Media Articles Related to Plan B One-Step (Levonorgestrel)
Ivan Today: What's the Buzz on Europe's Plan B Label Change?
Source: MedPage Today Endocrinology [2013.11.25]
(MedPage Today) -- Europeans regulators are adding information about the link between weight and the effectiveness of levonorgestrel to its label. Ivan Today is a blog by MedPage Today vice president and global editorial director Ivan Oransky, MD.
First dual-protection intravaginal ring design shows promise in long-term HIV & pregnancy prevention
Source: Clinical Trials / Drug Trials News From Medical News Today [2013.11.12]
A new intravaginal ring (IVR) has been developed for the sustained 90-day co-delivery of tenofovir and levonorgestrel, an anti-human immunodeficiency virus (HIV) drug and a contraceptive. Tenofovir is the only topical prophylactic shown to be effective at reducing the sexual transmission of HIV when formulated in a gel.
New technology combining contraception, HIV and herpes simplex virus-2 prevention
Source: HIV / AIDS News From Medical News Today [2013.11.14]
CONRAD Head of drug delivery, Meredith Clark, PhD, presented preclinical data on a new intravaginal ring that provides contraception as well as HIV-1 and HSV-2 prevention at the 2013 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in San Antonio, Texas.
Hormone levels in women using contraception affect nerve activity involved in vessel constriction
Source: Endocrinology News From Medical News Today [2013.11.10]
After menopause, women's levels of estrogen and progesterone fall. Their formerly lower risk for heart disease equals, even surpasses, men's risk. One possible contributing explanation for the change in risk is that sex hormones affect the sympathetic nervous system (SNS), which controls constriction of blood vessels and participates in the fight or flight response.
Contraception needed 3 weeks after giving birth, new mums warned
Source: Fertility News From Medical News Today [2013.10.23]
Fertility can return much more rapidly than many women assume after giving birth, and myths still abound about what contraception can and can't be used while breastfeeding.
Published Studies Related to Plan B One-Step (Levonorgestrel)
An overview of four studies of a continuous oral contraceptive (levonorgestrel 90
mcg/ethinyl estradiol 20 mcg) on premenstrual dysphoric disorder and premenstrual
and premenstrual syndrome (PMS)... CONCLUSIONS: These data, although not consistent, indicate that continuous LNG/EE
Ethinyl estradiol and levonorgestrel pharmacokinetics with a low-dose transdermal contraceptive delivery system, AG200-15: a randomized controlled trial. [2011.11.29]
BACKGROUND: This study evaluated the ethinyl estradiol (EE) and levonorgestrel (LNG) pharmacokinetic profiles of AG200-15, a transdermal contraceptive delivery system, compared with a combination oral contraceptive (COC) containing EE 35 mcg and norgestimate 250 mcg... CONCLUSIONS: EE and LNG daily exposure during AG200-15 treatment was within the range reported for a low-dose COC. The daily EE dose with AG 200-15 was equivalent to a 30-mcg COC and was safe and well tolerated. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Naproxen or estradiol for bleeding and spotting with the levonorgestrel intrauterine system: a randomized controlled trial. [2011.09.24]
OBJECTIVE: The purpose of this study was to evaluate whether oral naproxen or transdermal estradiol decreases bleeding and spotting in women who are initiating the levonorgestrel-releasing intrauterine system... CONCLUSION: The administration of naproxen resulted in a reduction in bleeding and spotting days compared with placebo. Copyright A(c) 2011 Mosby, Inc. All rights reserved.
Immediate versus delayed insertion of the levonorgestrel-releasing intrauterine device following dilation and evacuation: a randomized controlled trial. [2011.09.13]
BACKGROUND: The study was conducted to compare 6-month usage of the levonorgestrel-releasing intrauterine device (LNG-IUD) when placed immediately or 3 to 6 weeks after dilation and evacuation (D&E) procedure... CONCLUSION: Significantly more participants had the LNG-IUD placed in the immediate insertion group compared with the delayed insertion group. Given the low risk of complications, immediate post-D&E insertion of the LNG-IUD should be offered, especially for populations that may have difficulty returning for follow-up. Copyright (c) 2011 Elsevier Inc. All rights reserved.
Efficacy and safety of a levonorgestrel enteric-coated tablet as an over-the-counter drug for emergency contraception: a Phase IV clinical trial. [2011.09]
BACKGROUND: An enteric-coated levonorgestrel emergency contraceptive pill (E-LNG-ECP) is an improved formulation, in terms of side effects, which both dissolves and is absorbed in the intestine. Our aim was to evaluate the efficacy and safety of E-LNG-ECP as an over-the-counter (OTC) drug for emergency contraception (EC) in Chinese women... CONCLUSIONS: The study found that E-LNG-ECP was effective, safe and well tolerated as an OTC drug. However, an randomized controlled trial should be performed to compare standard LNG tablets with E-LNG-ECP.
Clinical Trials Related to Plan B One-Step (Levonorgestrel)
Medifast 5 & 1 Plan [Not yet recruiting]
The purpose of this study is to compare the effectiveness of the Medifast 5 & 1 Plan to a
food-based, reduced-energy diet plan. The study will be conducted over 52 weeks, including a
26-week weight-loss phase and a 26-week weight-maintenance phase. 120 participants will be
enrolled, with 60 randomized to the Medifast 5 & 1 Plan and 60 randomized to food-based,
reduced-energy diet plan. Multiple measures will be performed at baseline, 26 weeks, and 52
weeks, including anthropometry, body composition, blood pressure, blood assays, and appetite
Adaptive Radiotherapy Using Plan Selection for Bladder Cancer [Recruiting]
This protocol describes a Phase 2 clinical trial of online adaptive Radiotherapy, using a
library of 3 dose plans corresponding to Small, Medium and Large size bladder. The procedure
includes 'Common Toxicity Criteria for Adverse Effects'(CTCAE) for registration of adverse
effects (baseline, every 2'nd week during RT, 2 weeks, 3, 6, 12 and 24 month after RT) as
well as cineMR for intra-fractional motion (baseline and every week during RT). Patients
receive standard non-adaptive RT in the first week. Delineations of the bladder on the
Cone-Beam scans (CBCT) from first week of treatment are used for planning the Small and
Medium size bladder plans. Large size plan are the standard non-adaptive treatment plan used
for the first week of treatment. A margin of 5 mm for intra fractional movement is used.
Planned CORR: Planned Care for Obesity and Risk Reduction [Recruiting]
The researchers propose a randomized controlled trial to evaluate how well an intervention,
Planned Care for Obesity & Risk Reduction (Planned CORR), supports primary care treatment of
obesity in adults with at least one cardiovascular risk factor (CVRF).
Comparing Asthma Action Plans for Pediatric Asthma [Recruiting]
The purpose of this study is to evaluate and compare the relative effectiveness of two
asthma action plans (pictorial versus written) in terms of asthma action plan knowledge,
medication use, and family satisfaction with asthma education.
Radiotherapy Planning Based on Positron Emission Tomography With Fluoro-deoxyglucose For Advanced NSCLC [Recruiting]
Simultaneous radio-chemotherapy in advanced non-small cell lung cancer. The study focusses
on a randomised comparison of conventional radiotherapy planning with irradiation of
macroscopic tumor and lymph nodes together with prophylactic target volumes vs. irradiation
only of FDG-positive lesions.
Primary endpoint is the local disease control in the chest.
Reports of Suspected Plan B One-Step (Levonorgestrel) Side Effects
Menstruation Irregular (3534),
Pelvic Pain (665),
Menstruation Delayed (446),
Abdominal Pain (289),
Breast Tenderness (216), more >>