ADVERSE REACTIONS
Serious adverse reactions that may be associated with PERCOCET tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock (see OVERDOSAGE).
The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus.
Hypersensitivity reactions may include: Skin eruptions, urticarial, erythematous skin reactions. Hematologic reactions may include: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.
Other adverse reactions obtained from postmarketing experiences with PERCOCET tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:
Body as a Whole
Anaphylactoid reaction, allergic reaction, malaise, asthenia, fatigue, chest pain, fever, hypothermia, thirst, headache, increased sweating, accidental overdose, non-accidental overdose
Cardiovascular
Hypotension, hypertension, tachycardia, orthostatic hypotension, bradycardia, palpitations, dysrhythmias
Central and Peripheral Nervous System
Stupor, tremor, paraesthesia, hypoaesthesia, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion, dizziness
Fluid and Electrolyte
Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis
Gastrointestinal
Dyspepsia, taste disturbances, abdominal pain, abdominal distention, sweating increased, diarrhea, dry mouth, flatulence, gastro-intestinal disorder, nausea, vomiting, pancreatitis, intestinal obstruction, ileus
Hepatic
Transient elevations of hepatic enzymes, increase in bilirubin, hepatitis, hepatic failure, jaundice, hepatotoxicity, hepatic disorder
Hearing and Vestibular
Hearing loss, tinnitus
Hematologic
Thrombocytopenia
Hypersensitivity
Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction
Metabolic and Nutritional
Hypoglycemia, hyperglycemia, acidosis, alkalosis
Musculoskeletal
Myalgia, rhabdomyolysis
Ocular
Miosis, visual disturbances, red eye
Psychiatric
Drug dependence, drug abuse, insomnia, confusion, anxiety, agitation, depressed level of consciousness, nervousness, hallucination, somnolence, depression, suicide
Respiratory System
Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema
Skin and Appendages
Erythema, urticaria, rash, flushing
Urogenital
Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention
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REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO PERCOCET
Below is a sample of reports where side effects / adverse reactions may be related to Percocet. The information is not vetted and should not be cosidered as verified clinical evidence.
Possible Percocet side effects / adverse reactions in 26 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-05
Patient: 26 year old male weighing 68.0 kg (149.6 pounds)
Reactions: Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Hypotension, Drug Abuser, Pulse Absent, Haematemesis, Loss of Consciousness
Adverse event resulted in: life threatening event, hospitalization
Suspect drug(s):
Acetaminophen
Dosage: po
Administration route: Oral
Percocet
Dosage: po
Administration route: Oral
Other drugs received by patient: Oxycodone/acetaminophen; Fentanyl Transdermal System
Possible Percocet side effects / adverse reactions in 27 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-16
Patient: 27 year old male
Reactions: Legal Problem, Drug Dependence, Substance Abuse
Adverse event resulted in: disablity
Suspect drug(s):
Oxycontin
Dosage: unk mg, unk
Indication: Drug Dependence
Percocet
Indication: Drug USE FOR Unknown Indication
Possible Percocet side effects / adverse reactions in 74 year old male
Reported by a individual with unspecified qualification from United States on 2007-01-31
Patient: 74 year old male weighing 86.6 kg (190.5 pounds)
Reactions: Vomiting
Suspect drug(s):
Percocet
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