NEWS HIGHLIGHTSMedia Articles Related to Peridex (Chlorhexidine)
Health Tip: At Risk for Gingivitis
Source: MedicineNet Dental Injuries Specialty [2009.02.25]
Title: Health Tip: At Risk for Gingivitis
Category: Health News
Created: 2/25/2009 2:00:00 AM
Last Editorial Review: 2/25/2009
Published Studies Related to Peridex (Chlorhexidine)
Effect of 2% chlorhexidine on dentin microtensile bond strengths and nanoleakage of luting cements. [2009.06]
OBJECTIVES: The aim of this study was to investigate the effect of pre-treatment by chlorhexidine on the microtensile bond strength (mTBS) of resin cements and nanoleakage at the resin-dentine interfaces... CONCLUSIONS: Pre-treatment with chlorhexidine affected the integrity of dentine bonding with PF and UC, while there was no adverse effect on coupling of ARC.
Microleakage in resin composite restorations after antimicrobial pre-treatments: effect of KTP laser, chlorhexidine gluconate and Clearfil Protect Bond. [2009.05]
The current study evaluated the influence of KTP (Potassium-Titanyl-Phosphate) laser irradiation, 2% chlorhexidine gluconate and Clearfil Protect Bond on the microleakage of Class V composite restorations. Thirty human premolars were selected for cavity pretreatment... Microleakage at the occlusal margins of all the groups was compared; differences between the KTP laser and chlorhexidine gluconate group and the KTP laser and Clearfil Protect Bond group were found to be statistically significant (p < 0.05).
Chlorhexidine-impregnated sponges and less frequent dressing changes for prevention of catheter-related infections in critically ill adults: a randomized controlled trial. [2009.03.25]
CONTEXT: Use of a chlorhexidine gluconate-impregnated sponge (CHGIS) in intravascular catheter dressings may reduce catheter-related infections (CRIs). Changing catheter dressings every 3 days may be more frequent than necessary. OBJECTIVE: To assess superiority of CHGIS dressings regarding the rate of major CRIs (clinical sepsis with or without bloodstream infection) and noninferiority (less than 3% colonization-rate increase) of 7-day vs 3-day dressing changes... CONCLUSIONS: Use of CHGIS dressings with intravascular catheters in the intensive care unit reduced risk of infection even when background infection rates were low. Reducing the frequency of changing unsoiled adherent dressings from every 3 days to every 7 days modestly reduces the total number of dressing changes and appears safe. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00417235.
Prevention of central venous catheter related infections with chlorhexidine gluconate impregnated wound dressings: a randomized controlled trial. [2009.03]
The objective of the study was to evaluate the effectiveness of chlorhexidine-impregnated sponges for reducing catheter-related infections of central venous catheters inserted for cancer chemotherapy. The method used was a randomized, prospective, open, controlled clinical study (three-step group sequential analysis protocol)...
Evaluation of the substantivity in saliva of different forms of application of chlorhexidine. [2009.02]
CONCLUSION: The 0.2% solution of CHX had the greatest sustained antimicrobial effect on the salivary flora, confirming the influence of the concentration and form of application on CHX substantivity.
Clinical Trials Related to Peridex (Chlorhexidine)
Topical Application of Chlorhexidine to the Umbilical Cord for Prevention of Omphalitis and Neonatal Mortality in Rural District of Pakistan [Recruiting]
The investigators hypothesize that application of 4% Chlorhexidine to the cord stump and
meticulous hand washing by primary health care providers of newborn infants will reduce the
incidence of Omphalitis and thereby Neonatal Mortality as compared to standardized dry cord
care.
Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) [Not yet recruiting]
Continuous femoral nerve block (CFNB) techniques continue to be increasingly used in the
management of postoperative pain after total knee arthroplasty. Although the risk of full
blown infection with CFNB has been poorly defined, the rate of catheter colonization after
antisepsis with povidone-iodine has been demonstrated to be high (Cuivillion et al. showed
the rate of colonization to be 57% after 48 hours). Recently, several anecdotal case reports
have demonstrated severe infectious complications including psoas abscess and necrotizing
fasciitis associated with continuous nerve block techniques. As the use of CFNB techniques
increase in popularity, infectious complications will undoubtedly become more common.
The American Society of Regional Anesthesia and Pain Medicine recommends the routine use of
antiseptic solutions with an alcohol base for skin disinfection before peripheral regional
techniques due to their penetration of the stratum corneum and their rapid and prolonged
effect. Chlorhexidine(chloraprep) has been proven to be better than povidone iodine solution
for skin preparation before epidural catheter and intravascular device insertion (Kinirons
et al., Ostrander et al., Mimoz et al.,). The goal of this prospective trial therefore is to
determine if an alcoholic solution of 0. 5% chlorhexidine is more effective than an aqueous
solution of 10% povidone-iodine in reducing catheter colonization and reducing skin flora
associated with short term ( 48 hours) postoperative continuous femoral nerve catheter
placement. The investigators will also compare the ability of chloraprep and betadine
disinfection at the time of catheter placement to prevent bacterial contamination of the
continuous femoral catheter.
The Efficacy and Safety of PerioChip Plus (Flurbiprofen/Chlorhexidine) Formulation in the Therapy of Adult Periodontitis [Not yet recruiting]
Cost-Effectiveness Study Comparing Chlorhexidine Bathing With Active Surveillance Cultures to Prevent MRSA & Other Hospital Infections [Recruiting]
This pilot study in our medical intensive care unit will evaluate the clinical and
cost-effectiveness of an active surveillance program for methicillin-resistant Staphylococcus
aureus (MRSA), compared to routine daily bathing with chlorhexidine gluconate
(CHG)-impregnated cloths. Outcomes include rate of MRSA acquisition, and of other
hospital-acquired infections (e. g., catheter-associated bloodstream infections).
A Comparison of Surgical Preparations and Wound Infection Rates for Elective Cesarean Sections [Recruiting]
The purpose of this study is to find out if chlorhexidine gluconate solution is better at
reducing the rate of wound infection after cesarean section compared to povidone-iodine.
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