(Chlorhexidine Gluconate Oral Rinse, 0.12%)
PerioGard (Chlorhexidine Gluconate Oral Rinse, 0.12%) is an oral rinse containing 0.12% chlorhexidine gluconate [ N,N ”-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di- D -gluconate] in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No. 1. PerioGard Oral Rinse is a near-neutral solution (pH range 5-7).
PerioGard Oral Rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. PerioGard Oral Rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.
Published Studies Related to Periogard (Chlorhexidine)
Comparison of antibacterial effects of oral rinses chlorhexidine and herbal mouth
wash in patients admitted to intensive care unit. 
mouthwashes in intensive care unit patients... CONCLUSION: The herbal mouth wash has significant antibacterial effects against
Dose assessment of 2% chlorhexidine acetate for canine superficial pyoderma. [2011.10]
The dose of 2% chlorhexidine acetate (2CA; Nolvasan((R)) Surgical Scrub; Fort Dodge Animal Health, Fort Dodge, IA, USA) for canine superficial pyoderma was evaluated...
Clinical evaluation of chlorhexidine for the control of dental biofilm in children with special needs. [2011.09]
CONCLUSIONS: The topical administration of chlorhexidine associated to tooth brushing led to a reduction in dental biofilm and gingival bleeding in children with special needs. Administration in spray form proved easier and was preferred by parents/caregivers.
Early, single chlorhexidine application reduces ventilator-associated pneumonia in trauma patients. [2011.09]
BACKGROUND: Ventilator-associated pneumonia (VAP) is an important complication of mechanical ventilation and is particularly common in trauma, burn, and surgical patients. Interventions that kill bacteria in the oropharynx reduce the pool of viable organisms available for translocation to the lung and thereby lessen the likelihood of developing VAP. Repeated administration of chlorhexidine (CHX) to the mouth and oropharynx has been shown to reduce the incidence of VAP, but use of a single dose has not been studied. This randomized, controlled clinical trial tested an early (within 12 hours of intubation) application of CHX by swab versus control (no swab) on oral microbial flora and VAP... CONCLUSION: an early, single application of CHX to the oral cavity significantly reduces CPIS and thus VAP in trauma patients. Copyright (c) 2011 Elsevier Inc. All rights reserved.
A novel approach to the use of subgingival controlled-release chlorhexidine delivery in chronic periodontitis: a randomized clinical trial. [2011.08]
BACKGROUND: We aimed to analyze clinical, microbiologic, and serologic effects of chlorhexidine (CHX) chips used as a subgingival controlled-release delivery device before and immediately after scaling and root planing (SRP)... CONCLUSION: The use of CHX chips before and immediately after SRP improved CAL and reduced the subgingival microorganisms of the red complex in the treatment of chronic periodontitis.
Clinical Trials Related to Periogard (Chlorhexidine)
Flossing With Chlorhexidine [Completed]
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial
mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums
characterized by red, swollen, bleeding gums. And to determine if applying chlorhexidine via
dental floss would result in tooth staining, which is common with chlorhexidine mouthwashes.
Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan [Recruiting]
The investigators hypothesize that application of 4% Chlorhexidine to the cord stump and
meticulous hand washing by primary health care providers of newborn infants will reduce the
incidence of Omphalitis and thereby Neonatal Mortality as compared to standardized dry cord
Efficacy Study Comparing 2% Chlorhexidine in 70% Isopropyl Alcohol Versus 2% Aqueous Chlorhexidine [Recruiting]
The purpose of this study is to compare the efficacy of two different antiseptic solutions
(2%chlorhexidine in 70% alcohol with 2% aqueous chlorhexidine)when used in a standardized
controlled manner in cleansing the skin of infants with birth weight less than 1500 grams
prior to a skin breaking procedure (venepuncture).
The investigators hypothesize that the use of limited amount of 2% aqueous chlorhexidine
solution will be as effective as the same amount of 2% chlorhexidine in 70% alcohol for skin
antisepsis and that limited exposure to 2% aqueous CHG may be associated with less adverse
Literature from adults has shown that both 2% chlorhexidine in 70% alcohol as well as 2%
aqueous chlorhexidine can provide effective skin antisepsis though alcohol containing
solution had more long lasting effect. It is also well known from many case reports that
alcohol containing products when used to clean abdominal skin for neonatal procedures can
cause severe skin damage in preterm infants. This has lead many neonatal units to adopt
aqueous chlorhexidine as the antiseptic agent of choice without robust evidence to support
its use or standardization of method of application. Both these solutions are widely used in
neonatal intensive care units across the globe including Canada.
By conducting this trial, the investigators want to evaluate the efficacy and safety of 2%
aqueous chlorhexidine as an antiseptic agent when used in a controlled manner [limited
amount for short duration].
Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics [Recruiting]
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics
are costly or ineffective. In order to have more options, this study is needed. The
investigators want to know if there are differences between the use of 2% chlorhexidine
gluconate in 70% isopropyl alcohol or 10% sodium hypochlorite.
Chlorhexidine Gel Therapy for Cariogenic Oral Microflora [Recruiting]
The goal of this clinical research study is to find out if 1% chlorhexidine gluconate gel
will decrease the amount of bacteria that causes tooth decay. Whether the gel is acceptable
to patients will also be studied.
Reports of Suspected Periogard (Chlorhexidine) Side Effects
Cleft Palate (6),
Congenital Anomaly (6),
Emotional Disorder (6),
Cleft LIP (6),
Otitis Media Chronic (5),
Eustachian Tube Dysfunction (5),
Weight Decreased (1),
Maternal Drugs Affecting Foetus (1), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 2 ratings/reviews, Periogard has an overall score of 6. The effectiveness score is 6 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Periogard review by 54 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || dental surgery|
|Dosage & duration:|| || 1/2 oz. twice daily (dosage frequency: twice daily) for the period of two weeks|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || prevented infection of surgically sewn gums. They cut my gums and pulled them down further over the teeth and added a laboratory grown skin product to make the gum larger. I also used this periogard bottle when they put caps on my teeth, just to prevent infection. |
|Side effects:|| || I had no side effects, but was told the product could stain the teeth (which the dentist could alter back to white teeth), however, I wiped my teeth with a wash cloth after swishing with the product.|
|Comments:|| || The details were included in the two above sections.|
Periogard review by 37 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Ineffective|
|Side effects:|| || Moderate Side Effects|
|Condition / reason:|| || periodontal disease|
|Dosage & duration:|| || 1 ounce (dosage frequency: 2 x per day) for the period of 3 months|
|Other conditions:|| || none|
|Other drugs taken:|| || periostat|
|Benefits:|| || None apparent during treatment.|
|Side effects:|| || Raised sores in mouth; attempted to mitigate side effect by rinsing only area with deepest periodontal pockets using syringe, continued to get sores localized to irrigated region.|
|Comments:|| || Rinsed mouth vigorously with solution, refrained from eating, drinking, brushing, etc for 1/2 hour after use. Used twice per day. After side effects noted, irrigated only some areas of mouth. Discontinued when sores persisted.|
Page last updated: 2013-02-10