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Percocet (Oxycodone Hydrochloride / Acetaminophen) - Summary




Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death.  Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.



Each tablet, for oral administration, contains oxycodone hydrochloride and acetaminophen.

PERCOCET is indicated for the relief of moderate to moderately severe pain.

See all Percocet indications & dosage >>


Media Articles Related to Percocet (Oxycodone / Acetaminophen)

Inflammatory Back Pain Linked With Bone Loss (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2015.09.26]
(MedPage Today) -- Anti-TNF and NSAID therapies have protective effects

EMA Panel Backs Fentanyl Patch Ionsys for Acute Postop Pain
Source: Medscape Anesthesiology Headlines [2015.09.25]
Ionsys is a needle-free, patient-controlled, pre-programmed fentanyl delivery system for use in patients requiring short-term opioid analgesia after surgery.
International Approvals

Managing Pain in Patients With CVD
Source: Medscape Pharmacists Headlines [2015.09.25]
Are NSAIDs ever an option for pain management in patients with cardiovascular disease?
Medscape Internal Medicine

New drug trial could help relieve the pain of diabetes
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.09.25]
UK patients with diabetic neuropathy are being recruited for a phase II clinical trial which will evaluate the safety, tolerability and efficacy of a novel class of analgesicThe trial will be...

Make the Diagnosis: Acute Abdominal Pain
Source: MedPage Today Gastroenterology [2015.09.25]
(MedPage Today) -- Case Findings: A male in his early 30s is admitted to the hospital with a life-threatening diagnosis, and triglycerides greater than 4000 mg/dL. Emergent plasmapheresis was initiated, and has been repeated. The patient remained in the ICU with sepsis. What is your diagnosis?

more news >>

Published Studies Related to Percocet (Oxycodone / Acetaminophen)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.

Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. [2007.07]
BACKGROUND: Oral opioid formulations contribute to postoperative analgesia. In this study, we evaluated the perioperative application of oral controlled-release oxycodone to reduce postoperative IV morphine consumption and opioid side effects after lumbar discectomy... CONCLUSIONS: Perioperative oral controlled-release oxycodone reduces postoperative IV morphine consumption after lumbar discectomy while providing good analgesia with fewer side effects compared with placebo.

Efficacy and tolerability of once-daily OROS hydromorphone and twice-daily extended-release oxycodone in patients with chronic, moderate to severe osteoarthritis pain: results of a 6-week, randomized, open-label, noninferiority analysis. [2007.05]
OBJECTIVE: This study compared the efficacy and tolerability of a once-daily controlled-release formulation of hydromorphone (OROS) hydromorphone, Janssen-Cilag, Beerse, Belgium) and twice-daily extended-release (ER) oxycodone in patients with chronic, moderate to severe osteoarthritis (OA) pain. OROS hydromorphone is currently available only in Europe... CONCLUSIONS: Once-daily OROS hydromorphone and twice-daily ER oxycodone provided similar pain relief in these patients with OA of the knee or hip. The tolerability profiles of the 2 agents were similar.

more studies >>

Clinical Trials Related to Percocet (Oxycodone / Acetaminophen)

Comparison of Tramacet Versus Percocet in Post Surgical Patients [Not yet recruiting]
Opioid naive patients are randomized to receive either TRAMACET or PERCOCET at the time of discharge following mild to moderate pain risk surgery. The following will be assessed: 1) Brief pain inventory (BPI) for the month. 2) Post operative pain management satisfaction. 3) Whether they sought any repeat opioid prescription. 4) Whether they intend to seek repeat opioid prescription. It is expected that both groups will have similar pain outcomes but those patients in the Percocet group will be more likely to seek a second prescription.

Post-tonsillectomy Pain Control in Adults [Not yet recruiting]
This is a randomized prospective study to determine the optimal postoperative pain medication regimen for adults (18 years old and older) undergoing tonsillectomy with or without adenoidectomy for chronic tonsillitis and/or snoring and/or obstructive sleep apnea. All participants will undergo the same tonsillectomy surgical technique (with or without adenoidectomy) under general anesthesia and be randomized to one of three postoperative pain control regimens (all of which are commonly used pain medications for post-tonsillectomy pain): 1. Norco (Hydrocodone and Acetaminophen) 2. Percocet (Oxycodone and Acetaminophen) 3. Dilaudid and Tylenol (Acetaminophen) Participants will be discharged home the day of surgery and will be sent home with questionnaires to assess their daily pain level, oral intake, amount of nausea/vomiting, and amount of pain medications taken for the 14 days following their surgery. Data will be collected and analyzed to determine if there is a difference in pain levels or oral intake or nausea/vomiting in the different pain regimen groups. Secondary endpoints will include weight change from preoperative weight to weight at 2-3 weeks after surgery in addition to postoperative complications including visits to the Emergency Department and post-tonsillectomy bleed rates. Participants will be seen 1-2 weeks following their surgery in the ENT (Ear, Nose and Throat) clinic per normal postoperative protocol and will not require any specific clinic visits related to this study.

