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Periostat (Doxycycline Hyclate) - Summary



PERIOSTAT® (doxycycline hyclate tablets)

Periostat® is available as a 20 mg tablet formulation of doxycycline for oral administration.

Periostat® is indicated for use as an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.

See all Periostat indications & dosage >>


Published Studies Related to Periostat (Doxycycline Hyclate)

Subantimicrobial-dose doxycycline treatment increases serum cholesterol efflux capacity from macrophages. [2013]
removal from macrophages... CONCLUSIONS: Our results suggest that SDD treatment may reduce the risk of

A study of the clinical activity of a gel combining monocaprin and doxycycline: a novel treatment for herpes labialis. [2012]
doxycycline in vivo against herpes labialis... CONCLUSION: Combining monocaprin with low-dose doxycycline offers an effective

Clinical studies on the management of periodontal diseases utilizing subantimicrobial dose doxycycline (SDD). [2011.02]
Periodontitis, the most common chronic inflammatory condition known to mankind, is a disease that results in the destruction of tooth supporting tissues. Periodontitis is initiated by a bacterial biofilm on the tooth surface below the gingival margin... This review paper begins with a brief description of the disease process known as periodontitis followed by an extensive review of the Phase I-IV clinical trial data that established the safety and efficacy of sub-antimicrobial dose doxycycline (SDD) as an adjunct to scaling and root planing for the treatment of periodontitis.

Comparative evaluation of the efficacy of 10% doxycycline hyclate in the periodontal treatment of smokers - a clinical and microbiological study. [2011]
PURPOSE: The aim of this present clinical and microbiological study was to evaluate the efficacy of the association of locally delivered 10% doxycycline hyclate (Atridox(R)) with scaling and root planing in the periodontal treatment of smokers... CONCLUSIONS: The use of locally delivered doxycycline may constitute an important adjunct for the treatment of chronic periodontitis in smokers.

Sub-antimicrobial doxycycline for periodontitis reduces hemoglobin A1c in subjects with type 2 diabetes: a pilot study. [2011]
In vitro and animal studies suggest a possible role for the tetracycline class of drugs in the inhibition of non-enzymatic protein glycation. We conducted a 3-month, randomized placebo-controlled pilot clinical trial of conventional sub-gingival debridement (periodontal therapy), combined with either a three month regimen of sub-antimicrobial-dose doxycycline (SDD), a two week regimen of antimicrobial-dose doxycycline (ADD), or placebo in 45 patients with long-standing type 2 diabetes (mean duration 9 years) and untreated chronic periodontitis...

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Clinical Trials Related to Periostat (Doxycycline Hyclate)

Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting and Fed Conditions [Completed]

Bioequivalence Study Doxycycline Tablets and Monodox Capsules Under Fasting Conditions [Completed]

Bioavailability Study of Doxycycline Monohydrate Capsules and Monodox Under Fasting Conditions [Completed]

Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea� vs Placebo After 12 Weeks of Oracea� and MetroGel� 1% [Recruiting]
The purpose of this study is to assess relapse, efficacy and safety in subjects with rosacea during long-term treatment with either Oracea or placebo, after an initial 12-week regimen of Oracea and MetroGel 1%.

Doxycycline Outcomes in Lupus Erythematosus: (DOLE) [Not yet recruiting]
Cardiovascular disease, specifically from atherosclerosis, is the major cause of mortality in SLE in developed countries. In a recent study the investigators have shown that high sensitivity C reactive protein (hs-CRP) is higher in SLE patients with (versus without) coronary calcium, a measure of subclinical atherosclerosis. In an ongoing two year intervention trial of atorvastatin, the investigators will determine if statins retard coronary calcium and reduce hs-CRP. However, 10% of the patients in the trial were intolerant of statins. The investigators want to now investigate whether there are additional, and potentially safer ways, to reduce hs-CRP in SLE. In this study, the investigators will determine if doxycycline reduces hs-CRP and other vascular inflammatory markers including interleukin 6 (IL-6), soluble vascular cell adhesion molecule (sVCAM-1), soluble inter cell adhesion molecule (s-ICAM-1) and matrix metalloproteinase 9 (MMP-9) in SLE.

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Based on a total of 1 ratings/reviews, Periostat has an overall score of 8. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.

Periostat review by 56 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Rosacea
Dosage & duration:   100 mg taken once a day for the period of 3 years
Other conditions:   None
Other drugs taken:   None
Reported Results
Benefits:   The drug prevents the pustules that can result from Rosacea. When I do not take the drug for a week, the pustules tend to reappear.
Side effects:   When I first started the drug, I felt nauseated for a few days. It gradually subsided. It helped to take the drug with food, although I initially was told to take it 2 hours after eating. Now I can tolerate it better, but still must take it at about the same time every day or it bothers my stomach and I get nauseated.
Comments:   My Rosacea had progressed to the second stage (pustules) before I was diagnosed. I woke up one morning with pustules on my face, and one was infected. I went immediately to a dermatologist, who diagnosed me with Rosacea and prescribed 200 mg of doxycycline daily. I tried that, but my stomach would not tolerate it. He lowered the dose to 100 mg, and I did better, although it took a few days to adjust.

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Page last updated: 2014-11-30

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