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WARNING
Hepatotoxicity
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.
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PERCOCET SUMMARY
Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen.
PERCOCET is indicated for the relief of moderate to moderately severe pain.
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NEWS HIGHLIGHTSMedia Articles Related to Percocet (Oxycodone / Acetaminophen)
The Opioid Crisis and Need for Compassion in Pain Management
Source: Medscape Anesthesiology Headlines [2017.09.28]
In this commentary, the author expresses concern that the response to the public health crisis of opioid addiction is creating a growing crisis of inadequate pain management.
American Journal of Public Health
CVS to Restrict Opioid Painkiller Prescription Amounts
Source: MedicineNet Drug Abuse Specialty [2017.09.25]
Title: CVS to Restrict Opioid Painkiller Prescription Amounts
Category: Health News
Created: 9/22/2017 12:00:00 AM
Last Editorial Review: 9/25/2017 12:00:00 AM
Stomach Pain Quiz: Nausea & Other Causes
Source: MedicineNet Anal Fissure Specialty [2017.09.19]
Title: Stomach Pain Quiz: Nausea & Other Causes
Category: MedicineNet Quiz
Created: 1/20/2011 12:00:00 AM
Last Editorial Review: 9/19/2017 5:59:56 PM
Back Pain Quiz: Test Your Back Pain IQ
Source: MedicineNet Ankylosing Spondylitis Specialty [2017.09.19]
Title: Back Pain Quiz: Test Your Back Pain IQ
Category: MedicineNet Quiz
Created: 6/16/2011 3:41:00 PM
Last Editorial Review: 9/19/2017 6:39:04 PM
Pain Quiz: Test Your IQ of Pain
Source: MedicineNet Constipation Specialty [2017.09.19]
Title: Pain Quiz: Test Your IQ of Pain
Category: MedicineNet Quiz
Created: 7/14/2011 3:53:00 PM
Last Editorial Review: 9/19/2017 6:41:41 PM
Published Studies Related to Percocet (Oxycodone / Acetaminophen)
Comparison of subjective effects of extended-release versus immediate-release
oxycodone/acetaminophen tablets in healthy nondependent recreational users of
prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than
Comparison of the efficacy and safety of dual-opioid treatment with morphine plus
oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after
total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose
Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.
Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. [2007.07]
BACKGROUND: Oral opioid formulations contribute to postoperative analgesia. In this study, we evaluated the perioperative application of oral controlled-release oxycodone to reduce postoperative IV morphine consumption and opioid side effects after lumbar discectomy... CONCLUSIONS: Perioperative oral controlled-release oxycodone reduces postoperative IV morphine consumption after lumbar discectomy while providing good analgesia with fewer side effects compared with placebo.
Efficacy and tolerability of once-daily OROS hydromorphone and twice-daily extended-release oxycodone in patients with chronic, moderate to severe osteoarthritis pain: results of a 6-week, randomized, open-label, noninferiority analysis. [2007.05]
OBJECTIVE: This study compared the efficacy and tolerability of a once-daily controlled-release formulation of hydromorphone (OROS) hydromorphone, Janssen-Cilag, Beerse, Belgium) and twice-daily extended-release (ER) oxycodone in patients with chronic, moderate to severe osteoarthritis (OA) pain. OROS hydromorphone is currently available only in Europe... CONCLUSIONS: Once-daily OROS hydromorphone and twice-daily ER oxycodone provided similar pain relief in these patients with OA of the knee or hip. The tolerability profiles of the 2 agents were similar.
Clinical Trials Related to Percocet (Oxycodone / Acetaminophen)
Comparison of Tramacet Versus Percocet in Post Surgical Patients [Not yet recruiting]
Opioid naive patients are randomized to receive either TRAMACET or PERCOCET at the time of
discharge following mild to moderate pain risk surgery. The following will be assessed: 1)
Brief pain inventory (BPI) for the month. 2) Post operative pain management satisfaction. 3)
Whether they sought any repeat opioid prescription. 4) Whether they intend to seek repeat
opioid prescription. It is expected that both groups will have similar pain outcomes but
those patients in the Percocet group will be more likely to seek a second prescription.
Post-tonsillectomy Pain Control in Adults [Not yet recruiting]
This is a randomized prospective study to determine the optimal postoperative pain
medication regimen for adults (18 years old and older) undergoing tonsillectomy with or
without adenoidectomy for chronic tonsillitis and/or snoring and/or obstructive sleep apnea.
