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Piroxicam (Piroxicam) - Summary


Cardiovascular Risk

  • NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (see WARNINGS).
  • Piroxicam is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).

Gastrointestinal Risk

  • NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).


10 mg and 20 mg

Piroxicam capsules contain piroxicam which is a member of the oxicam group of non-steroidal anti-inflammatory drugs (NSAIDs). Each dark green and olive capsule contains 10 mg piroxicam, each dark green capsule contains 20 mg piroxicam for oral administration.

Carefully consider the potential benefits and risks of piroxicam capsules and other treatment options before deciding to use piroxicam capsules. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).

Piroxicam capsules are indicated:

  • For relief of the signs and symptoms of osteoarthritis.
  • For relief of the signs and symptoms of rheumatoid arthritis.

See all Piroxicam indications & dosage >>


Published Studies Related to Piroxicam

Immunomodulatory effect of NSAID in geriatric patients with acute infection: effects of piroxicam on chemokine/cytokine secretion patterns and levels of heat shock proteins. A double-blind randomized controlled trial. (ISRCTN58517443). [2011.11.05]
Inflammation in older persons is associated with frailty, cachexia, and disability. We hypothesized that NSAID treatment in addition to antibiotics in older patients with acute infection might rapidly reduce inflammatory cytokines and might be of therapeutic potential to improve outcomes... Further studies are needed to establish whether these effects can change functional outcomes in geriatric patients.

Sublingual piroxicam in migraine without aura. [2011.08]
OBJECTIVE: The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura... CONCLUSIONS: The present study has demonstrated that for the acute management of migraine without aura sublingual piroxicam showed significant analgesic effect with excellent tolerability.

Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction. [2011.03]
In this study, 53 patients received piroxicam, administered orally or sublingually, after undergoing removal of symmetrically positioned lower third molars, during two separate appointments...

Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. [2011.02]
PURPOSE: We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)... CONCLUSION: A single therapy with intravenous paracetamol more efficiently relieved pain in acute renal colic than did intramuscular piroxicam. Copyright A(c) 2011 Elsevier Inc. All rights reserved.

Effects on muscle performance of NSAID treatment with piroxicam versus placebo in geriatric patients with acute infection-induced inflammation. A double blind randomized controlled trial. [2011]
cytoprotective Hsp... CONCLUSIONS: Piroxicam improves clinically relevant measures of muscle

more studies >>

Clinical Trials Related to Piroxicam

Effect of Piroxicam on Ovulation [Recruiting]
In this study the effect of piroxicam on the ovulation will be evaluated. Therefore piroxicam will be administered as a single-dose after onset of LH surge (luteinizing hormone, hormone which triggers ovulation).

Additionally blood levels of endogenous hormones (hormones produced by your body) will be measured and transvaginal ultrasound examinations will be conducted at regular intervals. In addition the concentration of piroxicam in blood will be determined in regular intervals.

With regards to the tolerability of the study drug subjects will be asked regularly how they feel.

A Double Blind, Double Dummy, Randomized, Comparative Study Of The Efficacy And Safety Of Valdecoxib 40 Mg Twice Daily, As Needed In The First Menstrual Cycle Day And Then Once A Day, And Piroxicam 40 Mg Once A Day In The Treatment Of Patients With Primary Dysmenorrhea [Completed]
To compare the analgesic efficacy, safety, and tolerability of valdecoxib versus piroxicam in subjects with moderate to severe menstrual cramping pain associated with primary dysmenorrhea.

Comparative Study of Olive Oil With Piroxicam Gel in Osteoarthritis of the Knee [Recruiting]
this is a randomized double blinded trial which is conducted to measure the efficacy of topical virgin olive oil on osteoarthritis of knee that will be done in contrast to standard piroxicam gel.

Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) [Completed]

Oral NSAI Versus Placebo as a Second Line Treatment for Renal Colics [Recruiting]
Outpatients treatment with NSAI in renal colics has not been well investigated and there is no clear recommendations regarding this matter. The aim of this study is to determine if an oral NSAI treatment is beneficial in patients discharged for the emergency departement after the first line treatment of a renal colic investigating the recurrence of pain, the reconsultation rates and the admissions.

more trials >>

Reports of Suspected Piroxicam Side Effects

Urticaria (6)Drug Interaction (5)Angioedema (5)Asthenia (5)Drug Ineffective (4)Headache (4)Renal Failure Acute (4)Blood Pressure Increased (4)Drug Hypersensitivity (4)Rash (4)more >>


Based on a total of 1 ratings/reviews, Piroxicam has an overall score of 10. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.

Piroxicam review by 50 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   osteo arthritis
Dosage & duration:   10 - 20 mg taken daily for the period of 12+ years
Other conditions:   none
Other drugs taken:   lipitor
Reported Results
Benefits:   greatly diminished arthritis pain, increased joint flexibility.
Side effects:   small nicks / scratches bled more easily
Comments:   I started taking 10mg piroxicam about 12 or 13 years ago for arthitis pain in my hands with great results. Subsequently developed arthritis in both knees and have stayed on same dosage with good relief of symptoms. Dosage was increased to 20mg after a tibial plateau fracture of a severely arthritic knee and I stayed at that dosage for about two years. Have recently lost 20+ pounds and returned to the 10mg dosage with only slight decrease in relief of discomfort.

See all Piroxicam reviews / ratings >>

Page last updated: 2013-02-10

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