Phytonadione (Phytonadione) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Severe hypersensitivity reactions, including anaphylactoid reactions and deaths have been reported following parenteral administration. The majority of these reported events occurred following intravenous administration (see Box Warning.)

The possibility of allergic sensitivity, including an anaphylactoid reaction, should be kept in mind following parenteral administration.

Transient "flushing sensations" and "peculiar" sensations of taste have been observed, as well as rare instances of dizziness, rapid and weak pulse, profuse sweating, brief hypotension, dyspnea, and cyanosis.

Pain, swelling, and tenderness at the injection site may occur.

Infrequently, usually after repeated injection, erythematous, indurated, pruritic plaques have occurred; rarely, these have progressed to scleroderma-like lesions that have persisted for long periods. In other cases, these lesions have resembled erythema perstans.

Hyperbilirubinemia has been observed in the newborn following administration of phytonadione. This has occurred rarely and primarily with doses above those recommended. (See PRECAUTIONS, Pediatric Use.)

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO PHYTONADIONE

Possible Phytonadione side effects / adverse reactions in 54 year old male

Reported by a consumer/non-health professional from United Kingdom on 2007-01-18

Patient: 54 year old male

Reactions: Toxic Epidermal Necrolysis

Suspect drug(s):
Propofol
    Dosage: not reported

Actrapid (Insulin Human)
    Dosage: intravenous

Alfentanil
    Dosage: not reported

Amoxicillin
    Dosage: 1 gm, 3 in 1 d, intravenous

Aquasept (Triclosan)
    Dosage: not reported

Bactroban
    Dosage: not reported

Calcium Chloride
    Dosage: not reported

Calcium Gluconate
    Dosage: 10 ml, not reported

Ceftriaxone
    Dosage: 2 gm, intravenous

Enoxaparin Sodium
    Dosage: 20 mg, 1 in 1 d, subcutaneous

Dobutamine HCL
    Dosage: not reported

Fluconazole
    Dosage: 200 mg, 1 in 1 d, intravenous

Fragmin
    Dosage: 2500 iu, 1 in 1 d, not reported

Furosemide
    Dosage: 20 mg, 2 in 1 d, intravenous

Hydrocortisone
    Dosage: 100 mg, 1 in 1 d, not reported

Lactulose
    Dosage: 10 ml, not reported

Lansoprazole
    Dosage: 30 mg

Lorazepam
    Dosage: not reported

Magnesium Sulfate
    Dosage: not reported

Norepinephrine Bitartrate
    Dosage: not reported

Omeprazole
    Dosage: 40 mg, intravenous

Acetaminophen
    Dosage: not reported

Piriton (Chlorphenamine Maleate)
    Dosage: 10 mg, 4 in 1 d, intravenous

Potassium Chloride
    Dosage: not reported

Potassium Phosphates
    Dosage: not reported

Salbutamol (Salbutamol)
    Dosage: not reported, as necessary

Sando-K
    Dosage: 2 ^df^, 3 in 1 day, not reported
    Indication: Drug USE FOR Unknown Indication

Silver Sulfadiazine
    Dosage: not reported
    Indication: Drug USE FOR Unknown Indication

Simvastatin
    Dosage: 40 mg, 1 in 1d
    Indication: Drug USE FOR Unknown Indication

Sodium Bicarbonate IN Plastic Container
    Dosage: 100 mg, 1 in 1 hr, intravenous
    Indication: Drug USE FOR Unknown Indication

Sodium Chloride 0.9% (Sodium Chloride)
    Dosage: intravenous
    Indication: Drug USE FOR Unknown Indication

Thiamin Chloride TAB
    Dosage: 100 mg, 1 in 1d, oral
    Administration route: Oral
    Indication: Drug USE FOR Unknown Indication

Tinzaparin (Heparin-Fraction, Sodium Salt)
    Dosage: 3500 iu, not reported
    Indication: Drug USE FOR Unknown Indication

Phytonadione
    Dosage: not reported
    Indication: Drug USE FOR Unknown Indication

Other drugs received by patient: Aspirin; Atrovent; Ciporfloxacin (Ciprofloxacin); CO-Amoxiclav (Clavulin); Amoxicillin; Erythromycin; Metoclopramide; Midodrine Hydrochloride; Pantoprazole Sodium; Tazocin (Pip/tazo); Vancomycin; Zopiclone (Zopiclone)

Possible Phytonadione side effects / adverse reactions in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2007-01-19

