock
--Plasmanate is indicated in the treatment of shock due to burns, crushing injuries, abdominal emergencies, and any other cause where there is a predominant loss of plasma fluids and not red blood cells. It is also effective in the emergency treatment of shock due to hemorrhage.3,4 Following the emergency phase of therapy, blood transfusions may be indicated depending on the severity of the blood loss.
In infants and small children, Plasmanate has been found to be very useful in the initial therapy of shock due to dehydration and infection.
Media Articles Related to Plasmanate (Plasma Protein Fraction)
Source: MedicineNet Appendicitis Specialty [2013.10.08]
Title: Shock (Medical)
Category: Diseases and Conditions
Created: 11/7/2007 12:00:00 AM
Last Editorial Review: 10/8/2013 12:00:00 AM
Study Explains How Shock Therapy Might Ease Severe Depression
Source: MedicineNet Electroconvulsive Therapy Specialty [2012.03.20]
Title: Study Explains How Shock Therapy Might Ease Severe Depression
Category: Health News
Created: 3/19/2012 6:06:00 PM
Last Editorial Review: 3/20/2012 12:00:00 AM
Shock wave therapy for kidney stones linked to diabetes
Source: The Doctors Lounge - Urology
Mayo Clinic researchers are sounding an alert about side effects of shock wave lithotripsy such as diabetes, hypertension.
Reserve Transfusions for Septic Patients With Lower Hb Levels
Source: Medscape Critical Care Headlines [2014.10.16]
Critically ill septic shock patients had similar outcomes whether they were transfused to hemoglobin levels of 7 g/dL or 9 g/dL, in a randomized multicenter trial from Scandinavia.
Reuters Health Information
PodMed: A Medical News Roundup From Johns Hopkins (with audio)
Source: MedPage Today OB/Gyn [2014.10.11]
(MedPage Today) -- This weeks topics include transplanting a uterus, transfusions in those with septic shock, quality of life in teens with cerebral palsy, and decision fatigue and antibiotic prescription.
Published Studies Related to Plasmanate (Plasma Protein Fraction)
Some biochemical parameters of blood plasma of turkey-hens following administration of 1,2,4-triasole derivative. 
The present study involved 180 slaughter turkey-hens of heavy Big-6 type divided into four groups (in triplicate repetition for 15 birds). All the birds were fed with the same standard full-dose mixtures in 5-stage system... It was stated that tested 1,2,4-triasole derivative elevated the level of HDL fraction percentage and alkaline phosphatase activity in blood plasma.
A prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program. [1998.02]
OBJECTIVES: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome... CONCLUSION: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.
Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. [1993.09]
Around 20% of very low birthweight infants admitted to a neonatal intensive care unit become hypotensive within 24 hours of their admission...
Plasmanate as a medium supplement for in vitro fertilization. [1993.01]
CONCLUSION: Although further investigation is necessary, it appears that Plasmanate is an appropriate protein substitute in patient cases where serum is absent or unsuitable.
Hydroxyethyl starch: an alternative to plasma for postoperative volume expansion after cardiac surgery. [1988.07]
Hydroxyethyl starch (HES) is a recently developed synthetic volume expander. Forty patients undergoing coronary artery surgery were randomized to receive either HES or plasma protein fraction (PPF) as non-blood volume replacement according to standard haemodynamic criteria...