(Chlorhexidine Gluconate Oral Rinse, 0.12%)
PerioGard (Chlorhexidine Gluconate Oral Rinse, 0.12%) is an oral rinse containing 0.12% chlorhexidine gluconate [ N,N ”-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di- D -gluconate] in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No. 1. PerioGard Oral Rinse is a near-neutral solution (pH range 5-7).
PerioGard Oral Rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. PerioGard Oral Rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.
Published Studies Related to Periogard (Chlorhexidine)
Implant decontamination with 2% chlorhexidine during surgical peri-implantitis
treatment: a randomized, double-blind, controlled trial. 
CONCLUSIONS: The use of a 2% CHX solution for implant surface decontamination
A preliminary comparison of the effect of 0.3% versus 0.2% chlorhexidine mouth
rinse on de novo plaque formation: a monocentre randomized double-blind crossover
CONCLUSION: Chlorhexidine is an effective oral antiseptic. The CHX 0.3% mouth
Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base
mouthrinse efficacy on plaque control: double blind, randomized clinical trials. 
0.1% of Formaldehyde (CLX-F)... CONCLUSION: the results of this study showed that rinsing with an alcohol base
Using chlorhexidine varnish to prevent early childhood caries in American Indian
children... CONCLUSIONS: In this population CHX varnish did not reduce the mean NNCS or
Comparison of antibacterial effects of oral rinses chlorhexidine and herbal mouth
wash in patients admitted to intensive care unit. 
mouthwashes in intensive care unit patients... CONCLUSION: The herbal mouth wash has significant antibacterial effects against
Clinical Trials Related to Periogard (Chlorhexidine)
Flossing With Chlorhexidine [Completed]
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial
mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums
characterized by red, swollen, bleeding gums. And to determine if applying chlorhexidine via
dental floss would result in tooth staining, which is common with chlorhexidine mouthwashes.
Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan [Recruiting]
The investigators hypothesize that application of 4% Chlorhexidine to the cord stump and
meticulous hand washing by primary health care providers of newborn infants will reduce the
incidence of Omphalitis and thereby Neonatal Mortality as compared to standardized dry cord
Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics [Recruiting]
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics
are costly or ineffective. In order to have more options, this study is needed. The
investigators want to know if there are differences between the use of 2% chlorhexidine
gluconate in 70% isopropyl alcohol or 10% sodium hypochlorite.
Chlorhexidine Gel Therapy for Cariogenic Oral Microflora [Recruiting]
The goal of this clinical research study is to find out if 1% chlorhexidine gluconate gel
will decrease the amount of bacteria that causes tooth decay. Whether the gel is acceptable
to patients will also be studied.
Chlorhexidine Mouthwash and Bacterial Contamination During Endoscopy [Not yet recruiting]
Natural Orifice Transluminal Endoscopic Surgery (NOTES) is a surgical technique that has
been rapidly evolving over the last five years. The technique probably has a great potential
in surgical gastroenterology, urology and gynaecology.
The technique is based on the idea of minimally invasive surgery. The human organism is
affected by a stress response when exposed to surgery. This stress response can be minimized
by reducing the size of the openings whereby the surgeon gains access to the organs. This
affects how quickly a patient recovers after surgery and can be discharged and resumes daily
life and work. The same principal have been responsible for the surgical evolution in the
last 15-20 years where many procedures have gone from traditional open operations with large
incisions in the abdominal wall to laparoscopic surgery with cameras through small holes in
the abdominal wall.
The latest addition to minimal invasive surgery is NOTES. Here the surgeon gains access to
the abdominal organs with flexible endoscopes through the body's natural openings i. e. the
mouth and stomach. With this technique the surgeon avoids cutting through skin and muscle of
the abdominal wall, thus minimizing the surgical stress response. This minimizes
postoperative pain, the incidence of incisional hernias, eliminates wound infection, and
properly prevents scar tissue formation inside the abdominal cavity which way lead to ileus.
The end result is a quicker discharge and a better cosmetic result.
It has been shown in numerous animal studies that NOTES is feasible and in recent years a
rapidly increasing number of published patient series.
However, there is a risk of infection associated with accessing the abdominal cavity through
a natural body opening, which initially is unclean and can not be disinfected in the same
way as the skin of the abdominal wall.
Numerous microbiological pig studies have shown that there is transfer of bacteria from the
body opening (i. e. mouth) to the abdominal cavity when performing NOTES, but this
contamination have no correlation to infection after surgery, neither in terms of healing or
It is unclear from the literature whether patients should be offered proton pump inhibitor
(PPI) therapy to reduce the acidity of the stomach before NOTES interventions. The rationale
has been that such a treatment can make the gastric juices less acidic and thereby reduce
the incidence of chemical peritonitis, which can occur when acidic juices flows from the
stomach and into the abdominal cavity. It is known however that the acidic environment of
the stomach provides a natural barrier for bacteria. Making the gastric juices less acidic
could potentially increase the risk of bacterial peritonitis.
It is known that the bacterial content of the stomach is low due the acidic environment but
bacteria passed down from the mouth and throat with the endoscope could potentially result
in bacterial peritonitis.
That bacteria from the throat can lead to infections due to instrumentation is known from
intensive care units. Ventilated patients may risk getting pneumonia with bacteria from the
throat. Several studies have shown that using mouthwash with a chlorhexidine solution can
reduce the risk of ventilator associated pneumonia.
Mouthwash with 10 ml 0,2% chlorhexidine solution before a gastroscopy reduces the bacterial
content in cultures taken from the stomach and the endoscope after a gastroscopy.
Simultaneous PPI treatment gives higher bacterial counts in the cultures.
Reports of Suspected Periogard (Chlorhexidine) Side Effects
Cleft Palate (6),
Congenital Anomaly (6),
Emotional Disorder (6),
Cleft LIP (6),
Otitis Media Chronic (5),
Eustachian Tube Dysfunction (5),
Weight Decreased (1),
Maternal Drugs Affecting Foetus (1), more >>