PK and Safety Study of XARTEMIS� XR (7.5 mg Oxycodone HCl/325 mg APAP) in Postsurgical Adolescent Subjects With Moderate to Severe Acute Pain [Recruiting]
Phase 4, multicenter, open-label, multiple-dose study of the pharmacokinetics (PK) and safety of XARTEMIS XR in postsurgical adolescent subjects aged 12 to 17 years with moderate to severe acute pain. The study will assess the safety of administering multiple doses of XARTEMIS XR in this population.

A Randomized, Open Label, Prospective Study to Explore the Clinical Characteristics of Oral MNK155 and Norco 7.5mg/325 When Used for the Treatment of Moderate to Severe Post Operative Pain [Recruiting]
The purpose of this study is to explore the clinical characteristics oral MNK155 and Norco 7. 5mg/325mg when used for the treatment of moderate to severe post operative pain.

Pharmacokinetics and Bioequivalence of Vycavert (10 mg Hydrocodone Bitartrate/325 mg Acetaminophen) Compared to the Reference Drug Norco [Completed]
This study aims to determine whether the hydrocodone and acetaminophen exposures following oral dosing of Vycavert are comparable to those following oral dosing of Norco.

more trials >>

Reports of Suspected Percocet (Oxycodone / Acetaminophen) Side Effects

Drug Ineffective (53)Pain (41)Drug Hypersensitivity (32)Anxiety (26)Drug Dependence (21)Substance Abuse (20)Malaise (20)Drug Withdrawal Syndrome (20)Memory Impairment (20)Product Quality Issue (18)more >>


Based on a total of 12 ratings/reviews, Percocet has an overall score of 5.75. The effectiveness score is 8.17 and the side effect score is 6.33. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Percocet review by 31 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   pain
Dosage & duration:   325mg taken 1 tab every 4 hours as needed for pain for the period of 2 days
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The pill was very effective and i felt the relief from the pain considerably right after taking the pill
Side effects:   This medication does cause drowsiness, and dizziness as it says on the label. Rest is a must while taking this medication. Its better if you do not drive and perform intensive activities right after taking this medication. It is a very strong medication and since I have a petite physique, I did think that the dose was a bit too high for me. I felt very light headed and drowsy after taking th epill but i must say the pill does do its job.
Comments:   The pill was prescribed to me for recovering from pain after my wisdom teeth were extracted. It was a very effective pain killer. All of my wisdom teeth were extracted the same day and I was in excruciating pain once the anesthetic wore off. As soon as I took thi smedication, I felt great relief. I was prescribed only 5 pills but I felt much better after taking only 3, 1 every 4 hours.


Percocet review by 25 year old female patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   ACL surgery
Dosage & duration:   500 (dosage frequency: every 5 hours) for the period of 6 weeks
Other conditions:   N/A
Other drugs taken:   N/A
Reported Results
Benefits:   The benefits of percocet were that it did take away my pain from my knee surgery, but I felt it needed to be stronger toward the end of the 5 hours.
Side effects:   My side effects were mild itching. It drove me crazy, I had to switch to a differnt pain medication.
Comments:   I had to take 2 pills every 5 hours.


Percocet review by 65 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   foot surgery
Dosage & duration:   50 m (dosage frequency: once every 4-6 hours for pain) for the period of one day
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   I waited about 12 hours after surgery - till incision began to hurt - before I took the drug. It might have been move effective if I had taken it before pain started. As it was, it took about two hours to get relief.
Side effects:   Main effects were nausea, light headedness and room spining.
Comments:   Drug prescribed for pain after surgery. If I had taken drug a few hours after surgery, anticipating the incision might be become painful, the outcome might have been different. Because I waited, I took one pill about 9 p.m., another about 11 p.m. and it was not until midnight that I got any relief. The next morning, I was nauseous and and light headed. I don't take any medication, so the impact of the drug in my system was noticeable and not pleasant. On second day after surgery, I took a couple of Advil. After that, nothing.

See all Percocet reviews / ratings >>

Page last updated: 2015-09-26

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