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Phospholine Iodide (Echothiophate Iodide Ophthalmic) - Summary

 

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BOX WARNING

DIRECTIONS FOR PREPARING EYEDROPS

1. Use aseptic technique.

2. Tear off aluminum seals, and remove and discard rubber plugs from both drug and diluent containers.

3. Pour diluent into drug container.

4. Remove dropper assembly from its sterile wrapping. Holding dropper assembly by the screw cap and, WITHOUT COMPRESSING RUBBER BULB, insert into drug container and screw down tightly.

5. Shake for several seconds to ensure mixing.

6. Do not cover nor obliterate instructions to patient regarding storage of eyedrops.

 

SUMMARY

Phospholine Iodide®
(echothiophate iodide for ophthalmic solution)

Phospholine Iodide® is echothiophate iodide for ophthalmic solution. Chemical name: (2-mercaptoethyl) trimethylammonium iodide O,O-diethyl phosphorothioate. Echothiophate iodide for ophthalmic solution occurs as a white, crystalline, water-soluble, hygroscopic solid having a slight mercaptan-like odor. When freeze-dried in the presence of potassium acetate, the mixture appears as a white amorphous deposit on the walls of the bottle.

Each package contains materials for dispensing 5 mL of eyedrops: (1) bottle containing sterile echothiophate iodide for ophthalmic solution in one of four potencies [1.5 mg (0.03%), 3 mg (0.06%), 6.25 mg (0.125%), or 12.5 mg (0.25%)] as indicated on the label, with 40 mg potassium acetate in each case. Sodium hydroxide or acetic acid may have been incorporated to adjust pH during manufacturing. (2) a 5 mL bottle of sterile diluent containing chlorobutanol (chloral derivative), 0.55%; mannitol, 1.2%; boric acid, 0.06%; and sodium phosphate, 0.026%. (3) sterilized dropper.

Phospholine Iodide® is indicated for the following:

Glaucoma

Chronic open-angle glaucoma. Subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated. Certain non-uveitic secondary types of glaucoma, especially glaucoma following cataract surgery.

Accommodative Esotropia

Concomitant esotropias with a significant accommodative component.

NEWS HIGHLIGHTS RELATED TO PHOSPHOLINE IODIDE

Published Studies Related to Phospholine Iodide (Echothiophate Iodide Ophthalmic)

H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys. [2004.08]

Echothiophate iodide induced transient hyper- and hypothyroidism. [1996.06]

Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops. [1995]

Electroconvulsive therapy and the chronic use of pseudocholinesterase-inhibitor (echothiophate iodide) eye drops for glaucoma. A case report. [1992.01]

Intraocular pressure response to the replacement of pilocarpine or carbachol with echothiophate. [1991]

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Page last updated: 2007-05-02

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