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Percocet (Oxycodone Hydrochloride / Acetaminophen) - Summary



The principal ingredient, oxycodone, is a semisynthetic opioid analgesic with multiple actions qualitatively similar to those of morphine. Acetaminophen is a non-opiate, non-salicylate analgesic and antipyretic.

PERCOCET is indicated for the relief of moderate to moderately severe pain.

See all Percocet indications & dosage >>


Media Articles Related to Percocet (Oxycodone / Acetaminophen)

Coordination of Care Matters Most to Patients With Chronic Pain
Source: Medscape NeurologyHeadlines [2015.03.27]
A survey shows patients rank coordination of chronic pain management above the relationship with their healthcare provider, and outcomes correlate with the quality of coordination.
Medscape Medical News

Study identifies low back pain risk factors
Source: Bones / Orthopedics News From Medical News Today [2015.03.27]
Counseling at-risk patients may prevent and minimize painNew research presented at the 2015 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS) identifies nicotine dependence...

New technique paints tissue samples with light
Source: Breast Cancer News From Medical News Today [2015.03.27]
One infrared scan can give pathologists a window into the structures and molecules inside tissues and cells, enabling fast and broad diagnostic assessments, thanks to an imaging technique developed...

Researchers discover a key mechanism of chronic inflammatory pain that could reduce drug doses
Source: Neurology / Neuroscience News From Medical News Today [2015.03.27]
A study led by Professor Lucía Hipólito, from the Department of Pharmacy and Pharmaceutical Technology of the University of Valencia, has revealed a new mechanism to treat chronic inflammatory...

Intradiscal Biacuplasty Bests Standard Back Pain Therapy
Source: Medscape NeurologyHeadlines [2015.03.26]
The minimally invasive radiofrequency therapy shows significantly higher rates of pain relief compared with conventional therapy approaches after 6 months in a randomized study.
Medscape Medical News

more news >>

Published Studies Related to Percocet (Oxycodone / Acetaminophen)

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

Comparison of the efficacy and safety of dual-opioid treatment with morphine plus oxycodone versus oxycodone/acetaminophen for moderate to severe acute pain after total knee arthroplasty. [2013]
oxycodone/acetaminophen and fixed low-dose morphine/oxycodone... CONCLUSIONS: Flexible dose morphine/oxycodone was superior to low-dose

Oxycodone/acetaminophen at low dosage: an alternative pain treatment for patients with rheumatoid arthritis. [2010.01]
OBJECTIVES: To assess efficacy and safety of the association oxycodone/acetaminophen (oxycodone/acetaminophen) for pain treatment and disability improvement in patients with rheumatoid arthritis (RA)... CONCLUSION: Oxycodone/acetaminophen at low dosages for the treatment of chronic pain in RA patients can be a good alternative to non-steroidal antiinflammatory drugs (NSAIDs), allowing the reduction of their consumption, while keeping RA therapy stable.

Postoperative intravenous morphine consumption, pain scores, and side effects with perioperative oral controlled-release oxycodone after lumbar discectomy. [2007.07]
BACKGROUND: Oral opioid formulations contribute to postoperative analgesia. In this study, we evaluated the perioperative application of oral controlled-release oxycodone to reduce postoperative IV morphine consumption and opioid side effects after lumbar discectomy... CONCLUSIONS: Perioperative oral controlled-release oxycodone reduces postoperative IV morphine consumption after lumbar discectomy while providing good analgesia with fewer side effects compared with placebo.

Efficacy and tolerability of once-daily OROS hydromorphone and twice-daily extended-release oxycodone in patients with chronic, moderate to severe osteoarthritis pain: results of a 6-week, randomized, open-label, noninferiority analysis. [2007.05]
OBJECTIVE: This study compared the efficacy and tolerability of a once-daily controlled-release formulation of hydromorphone (OROS) hydromorphone, Janssen-Cilag, Beerse, Belgium) and twice-daily extended-release (ER) oxycodone in patients with chronic, moderate to severe osteoarthritis (OA) pain. OROS hydromorphone is currently available only in Europe... CONCLUSIONS: Once-daily OROS hydromorphone and twice-daily ER oxycodone provided similar pain relief in these patients with OA of the knee or hip. The tolerability profiles of the 2 agents were similar.

