(Penicillin G Benzathine)
For lntramuscular Use Only
Permapen® (Penicillin G Benzathine) Injectable Suspension, a sterile antibacterial agent, is a repository penicillin compound which provides blood levels for long periods following its intramuscular injection. This property is the result of its extremely low solubility in water. Each milliliter contains 600,000 units of penicillin G benzathine; 0.006 grams sodium citrate; 0.003 grams polyvinylpyrrolidone; 0.010 grams lecithin, and 0.003 grams sodium carboxymethylcellulose in an aqueous suspension. Permapen also contains methylparaben 0.09% and propylparaben 0.01% as preservatives.
Intramuscular penicillin G benzathine is indicated in the treatment of infections in both children and adults due to penicillin G-susceptible microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form in the indications listed below. Therapy should be guided by clinical response.
Note: When high sustained serum levels are required, injectable penicillin G either IM or IV should be used.
The following infections will usually respond to adequate dosages of intramuscular penicillin G benzathine:
Upper Respiratory Tract (pharyngitis): streptococci (group A – without bacteremia).
Venereal Infections: Syphilis
Yaws, bejel, and pinta.
Medical Conditions in Which Penicillin G Benzathine Therapy is Indicated As Prophylaxis
Rheumatic fever and/or chorea: Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. It has also been used as follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.
Media Articles Related to Permapen (Penicillin)
Plant MIR2911 - 'Virological penicillin' directly targets influenza A viruses
Source: Bird Flu / Avian Flu News From Medical News Today [2014.10.08]
In a new study, Chen-Yu Zhang's group at Nanjing University present an extremely novel finding that a plant microRNA, MIR2911, which is enriched in honeysuckle, directly targets influenza A viruses...
Published Studies Related to Permapen (Penicillin)
Penicillin to prevent recurrent leg cellulitis. 
the prevention of recurrent cellulitis... CONCLUSIONS: In patients with recurrent cellulitis of the leg, penicillin was
Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. [2011.06]
BACKGROUND: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A beta -hemolytic streptococcal (GAS) pharyngitis... CONCLUSION: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.
Administration of perioperative penicillin reduces postoperative serum amyloid a response in horses being castrated standing. [2010.07]
OBJECTIVES: To compare postoperative inflammatory responses in horses administered perioperative procaine penicillin and those not administered penicillin using acute phase protein serum amyloid A (SAA) as a marker of inflammation. STUDY DESIGN: Randomized clinical trial. ANIMALS: Stallions (n=50) castrated under field conditions... CONCLUSIONS: Perioperative antimicrobial therapy reduced the postoperative SAA response, suggesting that bacteria were present in the surgical wound and contributed to inflammation after castration. Horses with elevated preoperative SAA concentrations developed infectious complications more often than horses with normal preoperative SAA concentrations. CLINICAL RELEVANCE: Administration of antimicrobials may be important in horses being castrated standing under field conditions. Increased SAA concentrations seem to be an indicator of increased surgical risk in horses and may be useful before elective surgery for planning.
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. [2010.06.01]
BACKGROUND: Syphilis remains an important source of morbidity worldwide. Long-acting penicillin is the only therapy currently recommended for syphilis in much of the world. Because of hesitation to use penicillin for fear of anaphylaxis, there is a need for an effective, well-tolerated alternative to penicillin for syphilis therapy... CONCLUSIONS: In this trial, the efficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine penicillin G for the treatment of early syphilis in persons without HIV infection.
Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. [2010.05]
AIM: We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS)... CONCLUSIONS: AMP and PEN combined with gentamicin have similar effectiveness in the empiric treatment of suspected neonatal EOS.
Clinical Trials Related to Permapen (Penicillin)
Bicillin L-A vs Placebo for the Treatment of Chronic, Plaque-Type Psoriasis Unresponsive to Topical Medications [Recruiting]
The purpose of this study is to determine the efficacy for Bicillin L-A, administered
intramuscularly in a dose of 2. 4 million units every three (3) weeks, for the treatment of
chronic, plaque-type psoriasis unresponsive to topical medications or when other systemic
therapies are contraindicated.
Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia [Recruiting]
This study seeks to determine whether clinical outcome following initial treatment of severe
pneumonia with oral amoxicillin is as effective as the current standard benzyl penicillin.
The study will also provide an estimate of the proportion of Kenyan children with severe
pneumonia who fail treatment with a single antibiotic.
Simplified Antibiotic Therapy for Sepsis in Young Infants [Recruiting]
This trial evaluates primary care clinic-based simplified antibiotic therapy options for
young infants, 0-59 days old in high neonatal mortality settings in peri-urban Karachi where
hospital referral is frequently refused by families.
A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals [Completed]
To provide information on the response of HIV infected, neurosyphilis patients to the
currently recommended treatment for neurosyphilis; to determine whether possible co-infection
with both HIV and syphilis makes more difficult the diagnosis of syphilis; to explore the
usefulness of an alternative treatment which, if effective, would permit outpatient treatment
for neurosyphilis that until now required prolonged hospitalization.
Studies suggest that syphilis treatment failures may be more common in HIV infected patients
than in patients without HIV infection and that treatment failures occur due to and/or are
displayed as central nervous system (CNS) involvement. Very little is known about the best
treatment course for neurosyphilis in patients who are also infected with HIV.
Azithromycin/Bicillin Syphilis [Active, not recruiting]
The purpose of this study is to determine if Azithromycin, a drug approved for treatment of
other infections, is as affective for syphilis therapy is as the usual treatment.
Approximately 600 healthy adults, who are HIV-negative, age 18 to 55 years of age with
primary, secondary or early latent syphilis, will be participating in this research study.
Volunteers will be enrolled in 4 cities of the United States and in Madagascar. Participants
will be chosen randomly (by chance) to receive one of 2 study drugs: Benzathine Penicillin
given as one dose (2 shots in the buttocks) or 4 tablets of Azithromycin. Over 2 years, 10
visits are required. Procedures will include blood samples, physical exam, and swabs of
sores. For subjects who report history of Penicillin allergy will be given either 2. 0 g of
oral Azithromycin or 100 mg Doxycycline taken orally, twice a day for 14 days.
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 2 ratings/reviews, Permapen has an overall score of 5.50. The effectiveness score is 6 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
Permapen review by 56 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Extremely Severe Side Effects|
|Condition / reason:|| || tooth infection|
|Dosage & duration:|| || 500mg taken twice a day for the period of 2 days|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || the pain in my tooth started to subside|
|Side effects:|| || I went into shock. My tongue swelled up, my face got very swollen. My heart was racing and I started to sweat something terrible. I was told that I was lucky not to die from taking this medication. |
|Comments:|| || I was rushed to the doctors office and given another drug to counter the effects of the penicillin. I was sick from the whole episode for a very long time. I am never suppose to take penicillin again or any drug that is a derivative of penicillin.|
Permapen review by 20 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Viral Bronchitis|
|Dosage & duration:|| || 250mg taken 3 x day for the period of 10 days|
|Other conditions:|| || None|
|Other drugs taken:|| || none|
|Benefits:|| || Absolutely no benefits, did not seem to get better even in a week. Through research I learned that penicillin does not treat a virus and that a virus must run its course. No idea why my doctor precribed Penicillin. Would rather he had been on the up and up about it instead of precribing a worthless treatment.|
|Side effects:|| || No side effects at all, just took an antibiotic I did not need and do not see any health benefit in that at all|
|Comments:|| || Doctor diagnosed me with Viral Bronchitis after and xray. He then prescribed Penicillin to treat it. Worthless treatment, since Penicillin is totally ineffective to fight a virus.|
Page last updated: 2014-12-01