PerioChip® (chlorhexidine gluconate) is a small, orange-brown, rectangular chip (rounded at one end) for insertion into periodontal pockets. Each PerioChip weighs approximately 7.4 mg and contains 2.5 mg of chlorhexidine gluconate in a biodegradable matrix of hydrolyzed gelatin (cross-linked with glutaraldehyde). PerioChip also contains glycerin and purified water.
Chlorhexidine gluconate is an antimicrobial agent.
PerioChip is indicated as an adjunct to scaling and root planing procedures for reduction of pocket depth in patients with adult periodontitis. PerioChip may be used as a part of a periodontal maintenance program, which includes good oral hygiene and scaling and root planing.
Media Articles Related to Periochip (Chlorhexidine)
Chlorhexidine Bath in ICU Called Into Question
Source: Medscape Infectious Diseases Headlines [2015.01.22]
A large study of five intensive care units showed no reduction in hospital-acquired infections with the use of chlorhexidine, but a smaller study did find it helped.
Medscape Medical News
Antiseptic Baths Yield Mixed Results in ICU (CME/CE)
Source: MedPage Today Infectious Disease [2015.01.22]
(MedPage Today) -- Chlorhexidine baths protected against infection in one single-center trial, not in another.
Published Studies Related to Periochip (Chlorhexidine)
Implant decontamination with 2% chlorhexidine during surgical peri-implantitis
treatment: a randomized, double-blind, controlled trial. 
CONCLUSIONS: The use of a 2% CHX solution for implant surface decontamination
A preliminary comparison of the effect of 0.3% versus 0.2% chlorhexidine mouth
rinse on de novo plaque formation: a monocentre randomized double-blind crossover
CONCLUSION: Chlorhexidine is an effective oral antiseptic. The CHX 0.3% mouth
Chlorhexidine alcohol base mouthrinse versus Chlorhexidine formaldehyde base
mouthrinse efficacy on plaque control: double blind, randomized clinical trials. 
0.1% of Formaldehyde (CLX-F)... CONCLUSION: the results of this study showed that rinsing with an alcohol base
Using chlorhexidine varnish to prevent early childhood caries in American Indian
children... CONCLUSIONS: In this population CHX varnish did not reduce the mean NNCS or
Comparison of antibacterial effects of oral rinses chlorhexidine and herbal mouth
wash in patients admitted to intensive care unit. 
mouthwashes in intensive care unit patients... CONCLUSION: The herbal mouth wash has significant antibacterial effects against
Clinical Trials Related to Periochip (Chlorhexidine)
Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan [Recruiting]
The investigators hypothesize that application of 4% Chlorhexidine to the cord stump and
meticulous hand washing by primary health care providers of newborn infants will reduce the
incidence of Omphalitis and thereby Neonatal Mortality as compared to standardized dry cord
The Efficacy and Safety of 2.5 mg Chlorhexidine Gluconate Chip (PerioChip´┐Ż) in Frequent Treatment Versus Routine Treatment in Therapy of Adult Chronic Periodontitis [Recruiting]
Chlorhexidine Against Sodium Hypochlorite as Skin Antiseptics [Recruiting]
The physicians have few options for skin antisepsis. Alternatives for common use antiseptics
are costly or ineffective. In order to have more options, this study is needed. The
investigators want to know if there are differences between the use of 2% chlorhexidine
gluconate in 70% isopropyl alcohol or 10% sodium hypochlorite.
The Efficacy and Safety of Chlorhexidine Gluconate Chip (Periochip«) in Therapy of Symptoms in Patients With Peri-implantitis [Recruiting]
The purpose of the study is to assess the efficacy and the safety of Chlorhexidine Gluconate
chip (Periochip«) versus Placebo Chip in treatment of symptoms in patients with
Chlorhexidine Gel Therapy for Cariogenic Oral Microflora [Recruiting]
The goal of this clinical research study is to find out if 1% chlorhexidine gluconate gel
will decrease the amount of bacteria that causes tooth decay. Whether the gel is acceptable
to patients will also be studied.