This product has been prepared from large pools of human plasma. Each 100 mL of Plasma Protein Fraction (Human) 5%, USP--Plasmanate® contains 5 g selected plasma proteins buffered with sodium carbonate and stabilized with 0.004 M sodium caprylate and 0.004 M acetyltryptophan. The plasma proteins consist of approximately 88% normal human albumin, 12% alpha and beta globulins and not more than 1% gamma globulin as determined by electrophoresis.1 The concentration of these proteins is such that this solution is iso-oncotic with normal human plasma and is isotonic. The approximate concentrations of the significant electrolytes in Plasmanate are: sodium 145 mEq/L, potassium 0.25 mEq/L, and chloride 100 mEq/L. Plasmanate must be administered intravenously.
Treatment of Shock
--Plasmanate is indicated in the treatment of shock due to burns, crushing injuries, abdominal emergencies, and any other cause where there is a predominant loss of plasma fluids and not red blood cells. It is also effective in the emergency treatment of shock due to hemorrhage.3,4 Following the emergency phase of therapy, blood transfusions may be indicated depending on the severity of the blood loss.
In infants and small children, Plasmanate has been found to be very useful in the initial therapy of shock due to dehydration and infection.
Media Articles Related to Plasmanate (Plasma Protein Fraction)
Myocardial Injury Secondary to ICD Shocks
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Pacing and Clinical Electrophysiology
Researchers discover potential novel treatment against septic shock, one of the leading causes of mortality in intensive care unit
Source: Blood / Hematology News From Medical News Today [2014.02.10]
Septic shock is caused by excessive and systemic reaction of the entire body against infectious agents, in most cases of bacterial origin. The number of deaths by septic shock in intensive care units is very high and is still increasing, despite numerous large scale clinical trials.
Source: MedicineNet Anaphylaxis Specialty [2013.10.08]
Title: Shock (Medical)
Category: Diseases and Conditions
Created: 11/7/2007 12:00:00 AM
Last Editorial Review: 10/8/2013 12:00:00 AM
'Shocking bullying culture' at UK health regulator
Source: Litigation / Medical Malpractice News From Medical News Today [2013.07.28]
A "worrying picture" of bullying exists at the Care Quality Commission (CQC), the UK health regulator, according to a new report. Of some 236 employees at the CQC who took part in a survey, 92% reported having been subjected to bullying behaviours, adding that bullying and harassment in the workplace was "a problem.
Study Explains How Shock Therapy Might Ease Severe Depression
Source: MedicineNet Electroconvulsive Therapy Specialty [2012.03.20]
Title: Study Explains How Shock Therapy Might Ease Severe Depression
Category: Health News
Created: 3/19/2012 6:06:00 PM
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Published Studies Related to Plasmanate (Plasma Protein Fraction)
Some biochemical parameters of blood plasma of turkey-hens following administration of 1,2,4-triasole derivative. 
The present study involved 180 slaughter turkey-hens of heavy Big-6 type divided into four groups (in triplicate repetition for 15 birds). All the birds were fed with the same standard full-dose mixtures in 5-stage system... It was stated that tested 1,2,4-triasole derivative elevated the level of HDL fraction percentage and alkaline phosphatase activity in blood plasma.
A prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program. [1998.02]
OBJECTIVES: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome... CONCLUSION: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.
Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. [1993.09]
Around 20% of very low birthweight infants admitted to a neonatal intensive care unit become hypotensive within 24 hours of their admission...
Plasmanate as a medium supplement for in vitro fertilization. [1993.01]
CONCLUSION: Although further investigation is necessary, it appears that Plasmanate is an appropriate protein substitute in patient cases where serum is absent or unsuitable.
Hydroxyethyl starch: an alternative to plasma for postoperative volume expansion after cardiac surgery. [1988.07]
Hydroxyethyl starch (HES) is a recently developed synthetic volume expander. Forty patients undergoing coronary artery surgery were randomized to receive either HES or plasma protein fraction (PPF) as non-blood volume replacement according to standard haemodynamic criteria...