Physostigmine Salicylate Injection is a derivative of the Calabar bean, and its active moiety, physostigmine, is also known as eserine.
Physostigmine Salicylate (physostigmine) is indicated for the following:
To reverse the effect upon the central nervous system, caused by clinical or toxic dosages of drugs capable of producing the anticholinergic syndrome.
Published Studies Related to Physostigmine
Anesthesia with 1.5 minimum alveolar concentration sevoflurane is not altered by
physostigmine as measured by bispectral and clinical indices. 
anesthesia and recovery... CONCLUSIONS: Physostigmine did not influence BIS values or early recovery when
Physostigmine for Alzheimer's disease. 
CONCLUSIONS: The evidence of effectiveness of physostigmine for the
Physostigmine and cognition in schizotypal personality disorder. 
There is evidence that reduced cholinergic activity may play a role in the
pathophysiology of cognitive impairment in the schizophrenia spectrum. We tested
the effects of physostigmine, an anticholinesterase inhibitor, on visuospatial
working memory as evaluated by the Dot test, and on verbal learning and recall as
measured by a serial learning task in patients with schizotypal personality
Physostigmine reversal of midazolam-induced electroencephalographic changes in
healthy subjects. 
electroencephalogram (EEG) by physostigmine compared to flumazenil and placebo... CONCLUSION: Physostigmine and flumazenil antagonized midazolam-induced sedation.
Extended-release physostigmine in Alzheimer disease: a multicenter, double-blind,
12-week study with dose enrichment. Physostigmine Study Group. 
mild-to-moderate Alzheimer disease (AD) in a multicenter trial... CONCLUSIONS: Physostigmine demonstrated a statistically significant benefit
Clinical Trials Related to Physostigmine
Physostigmine After General Anesthesia [Recruiting]
Recovery after general anaesthesia is often prolonged in the elderly. This group is
particularly exposed to post-operative confusion. This has negative personal consequences as
well as consequences for the postoperative care for these patients.
The hypothesis is that physostigmine will decrease the amount of time in the
post-anaesthesia care unit (PACU ), the postoperative amount of pain and shivering and
finally post-operative confusion.
The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy [Not yet recruiting]
The purpose of this study is to determine whether the administration of physostigmine in
combination with sedation for colonoscopy can minimize the cognitive decline at the time of
Pilot Study of Physostigmine-Enhanced Opioid Analgesia [Completed]
Evaluation if Physostigmine Reduces Symptoms in Patients Who Has Developed a Delirium in Intensive Care After a Surgery [Active, not recruiting]
Evaluation if physostigmine reduces symptoms in patients who has developed a delirium in
Intensive care after a surgery
Acetylcholine, Tobacco Smoking, Genes and Nicotinic Receptors [Recruiting]
The purpose of the study is to measure the sensitivity of NCFHEB binding to changes in
endogenous acetylcholine levels in healthy smoking and nonsmoking subjects, and in
schizophrenic smoking and nonsmoking subjects. We hypothesize that physostigmine-induced
elevated ACh levels will lead to a reduction in the availability of nicotinic receptors for
the binding of the radioligand. We hypothesize there will be greater increase in ACh level
(or greater reduction in radio tracer binding) in smoking as compared to nonsmoking
subjects. We hypothesize there will be greater increase in ACh level (or greater reduction
in radio tracer binding) in smoking as compared to nonsmoking subjects with schizophrenia,
but the extent of this change will be different than in controls.