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Periogard (Chlorhexidine Gluconate) - Summary

 
 



PERIOGARD SUMMARY

PerioGard (Chlorhexidine Gluconate Oral Rinse, 0.12%) is an oral rinse containing 0.12% chlorhexidine gluconate [ N,N ”-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di- D -gluconate] in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No. 1. PerioGard Oral Rinse is a near-neutral solution (pH range 5-7).

PerioGard Oral Rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. PerioGard Oral Rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.


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NEWS HIGHLIGHTS

Media Articles Related to Periogard (Chlorhexidine)

A common hospital soap may reduce MRSA spread
Source: Nursing / Midwifery News From Medical News Today [2015.05.14]
Researchers suggest patient care and reduction of MRSA and other hospital-acquired infections may both benefit from using the common hospital soap chlorhexidine to bathe patients.

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Published Studies Related to Periogard (Chlorhexidine)

Implant decontamination with 2% chlorhexidine during surgical peri-implantitis treatment: a randomized, double-blind, controlled trial. [2015]
CONCLUSIONS: The use of a 2% CHX solution for implant surface decontamination

Implant decontamination with 2% chlorhexidine during surgical peri-implantitis treatment: a randomized, double-blind, controlled trial. [2014]
CONCLUSIONS: The use of a 2% CHX solution for implant surface decontamination

Evaluation of the antigingivitis effect of a chlorhexidine mouthwash with or without an antidiscoloration system compared to placebo during experimental gingivitis. [2014]
accumulation, and gingivitis... CONCLUSIONS: CHX with an ADS did not prevent plaque or gingivitis development. In

A preliminary comparison of the effect of 0.3% versus 0.2% chlorhexidine mouth rinse on de novo plaque formation: a monocentre randomized double-blind crossover trial. [2013]
CONCLUSION: Chlorhexidine is an effective oral antiseptic. The CHX 0.3% mouth

Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base mouthrinse efficacy on plaque control: double blind, randomized clinical trials. [2013]
0.1% of Formaldehyde (CLX-F)... CONCLUSION: the results of this study showed that rinsing with an alcohol base

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Clinical Trials Related to Periogard (Chlorhexidine)

EXCEL: Change in Cardiometabolic Disease Risk Factors During an Interactive Fitness Program [Completed]
Childhood obesity has increased in prevalence over the past several decades and is predictive of adult type 2 diabetes and cardiovascular disease (CVD). Recent studies of children and youth suggest that exercise reduces cardiometabolic risk factors. Minimal data are available, however, on the effects of "exergaming" , interactive technology- mediated approaches to increasing physical activity in children and youth. This project involves a partnership between UMass Boston/GoKids Boston and Children's Hospital Boston featuring an interdisciplinary team of researchers and clinicians from pediatric cardiology, nursing, prevention and behavioral sciences and exercise physiology and is designed to examine the effects of exergaming on moderate or vigorous physical activity (MVPA) indices of adiposity, risk factors for cardiometabolic disease and self-competence in Boston Public School children. It is hypothesized that participation in the EXCEL/exergaming intervention for 60 minutes, three times per week for 12 weeks will significantly increase MVPA (as measured by accelerometers), pre- to- post intervention and compared to an Advice only (Nutrition Education) group. Results of this pilot study will guide and inform a larger study of exergaming in children from the Boston Public Schools.

