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Phrenilin (Butalbital / Acetaminophen) - Summary



PHRENILIN®: Each PHRENILIN® tablet for oral administration, contains Butalbital, USP 50 mg, Acetaminophen, USP 325 mg.

PHRENILIN® tablets and PHRENILIN® FORTE capsules are indicated for the relief of the symptom complex of tension (or muscle contraction) headache.

Evidence supporting the efficacy and safety of this combination product in the treatment of multiple recurrent headaches is unavailable. Caution in this regard is required because butalbital is habitforming and potentially abusable.

See all Phrenilin indications & dosage >>


Media Articles Related to Phrenilin (Butalbital / Acetaminophen)

ANA: Brain Features Tied to Personality in Chronic Daily Headache (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2016.10.22]
(MedPage Today) -- Is personality a modifiable risk factor for CDH?

ANA: Headache Neuroimaging Reduces Time to Glioma Diagnosis (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2016.10.21]
(MedPage Today) -- Effect remains modest, however, large database review shows

ANA: Headaches Found Common in HIV+ People in Rural Uganda (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2016.10.21]
(MedPage Today) -- Call for better treatment to improve quality of life

ANA: Sympathetic Dysfunction May Be Culprit in Post-Traumatic Headache (CME/CE)
Source: MedPage Today Neurology [2016.10.20]
(MedPage Today) -- Pupillary dysfunction observed in small trial, needs expansion into wider autonomic testing

Patients OK With Placebo in Some Cluster Headache Trials (CME/CE)
Source: MedPage Today Psychiatry [2016.10.18]
(MedPage Today) -- But they wouldn't enroll in preventive surgical device or abortive treatment trials

more news >>

Published Studies Related to Phrenilin (Butalbital / Acetaminophen)

Sumatriptan-Naproxen and Butalbital: A Double-Blind, Placebo-Controlled Crossover Study. [2011.11.21]
Objectives.- The primary objective was to compare the efficacy of a sumatriptan and naproxen combination medication (SumaRT/Nap-85 mg sumatriptan and 500 mg naproxen sodium), a butalbital-containing combination medication (BCM-50 mg butalbital, 325 mg acetaminophen, 40 mg caffeine), and placebo when used to treat moderate to severe migraine headache pain in subjects who used BCMs in the past.

Butalbital in the treatment of headache: history, pharmacology, and efficacy. [2001.11]
Analgesics containing butalbital compounded with aspirin, acetaminophen, and/or caffeine are widely used for the treatment of migraine and tension-type headache. The butalbital-containing compounds are efficacious in placebo-controlled trials among patients with episodic tension-type headaches.Because of concerns about overuse, medication-overuse headache, and withdrawal, their use should be limited and carefully monitored.

more studies >>

Page last updated: 2016-10-22

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