- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk. (see WARNINGS).
- Piroxicam is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery (see WARNINGS).
- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events (see WARNINGS).
10 mg and 20 mg
Piroxicam capsules contain piroxicam which is a member of the oxicam group of non-steroidal anti-inflammatory drugs (NSAIDs). Each dark green and olive capsule contains 10 mg piroxicam, each dark green capsule contains 20 mg piroxicam for oral administration.
Carefully consider the potential benefits and risks of piroxicam capsules and other treatment options before deciding to use piroxicam capsules. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals (see WARNINGS).
Piroxicam capsules are indicated:
- For relief of the signs and symptoms of osteoarthritis.
- For relief of the signs and symptoms of rheumatoid arthritis.
Published Studies Related to Piroxicam
Immunomodulatory effect of NSAID in geriatric patients with acute infection: effects of piroxicam on chemokine/cytokine secretion patterns and levels of heat shock proteins. A double-blind randomized controlled trial. (ISRCTN58517443). [2011.11.05]
Inflammation in older persons is associated with frailty, cachexia, and disability. We hypothesized that NSAID treatment in addition to antibiotics in older patients with acute infection might rapidly reduce inflammatory cytokines and might be of therapeutic potential to improve outcomes... Further studies are needed to establish whether these effects can change functional outcomes in geriatric patients.
Sublingual piroxicam in migraine without aura. [2011.08]
OBJECTIVE: The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura... CONCLUSIONS: The present study has demonstrated that for the acute management of migraine without aura sublingual piroxicam showed significant analgesic effect with excellent tolerability.
Comparison of oral versus sublingual piroxicam during postoperative pain management after lower third molar extraction. [2011.03]
In this study, 53 patients received piroxicam, administered orally or sublingually, after undergoing removal of symmetrically positioned lower third molars, during two separate appointments...
Paracetamol vs piroxicam to relieve pain in renal colic. Results of a randomized controlled trial. [2011.02]
PURPOSE: We tested whether paracetamol could improve pain relief in patients visiting the emergency department with acute renal colic as compared to piroxicam, a nonsteroidal anti-inflammatory drug (NSAID)... CONCLUSION: A single therapy with intravenous paracetamol more efficiently relieved pain in acute renal colic than did intramuscular piroxicam. Copyright A(c) 2011 Elsevier Inc. All rights reserved.
Effects on muscle performance of NSAID treatment with piroxicam versus placebo in
geriatric patients with acute infection-induced inflammation. A double blind
randomized controlled trial. 
cytoprotective Hsp... CONCLUSIONS: Piroxicam improves clinically relevant measures of muscle
Clinical Trials Related to Piroxicam
Effect of Piroxicam on Ovulation [Recruiting]
In this study the effect of piroxicam on the ovulation will be evaluated. Therefore
piroxicam will be administered as a single-dose after onset of LH surge (luteinizing
hormone, hormone which triggers ovulation).
Additionally blood levels of endogenous hormones (hormones produced by your body) will be
measured and transvaginal ultrasound examinations will be conducted at regular intervals. In
addition the concentration of piroxicam in blood will be determined in regular intervals.
With regards to the tolerability of the study drug subjects will be asked regularly how they
A Double Blind, Double Dummy, Randomized, Comparative Study Of The Efficacy And Safety Of Valdecoxib 40 Mg Twice Daily, As Needed In The First Menstrual Cycle Day And Then Once A Day, And Piroxicam 40 Mg Once A Day In The Treatment Of Patients With Primary Dysmenorrhea [Completed]
To compare the analgesic efficacy, safety, and tolerability of valdecoxib versus piroxicam in
subjects with moderate to severe menstrual cramping pain associated with primary
Comparative Study of Olive Oil With Piroxicam Gel in Osteoarthritis of the Knee [Recruiting]
this is a randomized double blinded trial which is conducted to measure the efficacy of
topical virgin olive oil on osteoarthritis of knee that will be done in contrast to
standard piroxicam gel.
Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) [Completed]
Multi-Centre European Photopatch Test Study [Not yet recruiting]
It is known that people can develop an allergic skin reaction to a substance which is placed
on the skin and then subjected to sunlight. This process is called Photocontact allergic
dermatitis. It is known that people can develop Photocontact allergic dermatitis to
sunscreen chemicals (filters) and also cream forms of pain-killing drugs called nonsteroidal
anti-inflammatory drugs (NSAIDs).
The purpose of this study is to determine the frequency of Photocontact allergic dermatitis
to 19 sunscreen filters and 5 topical NSAIDs in 1,000 European patients who present to a
dermatologist with a sun-exposed site dermatitis.
Each participant will have the 24 test agents plus one control of petrolatum applied to the
skin of the back for 24 or 48 hours. After removal of the substances, the area of skin will
be exposed to a precise amount of ultraviolet-A light. The area is then assessed 24, 48 and
72 hours later to see if a photocontact allergic reaction has occured. This method is known
as photopatch testing.
The study will run for one year, during which time it is planned to recruit 1,000 patients.
Reports of Suspected Piroxicam Side Effects
Drug Interaction (5),
Drug Ineffective (4),
Renal Failure Acute (4),
Blood Pressure Increased (4),
Drug Hypersensitivity (4),
Rash (4), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Piroxicam has an overall score of 10. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Piroxicam review by 50 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || osteo arthritis|
|Dosage & duration:|| || 10 - 20 mg taken daily for the period of 12+ years|
|Other conditions:|| || none|
|Other drugs taken:|| || lipitor|
|Benefits:|| || greatly diminished arthritis pain, increased joint flexibility.|
|Side effects:|| || small nicks / scratches bled more easily|
|Comments:|| || I started taking 10mg piroxicam about 12 or 13 years ago for arthitis pain in my hands with great results. Subsequently developed arthritis in both knees and have stayed on same dosage with good relief of symptoms. Dosage was increased to 20mg after a tibial plateau fracture of a severely arthritic knee and I stayed at that dosage for about two years. Have recently lost 20+ pounds and returned to the 10mg dosage with only slight decrease in relief of discomfort.|
Page last updated: 2013-02-10