Waterless Hand Cleansing With Chlorhexidine During the Perinatal Period [Recruiting]
Background (brief): 1. Burden: Neonatal death still unacceptably high in low income countries. The common causes of neonatal death are pneumonia, sepsis and omphalitis. Many neonatal infections occur because the mother's hands or the hands of the person who attended the birth are unclean. Our previous study found that there was substantial concern about excessive exposure of the mother or the neonate to water during handwashing because of the perception that frequent contact with water could lead to respiratory illness. 2. Knowledge gap: Chlorhexidine has been evaluated for use in hand hygiene applications in high-income countries, particularly in healthcare, but it has not been evaluated or promoted for hand cleansing at the household level in low- and middle-income countries. 3. Relevance: A waterless hand cleanser employing chlorhexidine would overcome important barriers to handwashing with soap, perceptions of cold resulting from exposure to water, and the time limitations perceived by mothers. Hypothesis: Mothers who are exposed to a chlorhexidine-based hand cleansing intervention will clean their hands (with chlorhexidine or soap and water) more frequently than mothers who are not exposed to the chlorhexidine-based hand cleansing program. Objectives: The primary objective 1. To demonstrate the behavioural impact of chlorhexidine-based hand hygiene intervention on hand cleansing of mothers during the neonatal period The secondary objectives 2. To demonstrate the impact of chlorhexidine-based hand hygiene intervention on hand cleansing of other family members, visitors to the neonate, and birth attendants during the neonatal period 3. To evaluate the acceptability of chlorhexidine for hand cleansing in the neonatal period among mothers, other family members, and birth attendants Methods: We propose a randomized controlled trial in a rural area of Bangladesh, with an active control. Randomization will be at the level of the participating pregnant woman. Each arm will include 150 participants. All intervention visits will follow baseline data collection. A trained health and hygiene promoter will carry out two visits in the antenatal period and one postnatal visit to deliver intervention messages. Outcome measures: 1. Observed hand cleansing behavior of mother with chlorhexidine or soap and water at critical times. 2. Observed hand cleansing behavior of other household members and visitors to home with chlorhexidine or soap and water at critical times.

Efficacy of 2% Chlorhexidine Gluconate in 70% Alcohol Compare 10% Povidone Iodine in Blood Culture in Children [Completed]
To evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.

Chlorhexidine Drying Time [Completed]
Before a patient gets a spinal/epidural, their lower back is cleaned with an antiseptic solution diluted in alcohol called ChloraPrep. ChloraPrep must completely dry before starting the anesthetic procedure. It is not known how much time is needed for the solution to completely dry. The investigators aim to determine this. As the ChloraPrep dries, the alcohol is converted into vapour. The investigators will be using a PPBRae 3000 device to detect small amounts of vapours in the air. As the ChloraPrep dries it gives off less and less vapour. The investigators will use this diminishing vapour concentration to determine when drying is complete.

Pilot Study: Safety of Chlorhexidine (CHG) Baths in Patients Less Than 2 Months of Age [Not yet recruiting]
Literature provides overwhelming evidence supporting the use of chlorhexidine gluconate (CHG) a rapid onset, broad spectrum, topical antiseptic for reducing healthcare-associated infections (HAIs). CHG is believed to be superior to other forms of antiseptics because, when it is applied to the skin surface, it leaves a lasting residue on the skin. CHG has been shown to be well tolerated in patients 2 months of age and older. However there is limited evidence to support the use of topically applied CHG in infants less than 2 months of age because of potential safety concerns in this population. The purpose of this study will be to describe the safety of bi-weekly CHG baths in a sample of Newborn Intensive Care Unit (NICU) and pediatric Cardiac Intensive Care Unit (CICU) patients by measuring the incidence of skin problems and CHG blood levels.

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Reports of Suspected Periogard (Chlorhexidine) Side Effects

Cleft Palate (6)Congenital Anomaly (6)Emotional Disorder (6)Cleft LIP (6)Otitis Media Chronic (5)Hydrocele (5)Eustachian Tube Dysfunction (5)Ageusia (2)Weight Decreased (1)Maternal Drugs Affecting Foetus (1)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Periogard has an overall score of 6. The effectiveness score is 6 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Periogard review by 54 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   dental surgery
Dosage & duration:   1/2 oz. twice daily (dosage frequency: twice daily) for the period of two weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   prevented infection of surgically sewn gums. They cut my gums and pulled them down further over the teeth and added a laboratory grown skin product to make the gum larger. I also used this periogard bottle when they put caps on my teeth, just to prevent infection.
Side effects:   I had no side effects, but was told the product could stain the teeth (which the dentist could alter back to white teeth), however, I wiped my teeth with a wash cloth after swishing with the product.
Comments:   The details were included in the two above sections.

 

Periogard review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   periodontal disease
Dosage & duration:   1 ounce (dosage frequency: 2 x per day) for the period of 3 months
Other conditions:   none
Other drugs taken:   periostat
  
Reported Results
Benefits:   None apparent during treatment.
Side effects:   Raised sores in mouth; attempted to mitigate side effect by rinsing only area with deepest periodontal pockets using syringe, continued to get sores localized to irrigated region.
Comments:   Rinsed mouth vigorously with solution, refrained from eating, drinking, brushing, etc for 1/2 hour after use. Used twice per day. After side effects noted, irrigated only some areas of mouth. Discontinued when sores persisted.

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Page last updated: 2015-08-10

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