CLINICAL PHARMACOLOGY
Plasbumin-5 is oncotically equivalent volume for volume to normal human plasma.
When administered intravenously to an adequately hydrated subject, the oncotic (colloid osmotic) effect of Plasbumin-5 is to expand the circulating blood volume by an amount approximately equal to the volume infused. It is primarily used in the treatment of shock associated with hemorrhage, surgery, trauma, burns, bacteremia, renal failure, and cardiovascular collapse.1
Albumin is a transport protein and it may be useful in severe jaundice in hemolytic disease of the newborn.2 This could also be of importance in acute liver failure where albumin might serve the dual role of supporting plasma oncotic pressure, as well as binding excessive plasma bilirubin.1
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