All participants will undergo the same tonsillectomy surgical technique (with or without
adenoidectomy) under general anesthesia and be randomized to one of three postoperative pain
control regimens (all of which are commonly used pain medications for post-tonsillectomy
pain):
1. Norco (Hydrocodone and Acetaminophen)
2. Percocet (Oxycodone and Acetaminophen)
3. Dilaudid and Tylenol (Acetaminophen)
Participants will be discharged home the day of surgery and will be sent home with
questionnaires to assess their daily pain level, oral intake, amount of nausea/vomiting, and
amount of pain medications taken for the 14 days following their surgery. Data will be
collected and analyzed to determine if there is a difference in pain levels or oral intake
or nausea/vomiting in the different pain regimen groups. Secondary endpoints will include
weight change from preoperative weight to weight at 2-3 weeks after surgery in addition to
postoperative complications including visits to the Emergency Department and
post-tonsillectomy bleed rates.
Participants will be seen 1-2 weeks following their surgery in the ENT (Ear, Nose and
Throat) clinic per normal postoperative protocol and will not require any specific clinic
visits related to this study.
PK and Safety Study of XARTEMIS� XR (7.5 mg Oxycodone HCl/325 mg APAP) in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain [Recruiting]
Phase 4, multicenter, open-label, multiple-dose study of the pharmacokinetics (PK) and
safety of XARTEMIS XR in postsurgical adolescent subjects aged 12 to 17 years with moderate
to severe acute pain. The study will assess the safety of administering multiple doses of
XARTEMIS XR in this population.
A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain [Recruiting]
The purpose of this study is to explore the clinical characteristics oral MNK155 and Norco®
7. 5mg/325mg when used for the treatment of moderate to severe post operative pain.
Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Completed]
This study aims to determine whether the hydrocodone and acetaminophen exposures following
oral dosing of Vycavert are comparable to those following oral dosing of Norco.
Reports of Suspected Percocet (Oxycodone / Acetaminophen) Side Effects
Drug Ineffective (53),
Pain (41),
Drug Hypersensitivity (32),
Anxiety (26),
Drug Dependence (21),
Substance Abuse (20),
Malaise (20),
Drug Withdrawal Syndrome (20),
Memory Impairment (20),
Product Quality Issue (18), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 12 ratings/reviews, Percocet has an overall score of 5.75. The effectiveness score is 8.17 and the side effect score is 6.33. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Percocet review by 31 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | pain |
| Dosage & duration: | | 325mg taken 1 tab every 4 hours as needed for pain for the period of 2 days |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | The pill was very effective and i felt the relief from the pain considerably right after taking the pill |
| Side effects: | | This medication does cause drowsiness, and dizziness as it says on the label. Rest is a must while taking this medication. Its better if you do not drive and perform intensive activities right after taking this medication. It is a very strong medication and since I have a petite physique, I did think that the dose was a bit too high for me. I felt very light headed and drowsy after taking th epill but i must say the pill does do its job. |
| Comments: | | The pill was prescribed to me for recovering from pain after my wisdom teeth were extracted. It was a very effective pain killer. All of my wisdom teeth were extracted the same day and I was in excruciating pain once the anesthetic wore off. As soon as I took thi smedication, I felt great relief. I was prescribed only 5 pills but I felt much better after taking only 3, 1 every 4 hours. |
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| | Percocet review by 25 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Moderate Side Effects | | |
Treatment Info |
| Condition / reason: | | ACL surgery |
| Dosage & duration: | | 500 (dosage frequency: every 5 hours) for the period of 6 weeks |
| Other conditions: | | N/A |
| Other drugs taken: | | N/A | | |
Reported Results |
| Benefits: | | The benefits of percocet were that it did take away my pain from my knee surgery, but I felt it needed to be stronger toward the end of the 5 hours. |
| Side effects: | | My side effects were mild itching. It drove me crazy, I had to switch to a differnt pain medication. |
| Comments: | | I had to take 2 pills every 5 hours. |
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| | Percocet review by 65 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | foot surgery |
| Dosage & duration: | | 50 m (dosage frequency: once every 4-6 hours for pain) for the period of one day |
| Other conditions: | | none |
| Other drugs taken: | | none | | |
Reported Results |
| Benefits: | | I waited about 12 hours after surgery - till incision began to hurt - before I took the drug. It might have been move effective if I had taken it before pain started. As it was, it took about two hours to get relief. |
| Side effects: | | Main effects were nausea, light headedness and room spining. |
| Comments: | | Drug prescribed for pain after surgery. If I had taken drug a few hours after surgery, anticipating the incision might be become painful, the outcome might have been different. Because I waited, I took one pill about 9 p.m., another about 11 p.m. and it was not until midnight that I got any relief. The next morning, I was nauseous and and light headed. I don't take any medication, so the impact of the drug in my system was noticeable and not pleasant. On second day after surgery, I took a couple of Advil. After that, nothing. |
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Page last updated: 2017-09-28
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