more studies >>

Clinical Trials Related to Percocet (Oxycodone / Acetaminophen)

A Study Comparing Oxycodone to Oxycodone/Naloxone in Moderate to Severe, Chronic Cancer Pain [Recruiting]

Oxycodone-Naloxone Prolonged Release Tablets in Relieving Opioid-Related Constipation [Active, not recruiting]

Oxycodone-Naloxone in Relieving Opioid-Related Constipation [Active, not recruiting]
The primary objective of this study is to demonstrate that subjects with moderate to severe non-malignant pain taking oxycodone/naloxone prolonged release tablets have improvement in symptoms of constipation compared to subjects taking oxycodone prolonged release tablets alone.

Morphine vs. Oxycodone for Postoperative Pain Management [Recruiting]
The purpose of this study is to determine whether oxycodone provides better analgesia compared to morphine after laparoscopic hysterectomy or myomectomy.

Efficacy and Safety of Fentanyl Buccal Tablets Compared With Oxycodone for the Management of Break Through Pain [Recruiting]
Evaluate the efficacy of treatment with Fentanyl Buccal Tablets (FBT) compared with immediate release oxycodone in alleviating breakthrough pain in opioid tolerant patients with chronic pain.

more trials >>

Reports of Suspected Percocet (Oxycodone / Acetaminophen) Side Effects

Drug Ineffective (53)Pain (41)Drug Hypersensitivity (32)Anxiety (26)Drug Dependence (21)Substance Abuse (20)Malaise (20)Drug Withdrawal Syndrome (20)Memory Impairment (20)Product Quality Issue (18)more >>


Based on a total of 12 ratings/reviews, Percocet has an overall score of 5.75. The effectiveness score is 8.17 and the side effect score is 6.33. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Percocet review by 31 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   pain
Dosage & duration:   325mg taken 1 tab every 4 hours as needed for pain for the period of 2 days
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The pill was very effective and i felt the relief from the pain considerably right after taking the pill
Side effects:   This medication does cause drowsiness, and dizziness as it says on the label. Rest is a must while taking this medication. Its better if you do not drive and perform intensive activities right after taking this medication. It is a very strong medication and since I have a petite physique, I did think that the dose was a bit too high for me. I felt very light headed and drowsy after taking th epill but i must say the pill does do its job.
Comments:   The pill was prescribed to me for recovering from pain after my wisdom teeth were extracted. It was a very effective pain killer. All of my wisdom teeth were extracted the same day and I was in excruciating pain once the anesthetic wore off. As soon as I took thi smedication, I felt great relief. I was prescribed only 5 pills but I felt much better after taking only 3, 1 every 4 hours.


Percocet review by 25 year old female patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   ACL surgery
Dosage & duration:   500 (dosage frequency: every 5 hours) for the period of 6 weeks
Other conditions:   N/A
Other drugs taken:   N/A
Reported Results
Benefits:   The benefits of percocet were that it did take away my pain from my knee surgery, but I felt it needed to be stronger toward the end of the 5 hours.
Side effects:   My side effects were mild itching. It drove me crazy, I had to switch to a differnt pain medication.
Comments:   I had to take 2 pills every 5 hours.


Percocet review by 65 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   foot surgery
Dosage & duration:   50 m (dosage frequency: once every 4-6 hours for pain) for the period of one day
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   I waited about 12 hours after surgery - till incision began to hurt - before I took the drug. It might have been move effective if I had taken it before pain started. As it was, it took about two hours to get relief.
Side effects:   Main effects were nausea, light headedness and room spining.
Comments:   Drug prescribed for pain after surgery. If I had taken drug a few hours after surgery, anticipating the incision might be become painful, the outcome might have been different. Because I waited, I took one pill about 9 p.m., another about 11 p.m. and it was not until midnight that I got any relief. The next morning, I was nauseous and and light headed. I don't take any medication, so the impact of the drug in my system was noticeable and not pleasant. On second day after surgery, I took a couple of Advil. After that, nothing.

See all Percocet reviews / ratings >>

Page last updated: 2015-03-27

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