NEWS HIGHLIGHTS
Published Studies Related to Photofrin (Porfimer)
ALA and Photofrin(R) Fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial. [2008.10]
Glioblastoma multiforme (GBM) carries dismal prognosis and cannot be eradicated surgically because of its wide brain invasion. The objective of this prospective randomised controlled trial was to evaluate ALA and Photofrin(R) fluorescence-guided resection (FGR) and repetitive photodynamic therapy (PDT) in GBM...
ALA and Photofrin(R) Fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial. [2007.10.10]
Glioblastoma multiforme (GBM) carries dismal prognosis and cannot be eradicated surgically because of its wide brain invasion. The objective of this prospective randomised controlled trial was to evaluate ALA and Photofrin(R) fluorescence-guided resection (FGR) and repetitive photodynamic therapy (PDT) in GBM...
Photodynamic therapy with porfimer sodium for ablation of high-grade dysplasia in Barrett's esophagus: international, partially blinded, randomized phase III trial. [2005.10]
BACKGROUND: Barrett's esophagus (BE) may lead to high-grade dysplasia (HGD) and adenocarcinoma. The objective was to examine the impact of treating patients with BE and with HGD by using porfimer sodium (POR) and photodynamic therapy (PDT) for ablating HGD and reducing the incidence of esophageal adenocarcinoma... CONCLUSIONS: PORPDT in conjunction with omeprazole is an effective therapy for ablating HGD in patients with BE and in reducing the incidence of esophageal adenocarcinoma.
A multispectral fluorescence imaging system: design and initial clinical tests in intra-operative Photofrin-photodynamic therapy of brain tumors. [2003]
BACKGROUND AND OBJECTIVES: Intra-operative identification of tumor by fluorescence may improve surgical resection or photodynamic therapy (PDT). A novel instrument was designed, constructed, and tested for this purpose... CONCLUSIONS: The system performed to specification under realistic operating conditions and could reveal unresected residual tumor tissue. It may be used for either PDT dosimetry/monitoring and/or for surgical guidance. Copyright 2003 Wiley-Liss, Inc.
Photodynamic therapy with porfimer sodium versus thermal ablation therapy with Nd:YAG laser for palliation of esophageal cancer: a multicenter randomized trial. [1995.12]
BACKGROUND: Photodynamic therapy (PDT) is a different type of laser treatment from Nd:YAG thermal ablation for palliation of dysphagia from esophageal cancer... CONCLUSIONS: Photodynamic therapy with porfimer sodium has overall equal efficacy to Nd:YAG laser thermal ablation for palliation of dysphagia in esophageal cancer, and equal or better objective tumor response rate. Temporary photosensitivity is a limitation, but PDT is carried out with greater ease and is associated with fewer acute perforations than Nd:YAG laser therapy.
Clinical Trials Related to Photofrin (Porfimer)
Photodynamic Therapy Using Porfimer Sodium in Treating Patients Who Are Undergoing Surgery for Recurrent Malignant Astrocytoma [Active, not recruiting]
RATIONALE: Photodynamic therapy uses a drug, such as porfimer sodium, that becomes active
when it is exposed to a certain kind of light. When the drug is active, tumor cells are
killed. Giving photodynamic therapy after surgery may kill any remaining tumor cells.
PURPOSE: This randomized clinical trial is studying two different light doses of photodynamic
therapy using porfimer sodium to compare how well they work in treating patients who are
undergoing surgery for recurrent malignant astrocytoma.
Sequential Whole Bladder Photodynamic Therapy (WBPDT) in the Management of Superficial Bladder Cancer [Recruiting]
This protocol is evaluating efficacy and toxicity of three sequential whole bladder
photodynamic treatment with Photofrin and red laser light (630 nm) in the management of
superficial bladder cancer (non-muscle invasive) in those patients who have failed or are
not candidates for conventional intravesical therapy.
Stent Placement With or Without Photodynamic Therapy Using Porfimer Sodium as Palliative Treatment in Treating Patients With Stage III or Stage IV Cholangiocarcinoma That Cannot Be Removed By Surgery [Withdrawn]
RATIONALE: Stent placement may help reduce symptoms caused by the tumor. Photodynamic therapy
uses a drug, such as porfimer sodium, that becomes active when it is exposed to a certain
kind of light. When the drug is active, tumor cells are killed. This may be an effective
treatment for cholangiocarcinoma. It is not yet known whether stent placement and
photodynamic therapy using porfimer sodium are more effective than stent placement alone in
treating cholangiocarcinoma.
PURPOSE: This randomized phase III trial is studying stent placement and photodynamic therapy
using porfimer sodium to see how well they work compared to stent placement alone as
palliative treatment in treating patients with stage III or stage IV cholangiocarcinoma that
cannot be removed by surgery.
Photodynamic Therapy With Porfimer Sodium in Treating Patients With Precancerous Lesions, Cancer, or Other Disease of the Aerodigestive Tract [Recruiting]
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a
certain kind of light. When the drug is active, precancerous cells and cancer cells are
killed.
PURPOSE: This phase II trial is studying the side effects and how well photodynamic therapy
with porfimer sodium works in treating patients with precancerous lesions, cancer, or other
disease of the aerodigestive tract.
Porfimer Sodium in Diagnosing Patients With Head and Neck Cancer [Completed]
RATIONALE: Drugs that make cancer cells more visible to light may help in the diagnosis of
head and neck cancer.
PURPOSE: Phase II trial to study the usefulness of porfimer sodium in diagnosing patients
with head and neck cancer.
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