Periogard (Chlorhexidine Gluconate) - Summary

PERIOGARD SUMMARY

PerioGard^®
(Chlorhexidine Gluconate Oral Rinse, 0.12%)

PerioGard (Chlorhexidine Gluconate Oral Rinse, 0.12%) is an oral rinse containing 0.12% chlorhexidine gluconate [ N,N ”-bis (4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide di- D -gluconate] in a base containing water, 11.6% alcohol, glycerin, PEG-40 sorbitan diisostearate, flavor, sodium saccharin, and FD&C Blue No. 1. PerioGard Oral Rinse is a near-neutral solution (pH range 5-7).

PerioGard Oral Rinse is indicated for use between dental visits as part of a professional program for the treatment of gingivitis as characterized by redness and swelling of the gingivae, including gingival bleeding upon probing. PerioGard Oral Rinse has not been tested among patients with acute necrotizing ulcerative gingivitis (ANUG). For patients having coexisting gingivitis and periodontitis, see PRECAUTIONS.

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NEWS HIGHLIGHTS

Published Studies Related to Periogard (Chlorhexidine)

Effectiveness of oral rinse with chlorhexidine in preventing nosocomial respiratory tract infections among intensive care unit patients. [2009.10]
OBJECTIVE: To evaluate the effectiveness of the oral application of a 0.12% solution of chlorhexidine for prevention of respiratory tract infections among intensive care unit (ICU) patients... CONCLUSION: Oral application of a 0.12% solution of chlorhexidine does not prevent respiratory tract infections among ICU patients, although it may retard their onset.

Echinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial. [2009.09.01]
BACKGROUND: The aim of this trial was to assess the relative efficacy of a sage/echinacea spray and a chlorhexidine/lidocaine spray in the treatment of acute sore throats... CONCLUSION: An echinacea/sage preparation is as efficacious and well tolerated as a chlorhexidine/lidocaine spray in the treatment of acute sore throats.

Chlorhexidine, toothbrushing, and preventing ventilator-associated pneumonia in critically ill adults. [2009.09]
BACKGROUND: Ventilator-associated pneumonia is associated with increased morbidity and mortality. OBJECTIVE: To examine the effects of mechanical (toothbrushing), pharmacological (topical oral chlorhexidine), and combination (toothbrushing plus chlorhexidine) oral care on the development of ventilator-associated pneumonia in critically ill patients receiving mechanical ventilation... CONCLUSIONS: Chlorhexidine, but not toothbrushing, reduced early ventilator-associated pneumonia in patients without pneumonia at baseline.

Effect of chlorhexidine-thymol varnish on root caries in a geriatric population: a randomized double-blind clinical trial. [2009.09]
OBJECTIVES: Little is known about the effect of Cervitec, a chlorhexidine-thymol varnish, on root caries. Our objective was to determine whether a 3-monthly application of Cervitec over 1 year would limit the progress of existing root caries lesions and reduce the incidence of dental root caries in a group of dentate institutionalized elderly, as a complement to their usual oral hygiene practices... CONCLUSION: According to these results, Cervitec may help to control established root lesions and reduce the incidence of root caries lesion among institutionalized elderly.

Comparison of surgical wound infection after preoperative skin preparation with 4% chlorhexidine [correction of chlohexidine] and povidone iodine: a prospective randomized trial. [2009.07]
CONCLUSION: Colonization of bacterial and postoperative surgical wound infection were significantly reduced in the chlorhexidine group. Chlorhexidine antiseptic should be the first consideration for preoperative skin preparation.

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Clinical Trials Related to Periogard (Chlorhexidine)

Flossing With Chlorhexidine [Completed]
To determine if flossing with a dental floss presoaked in chlorhexidine, an anti-microbial mouth wash, would improve the clinical signs of gingivitis, an inflammation of the gums characterized by red, swollen, bleeding gums. And to determine if applying chlorhexidine via dental floss would result in tooth staining, which is common with chlorhexidine mouthwashes.

A Study of Chlorhexidine in the Prevention of HIV-1 Transmission From Mothers to Their Babies [Active, not recruiting]
The purpose of this study is to find the best strength of chlorhexidine (a solution that kills germs), for washing the mother's vagina during labor and the newborn baby, that may reduce the chance of HIV being passed from an HIV-positive mother to the baby.

When used as a wash on the vagina during labor, and on a newborn shortly after birth, a higher dose of chlorhexidine is more likely to reduce the rate of HIV-1 transmission from mother to baby. Laboratory tests suggest that a higher dose of chlorhexidine will be more effective in killing HIV.

Whole Body Washing With Chlorhexidine for the Eradication of MRSA [Completed]
The purpose of this study is to determine whether whole body washing with chlorhexidine in combination with mupirocine nasal ointment is effective in the eradication of meticillin-resistant Staphylococcus aureus (MRSA).

Effect of Chlorhexidine Cleansing on Skin Flora of Newborns in Nepal [Completed]
The purpose of this study is to compare the reductions in skin flora of newborns after a single cleansing of the body with three concentrations of chlorhexidine (0. 25%, 0. 5%, 1. 0%) and to examine the safety of skin cleansing in neonates in Nepal.

Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan [Recruiting]
The investigators hypothesize that application of 4% Chlorhexidine to the cord stump and meticulous hand washing by primary health care providers of newborn infants will reduce the incidence of Omphalitis and thereby Neonatal Mortality as compared to standardized dry cord care.

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PATIENT REVIEWS / RATINGS / COMMENTS

Periogard review by 37 year old female patient
		Rating
Overall rating:
Effectiveness:		Ineffective
Side effects:		Moderate Side Effects
		Treatment Info
Condition / reason:		periodontal disease
Dosage & duration:		1 ounce (dosage frequency: 2 x per day) for the period of 3 months
Other conditions:		none
Other drugs taken:		periostat
		Reported Results
Benefits:		None apparent during treatment.
Side effects:		Raised sores in mouth; attempted to mitigate side effect by rinsing only area with deepest periodontal pockets using syringe, continued to get sores localized to irrigated region.
Comments:		Rinsed mouth vigorously with solution, refrained from eating, drinking, brushing, etc for 1/2 hour after use. Used twice per day. After side effects noted, irrigated only some areas of mouth. Discontinued when sores persisted.