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Permapen (Penicillin G Benzathine) - Drug Interactions, Contraindications, Overdosage, etc



Carcinogenesis, Mutagenesis, Impairment of Fertility

No information or long term studies are available on the carcinogenesis, mutagenesis, or impairment of fertility with the use of penicillins.


Pregnancy Category B – Teratogenic Effects

Reproduction studies in the mouse, rat and rabbit have revealed no evidence of impaired fertility or harm to the fetus due to penicillin G. Human experience with the penicillins during pregnancy has not shown any positive evidence of adverse effects on the fetus. There are, however, no adequate and well controlled studies in pregnant women showing conclusively that harmful effects of these drugs on the fetus can be excluded. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.


Penicillin in overdosage has the potential to cause neuromuscular hyperirritability. In case of overdosage discontinue medication, treat symptomatically, and institute supportive measures as required.

Penicillin G is hemodialyzable.


A history of a previous hypersensitivity reaction to any penicillin is a contraindication.

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