NEWS HIGHLIGHTS
Published Studies Related to Periostat (Doxycycline Hyclate)
Administration of doxycycline in drinking water for treatment of spiral bacterial infection in cockatiels. [2008.02.01]
OBJECTIVE: To determine efficacy of providing drinking water medicated with doxycycline for treatment of spiral bacterial infection in cockatiels... CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that providing drinking water to which doxycycline had been added at a concentration of 400 mg/L was effective in eliminating spiral bacterial infections in cockatiels.
Regeneration of degree ii furcation defects with a 4% doxycycline hyclate bioabsorbable barrier. [2008.01]
BACKGROUND: Bacterial contamination of a healing regenerative site has been shown to affect the response to therapy adversely. Doxycycline possesses antibacterial properties as well as other biologic actions that may result in an increased production and maintenance of collagen and bone. The purpose of this study was to assess if the sustained release of 4% doxycycline through a bioabsorbable barrier would enhance the regenerative outcomes of healing furcation sites... CONCLUSIONS: Addition of doxycycline to the guided tissue regeneration barrier did not enhance treatment outcomes compared to the non-antibiotic-loaded barrier or bone graft alone. All treatment modalities provided similar improvement in clinical and intrasurgical parameters.
A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers. [2007.04]
CONCLUSIONS: This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers.
Pharmacokinetic and bioequivalence study of meloxicam tablets in healthy male subjects. [2007]
Meloxicam (CAS 71125-38-7), a non-steroidal anti-inflammatory drug (NSAID), is used for the treatment of osteoarthritis and rheumatic arthritis. In the present study, two different oral meloxicam formulations (Melcam 15 mg tablets as test preparation and tablets of a reference preparation) were investigated in 24 healthy male subjects in order to prove bioequivalence between both preparations...
The effect of topical doxycycline usage on gingival crevicular fluid MMP-8 levels of chronic and aggressive periodontitis patients: a pilot study. [2006.08]
The aim of this study was to evaluate the efficacy of topical subgingival application of doxycycline hyclate (DH) gel adjunctive to non-surgical periodontal therapy on gingival crevicular fluid (GCF) matrix metalloproteinase (MMP)-8 levels in chronic and aggressive periodontitis patients... Developing functional and immunological-based chair-side MMP tests might serve as useful adjunctive diagnostic tools when monitoring the effects of DH gel application.
Clinical Trials Related to Periostat (Doxycycline Hyclate)
Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions [Completed]
Bioequivalence Study Doxycycline Tablets and Monodox Capsules Under Fasting Conditions [Completed]
Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting Conditions [Completed]
Doxycycline Prophylaxis at Vacuum Aspiration Trial [Completed]
This study is a randomized, double-blinded, controlled trial comparing two regimens of
doxycycline for the prevention of infection after surgical abortion. One thousand women
undergoing surgical abortion in the first trimester will be enrolled from the clinic at Tu Du
Hospital, Ho Chi Minh City, Vietnam. The standard regimen has been 100 mg twice daily for 5
days after the abortion. Subjects will be randomized to the standard regimen or to take 200
mg doxycycline pre-operatively. Subjects found to have a positive Chlamydia EIA test will
receive a 7-day course of doxycycline regardless of study group. Subjects will complete
questionnaires of symptoms, including nausea and emesis in the recovery room after the
procedure and at a single follow-up visit two weeks later. The primary outcome will be
infection after abortion, defined below. Analyses will be performed including and excluding
Chlamydia-positive subjects. Secondary outcomes will be the proportion with nausea, emesis,
and other side-effects.
Fasting Study of Doxycycline Monohydrate Tablets 150 mg and Adoxa Tablets 150 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's doxycycline
monohydrate 150 mg tablets to Par's Adoxa® 150 mg tablets following a single, oral 150 mg (1
x 150 mg) dose administered under fasting conditions.
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