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Phospholine Iodide (Echothiophate Iodide Ophthalmic) - Summary




1. Use aseptic technique.

2. Tear off aluminum seals, and remove and discard rubber plugs from both drug and diluent containers.

3. Pour diluent into drug container.

4. Remove dropper assembly from its sterile wrapping. Holding dropper assembly by the screw cap and, WITHOUT COMPRESSING RUBBER BULB, insert into drug container and screw down tightly.

5. Shake for several seconds to ensure mixing.

6. Do not cover nor obliterate instructions to patient regarding storage of eyedrops.



Phospholine Iodide is echothiophate iodide for ophthalmic solution. Chemical name: (2-mercaptoethyl) trimethylammonium iodide O,O-diethyl phosphorothioate. Echothiophate iodide for ophthalmic solution occurs as a white, crystalline, water-soluble, hygroscopic solid having a slight mercaptan-like odor. When freeze-dried in the presence of potassium acetate, the mixture appears as a white amorphous deposit on the walls of the bottle.

Each package contains materials for dispensing 5 mL of eyedrops: (1) bottle containing sterile echothiophate iodide for ophthalmic solution in one of four potencies [1.5 mg (0.03%), 3 mg (0.06%), 6.25 mg (0.125%), or 12.5 mg (0.25%)] as indicated on the label, with 40 mg potassium acetate in each case. Sodium hydroxide or acetic acid may have been incorporated to adjust pH during manufacturing. (2) a 5 mL bottle of sterile diluent containing chlorobutanol (chloral derivative), 0.55%; mannitol, 1.2%; boric acid, 0.06%; and sodium phosphate, 0.026%. (3) sterilized dropper.

Phospholine Iodide is indicated for the following:


Chronic open-angle glaucoma. Subacute or chronic angle-closure glaucoma after iridectomy or where surgery is refused or contraindicated. Certain non-uveitic secondary types of glaucoma, especially glaucoma following cataract surgery.

Accommodative Esotropia

Concomitant esotropias with a significant accommodative component.

See all Phospholine Iodide indications & dosage >>


Published Studies Related to Phospholine Iodide (Echothiophate Iodide Ophthalmic)

Lowering of IOP by echothiophate iodide in pseudophakic eyes with glaucoma. [2010.08]
PURPOSE: We retrospectively investigated the intraocular pressure (IOP)-lowering effects of echothiophate iodide (EI) as adjunctive treatment for pseudophakic glaucoma patients who were receiving maximal medical therapy (MMT), including the newer class of medications, i.e., prostaglandin analogs, alpha-2 agonists, and topical carbonic anhydrase inhibitors... CONCLUSION: EI substantially decreased the IOPs in pseudophakic glaucoma eyes receiving maximal medical therapy, including the newer class of medications. This drug may be the last resort for post-cataract advanced glaucoma patients and may obviate the need for filtering surgery among the very elderly.

H-7 effect on outflow facility after trabecular obstruction following long-term echothiophate treatment in monkeys. [2004.08]
PURPOSE: To determine whether H-7 can enhance outflow facility after trabecular meshwork obstruction by extracellular material that accumulates after long-term treatment of monkeys with the cholinesterase inhibitor echothiophate iodide (ECHO)... CONCLUSIONS: H-7 can enhance OF in the presence of trabecular obstruction produced by long-term ECHO treatment. This suggests that H-7 may be useful in treating glaucoma, even in the presence of accumulated plaque material that has been described previously.

Echothiophate iodide induced transient hyper- and hypothyroidism. [1996.06]
A case of hyper- and hypothyroidism induced by echothiophate iodide eye drops is presented. The thyroid dysfunction was due to excessive iodide intake from the eye drops..

Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops. [1995]
A patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levels were severely depressed and symptoms resolved spontaneously following discontinuation of the eye drops..

Electroconvulsive therapy and the chronic use of pseudocholinesterase-inhibitor (echothiophate iodide) eye drops for glaucoma. A case report. [1992.01]
A case is presented in which a patient who required treatment with electroconvulsive therapy had a history of being treated with pseudocholinesterase-inhibitor eye drops (echothiophate iodide) for glaucoma. As treatment with this antiglaucoma agent contraindicated the use of succinylcholine for a minimum of 10-14 days, the short-acting nondepolarizing agent atracurium was employed instead.

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Reports of Suspected Phospholine Iodide (Echothiophate Iodide Ophthalmic) Side Effects

Visual Acuity Reduced (9)Headache (4)Reading Disorder (4)Hearing Impaired (4)Visual Impairment (4)Vision Blurred (3)Hypersensitivity (2)Nasopharyngitis (2)Eye Irritation (2)Eye Pruritus (2)more >>

Page last updated: 2011-12-09

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