Phenergan (Promethazine Hydrochloride) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Central Nervous System

Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.

Cardiovascular –Increased or decreased blood pressure, tachycardia, bradycardia, faintness.

Dermatologic –Dermatitis, photosensitivity, urticaria.

Hematologic –Leukopenia, thrombocytopenia, thrombocytopenic purpura, agranulocytosis.

Gastrointestinal –Dry mouth, nausea, vomiting, jaundice.

Respiratory –Asthma, nasal stuffiness, respiratory depression (potentially fatal) and apnea (potentially fatal). (See WARNINGS-Respiratory Depression.)

Other –Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported. (See WARNINGS-Neuroleptic Malignant Syndrome.)

Paradoxical Reactions

Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO PHENERGAN

Possible Phenergan side effects / adverse reactions in 35 year old male

Reported by a individual with unspecified qualification from United States on 2007-01-11

Patient: 35 year old male weighing 70.3 kg (154.7 pounds)

Reactions: Wrong Technique in Drug Usage Process, Thrombophlebitis Superficial, Impaired Work Ability, Injection Site Pain, Injection Site Irritation

Suspect drug(s):
Phenergan

Possible Phenergan side effects / adverse reactions in 75 year old female

Reported by a individual with unspecified qualification from United States on 2007-01-16

Patient: 75 year old female weighing 49.9 kg (109.8 pounds)

Reactions: Speech Disorder, Aphasia

Suspect drug(s):
Phenergan
    Dosage: injection one
    Indication: Nausea

Phenergan
    Dosage: injection one
    Indication: Vomiting

Possible Phenergan side effects / adverse reactions in 29 year old male

Reported by a individual with unspecified qualification from Hong Kong on 2007-04-20

Patient: 29 year old male

Reactions: Agitation, Confusional State, Serotonin Syndrome, Abdominal Pain Upper, Electrocardiogram QRS Complex Prolonged, White Blood Cell Count Increased, Blood Glucose Increased, Hypertonia, Blood Pressure Increased, Vomiting, Metabolic Acidosis, Electrocardiogram QT Corrected Interval Prolonged, Hyponatraemia, Muscle Twitching, Myoclonus, Renal Impairment, Diarrhoea, Heart Rate Increased, NO Therapeutic Response, Nuclear Magnetic Resonance Imaging Abnormal, QRS Axis Abnormal

Suspect drug(s):
Dextromethorphan Hydrobromide
    Indication: Influenza Like Illness

Hyoscine HBR HYT
    Dosage: intramuscular

Hyoscine HBR HYT

Metoclopramide
    Dosage: 10 mg, intravenous

Morphine Sulfate
    Dosage: 2 mg, intravenous

Motilium

Mylanta/aus/(aluminium Hydroxide Gel, Dried, Magnesium Hydroxide, Sime
    Dosage: oral
    Administration route: Oral

Paracetamol (Nch) (Acetaminophen (Paracetamol))

Phenergan

Senokot

SLO-BID

Tramadol HCL
    Dosage: 100 mg , intramuscular
    Indication: Abdominal Pain Upper