PERMAPEN SUMMARY
PERMAPEN® ISOJECT®
(Penicillin G Benzathine)
Injectable Suspension
1,200,000 units
For lntramuscular Use Only
Permapen® (Penicillin G Benzathine) Injectable Suspension, a sterile antibacterial agent, is a repository penicillin compound which provides blood levels for long periods following its intramuscular injection. This property is the result of its extremely low solubility in water. Each milliliter contains 600,000 units of penicillin G benzathine; 0.006 grams sodium citrate; 0.003 grams polyvinylpyrrolidone; 0.010 grams lecithin, and 0.003 grams sodium carboxymethylcellulose in an aqueous suspension. Permapen also contains methylparaben 0.09% and propylparaben 0.01% as preservatives.
Intramuscular penicillin G benzathine is indicated in the treatment of infections in both children and adults due to penicillin G-susceptible microorganisms that are susceptible to the low and very prolonged serum levels common to this particular dosage form in the indications listed below. Therapy should be guided by clinical response.
Note: When high sustained serum levels are required, injectable penicillin G either IM or IV should be used.
The following infections will usually respond to adequate dosages of intramuscular penicillin G benzathine:
Upper Respiratory Tract (pharyngitis): streptococci (group A – without bacteremia).
Venereal Infections: Syphilis
Yaws, bejel, and pinta.
Medical Conditions in Which Penicillin G Benzathine Therapy is Indicated As Prophylaxis
Rheumatic fever and/or chorea: Prophylaxis with penicillin G benzathine has proven effective in preventing recurrence of these conditions. It has also been used as follow-up prophylactic therapy for rheumatic heart disease and acute glomerulonephritis.
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