PHISOHEX SUMMARY
pHisoHex®
hexachlorophene detergent cleanser
pHisoHex, brand of hexachlorophene detergent cleanser, is an antibacterial sudsing emulsion for topical administration. pHisoHex contains a colloidal dispersion of hexachlorophene 3% (w/w) in a stable emulsion consisting of entsufon sodium, petrolatum, lanolin cholesterols, methylcellulose, polyethylene glycol, polyethylene glycol monostearate, lauryl myristyl diethanolamide, sodium benzoate, and water. pH is adjusted with hydrochloric acid. Entsufon sodium is a synthetic detergent.
pHisoHex is indicated for use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful. Use only as long as necessary for infection control.
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NEWS HIGHLIGHTS
Clinical Trials Related to Phisohex (Hexachlorophene Topical)
Assessment of Drug-Eluting Ureteral Stent on Bacterial Adherence and Biofilm Formation [Recruiting]
The purpose of this study is to determine the clinical effects of a triclosan stent on
adherent bacteria, stent biofilms, and patient urine cultures in patients with an indwelling
triclosan ureteral stent. The patient populations that will be tested include: patients
following ureteroscopy, patients who require chronic long-term stenting, and patients
scheduled to undergo shockwave lithotripsy who require a ureteral stent. It is hypothesized
that triclosan eluting ureteral stents will reduce the number of bacteria both on (within
biofilm) and around (in the urine) a ureteral stent.
Prospective Study of Methicillin-Resistant Staphylococcus Aureus (MRSA) Among HIV-Infected Persons [Recruiting]
This study will prospectively evaluate the prevalence and incidence (over a two year period)
of MRSA colonization and infection among HIV-infected military beneficiaries to determine
predictors for the development of MRSA colonization and infection. This study will also
investigate the utility of decolonization procedures for clearance of MRSA carriage and
prevention of MRSA infections. Finally, the molecular characteristics and the antimicrobial
sensitivities of isolates in this population will be determined.
The Efficacy of a Toothpaste to Reduce Sensitivity [Recruiting]
Community-Acquired Methicillin Resistant Staphylococcus Aureus Colonization in Pregnant Women and Infections in Newborns [Recruiting]
Background:
Community acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging
pathogen of the 21st century whose incidence as a cause of local and invasive infections has
significantly increased, especially in previously healthy term and near term newborns. The
etiology of the increasing incidence of infection in previously healthy term and near-term
newborns remains unclear.
Hypothesis:
1. The incidence of previously healthy newborns infected with CA-MRSA skin & soft tissue
(SSTI) and invasive infections is higher in those born to mothers colonized with
CA-MRSA.
2. Pregnant women colonized with CA-MRSA are at higher risk for post-partum infection with
this organism.
Specific Aims:
1. To determine the incidence of nasal and vaginal colonization with CA-MRSA in pregnant
women and determine the genetic similarities of these strains.
2. To study CA-MRSA transmission dynamics and evaluate the incidence of SSTI and invasive
infections in newborns born to S. aureus colonized mothers.
3. To study the efficacy of attempted decolonization in CA-MRSA colonized mothers in
decreasing the incidence of transmission and development of SSTI and invasive
infections in their infants during the first month of life.
Potential Impact:
Understanding the epidemiology of the transmission dynamics of CA-MRSA in previously healthy
newborns will provide important information to support the development of strategies aimed
at the interruption of transmission and prevention of infection caused by CA-MRSA in
newborns, as well as in pregnant women. This will also allow for the development of
infection control strategies to prevent the spread of this organism among post-partum units
and nurseries.
Feasibility Study of the Effect of Intra-Dermal Insulin Injection on Blood Glucose Levels After Eating [Recruiting]
This study is to determine the effect of intra-dermal (ID) administration of regular and of
rapid-acting insulin, before eating, on blood glucose levels for several hours after a
standard meal (a mixed, liquid meal). Insulin will also be given normally, subcutaneously,
for control or comparison purposes. The hypothesis or expectation is that ID insulin will
work more quickly and control blood glucose levels better than SC injection.
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