Phenytoin (Phenytoin Sodium) - Summary

PHENYTOIN SUMMARY

PHENYTOIN SODIUM
INJECTION, USP

Phenytoin Sodium Injection, USP is a sterile, nonpyrogenic solution of phenytoin sodium and water for injection. Each milliliter (mL) contains phenytoin sodium 50 mg, propylene glycol 40% and alcohol 10%. Headspace nitrogen gassed. Also contains sodium hydroxide for pH adjustment; pH is 11.9 (10.0 to 12.3). The solution contains no bacteriostat, antimicrobial agent or added buffer. Single-dose, discard unused portion. NOTE: Do not use Injection if it is hazy or contains a precipitate.

Phenytoin Sodium Injection is indicated for the control of status epilepticus of the grand mal type, and prevention and treatment of seizures occurring during neurosurgery.

PHENYTOIN NEWS HIGHLIGHTS

Published Studies Related to Phenytoin

Ineffectiveness of folic acid supplementation against phenytoin-induced decrease in salivary immunoglobulin A concentration of epileptic patients. [2008]

Topical phenytoin solution for treating pressure ulcers: a prospective, randomized, double-blind clinical trial. [2007.11]

Phenytoin as an augmentation for SSRI failures: a small controlled study. [2006.11]

Sodium valproate vs phenytoin in status epilepticus: a pilot study. [2006.07.25]

Safety and efficacy of clobazam versus phenytoin-sodium in the antiepileptic drug treatment of solitary cysticercus granulomas. [2006.06]

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Clinical Trials Related to Phenytoin

Steady-State Study of Extended Phenytoin Sodium Capsules 100 mg and Dilantin® Kapseals® 100 mg [Completed]

Phenytoin as an Augmentation for SSRI Failures [Completed]

An Open-Label Interaction Study to Look at the Effects of Brivaracetam on Phenytoin When Taken Together in 15 Adult Patients With Epilepsy. [Completed]

Dilantin Levels With Continuous Delivery of Enteral Feedings - A Pilot Study [Terminated]

Study of Efficacy of Phenytoin in Therapy of Children With Bronchial Asthma [Completed]

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