Patient: 54 year old male

Reactions: Toxic Epidermal Necrolysis

Suspect drug(s):
Albuterol Sulfate
    Dosage: resp
    Indication: Pneumonia

Actrapid (Insulin Human)
    Dosage: iv

Silver Sulphadiazine
    Dosage: top
    Administration route: Topical

Lacgtulose (Lactulose)
    Dosage: 10 ml;

Lansoprazole
    Dosage: 30 mg;

Calcium Gluconate
    Dosage: 10 ml;

Ceftriaxone
    Dosage: 2 gm; iv

Omeprazole
    Dosage: 40 mg; iv

Sodium Chloride (Sodium Chloride) (0.9 Pct)
    Dosage: iv

Fragmin
    Dosage: 2500 iu;

Hydrocortisone
    Dosage: 100 mg; once;

Sando-K
    Dosage: 2 df; tid;

Simvastatin
    Dosage: 40 mg; qd;

Tinzaparin (Tinzaparin)
    Dosage: 3500 mcl;

Alfentanil

Aquasept (Triclosan)

Bactroban

Calcium Chloride (Calcium Chloride Anhydrous)

Dobutamine (Dobutamine)

Lorazepam

Magnesium Sulfate

Norepinephrine Bitartrate

Acetaminophen

Potassium Chloride

Potassium Phosphates

Propofol

Phytonadione

Amoxicillin
    Dosage: 1 gm; tid; iv

Enoxaparin Sodium
    Dosage: 20 mg; qd; sc

Fluconazole
    Dosage: 200 mg; iv

Furosemide
    Dosage: see image

Chlorpheniramine Maleate
    Dosage: 10 mg; qid; iv

Sodium Bicarbonate IN Plastic Container
    Dosage: 100 mg; iv

Thiamine Hydrochloride
    Dosage: 100 mg; qd; po
    Administration route: Oral

Other drugs received by patient: Aspirin; Atrovent; Ciprofloxacin /00697202/; Erythromycin; Metoclopramide; Midodrine; Pantoprazole Sodium; Tazocin; Vancomycin; Zopiclone; Amoxicillin; Amoxicillin + Clavulanate Potassium; CO-Codamol

Possible Phytonadione side effects / adverse reactions in 54 year old male

Reported by a individual with unspecified qualification from United Kingdom on 2007-01-30

Patient: 54 year old male

Reactions: Toxic Epidermal Necrolysis

Suspect drug(s):
Propofol
    Dosage: intravenous

Acetaminophen

Omeprazole
    Dosage: 40 mg, intravenous

Actrapid (Insulin Human)
    Dosage: intravenous

Alfentanil

Amoxicillin
    Dosage: 3 gm (1 gm, tid), intravenous

Aquasept (Triclosan)

Bactroban

Calcium Chloride (Calcium Chloride Hexahydrate)

Ceftriaxone
    Dosage: 2 gm, intravenous

Calcium Gluconate
    Dosage: 10 m1, intravenous

Enoxaparin Sodium
    Dosage: 20 mg (20 mg, qd), subcutaneous

Dobutamine (Dobutamine)

Fluconazole
    Dosage: 200 mg, (200 mg, qd), intravenous

Fragmin
    Dosage: 250 iu (250 iu, od)

Furosemide
    Dosage: 40 mg (20 mg, bid), intravenous

Hydrocortisone
    Dosage: 100 mg total

Lactulose
    Dosage: 10 mi

Lansoprazole
    Dosage: 30 mg

Lorazepam
    Dosage: 30 mg

Magnesium Sulphate (Magnseium Sulfate)

Noradrenaline (Noradrenaline)

Chlorpheniramine Maleate
    Dosage: 40 mg (10 mg, qid), intravenous

Potassium Chloride

Potassium Phosphates

Salbutamol (Salbutamol)
    Dosage: (prn)

Potassium Chloride
    Dosage: total 6df daily (tid)

Silver Sulphadiazine (Sulfadiazine Silver)
    Dosage: topical
    Administration route: Topical

Simvastatin
    Dosage: 40 mg (40 mg, qd)

Sodium Bicarbonate IN Plastic Container
    Dosage: 100 mg/hr, intravenous

Sodium Chloride 0.9%
    Dosage: 0.9 %, intravenous

Thiamin (Thiamin Hydrochloride)
    Dosage: 100 mg (qd), oral
    Administration route: Oral

Phytonadione

Tinzaparin (Heparin-Fraction, Sodium Salt)

Other drugs received by patient: Amoxicillin; Aspirin; Atorvent (Ipratropium Bromide); Ciprofloxacin; CO-Amoxiclav (Clavulin); Erythromycin; Metoclopramide; Midodrine Hydrochloride; Pantoprazole Sodium; Tazocin (Pip/tazo); Vancomycin; Zopiclone (Zopiclone)