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Percocet (Oxycodone Hydrochloride / Acetaminophen) - Side Effects and Adverse Reactions



Serious adverse reactions that may be associated with PERCOCET tablet use include respiratory depression, apnea, respiratory arrest, circulatory depression, hypotension, and shock (see OVERDOSAGE).

The most frequently observed non-serious adverse reactions include lightheadedness, dizziness, drowsiness or sedation, nausea, and vomiting. These effects seem to be more prominent in ambulatory than in nonambulatory patients, and some of these adverse reactions may be alleviated if the patient lies down. Other adverse reactions include euphoria, dysphoria, constipation, and pruritus.

Hypersensitivity reactions may include: Skin eruptions, urticarial, erythematous skin reactions. Hematologic reactions may include: Thrombocytopenia, neutropenia, pancytopenia, hemolytic anemia. Rare cases of agranulocytosis has likewise been associated with acetaminophen use. In high doses, the most serious adverse effect is a dose-dependent, potentially fatal hepatic necrosis. Renal tubular necrosis and hypoglycemic coma also may occur.

Other adverse reactions obtained from postmarketing experiences with PERCOCET tablets are listed by organ system and in decreasing order of severity and/or frequency as follows:

Body as a Whole

Anaphylactoid reaction, allergic reaction, malaise, asthenia, fatigue, chest pain, fever, hypothermia, thirst, headache, increased sweating, accidental overdose, non-accidental overdose


Hypotension, hypertension, tachycardia, orthostatic hypotension, bradycardia, palpitations, dysrhythmias

Central and Peripheral Nervous System

Stupor, tremor, paraesthesia, hypoaesthesia, lethargy, seizures, anxiety, mental impairment, agitation, cerebral edema, confusion, dizziness

Fluid and Electrolyte

Dehydration, hyperkalemia, metabolic acidosis, respiratory alkalosis


Dyspepsia, taste disturbances, abdominal pain, abdominal distention, sweating increased, diarrhea, dry mouth, flatulence, gastro-intestinal disorder, nausea, vomiting, pancreatitis, intestinal obstruction, ileus


Transient elevations of hepatic enzymes, increase in bilirubin, hepatitis, hepatic failure, jaundice, hepatotoxicity, hepatic disorder

Hearing and Vestibular

Hearing loss, tinnitus




Acute anaphylaxis, angioedema, asthma, bronchospasm, laryngeal edema, urticaria, anaphylactoid reaction

Metabolic and Nutritional

Hypoglycemia, hyperglycemia, acidosis, alkalosis


Myalgia, rhabdomyolysis


Miosis, visual disturbances, red eye


Drug dependence, drug abuse, insomnia, confusion, anxiety, agitation, depressed level of consciousness, nervousness, hallucination, somnolence, depression, suicide

Respiratory System

Bronchospasm, dyspnea, hyperpnea, pulmonary edema, tachypnea, aspiration, hypoventilation, laryngeal edema

Skin and Appendages

Erythema, urticaria, rash, flushing


Interstitial nephritis, papillary necrosis, proteinuria, renal insufficiency and failure, urinary retention


Below is a sample of reports where side effects / adverse reactions may be related to Percocet. The information is not vetted and should not be considered as verified clinical evidence.

Possible Percocet side effects / adverse reactions in 23 year old male

Reported by a consumer/non-health professional from United States on 2011-10-13

Patient: 23 year old male

Reactions: GUN Shot Wound, Drug Abuse

Adverse event resulted in: death

Suspect drug(s):
    Indication: Drug Abuse

    Indication: Drug Abuse

Possible Percocet side effects / adverse reactions in 22 year old female

Reported by a physician from United States on 2011-10-20

Patient: 22 year old female weighing 57.8 kg (127.2 pounds)

Reactions: Multiple Drug Overdose, Intentional Self-Injury, Loss of Consciousness

Adverse event resulted in: hospitalization

Suspect drug(s):
    Indication: Product Used FOR Unknown Indication

    Indication: Product Used FOR Unknown Indication

    Indication: Product Used FOR Unknown Indication

Codeine Sulfate
    Indication: Product Used FOR Unknown Indication

Cyclobenzaprine Hydrochloride
    Indication: Self Injurious Behaviour

    Indication: Product Used FOR Unknown Indication

    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Contraceptives

Possible Percocet side effects / adverse reactions in 53 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-21

Patient: 53 year old male weighing 85.0 kg (187.0 pounds)

Reactions: Pain, Oesophageal Obstruction, Skin Ulcer, Hypocalcaemia, Abdominal Distension, Decreased Appetite, Malabsorption, Vomiting, Stomatitis, Hyperglycaemia, Hypotension, Device Intolerance, Abdominal Infection, Sepsis, Dehydration, Hypoalbuminaemia

Adverse event resulted in: hospitalization

Suspect drug(s):


    Indication: Head and Neck Cancer
    Start date: 2008-08-18
    End date: 2008-08-18

See index of all Percocet side effect reports >>

Drug label data at the top of this Page last updated: 2013-02-13

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