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Pentazocine and Naloxone (Pentazocine Hydrochloride / Naloxone Hydrochloride) - Summary

 
 



SUMMARY

Pentazocine and naloxone hydrochlorides tablets USP contain pentazocine hydrochloride USP, equivalent to 50 mg base, a member of the benzazocine series (also known as the benzomorphan series), and naloxone hydrochloride USP, equivalent to 0.5 mg base. Pentazocine and naloxone hydrochlorides tablets are an analgesic for oral administration.

Pentazocine and naloxone hydrochlorides tablets are intended for oral use only. Severe, potentially lethal, reactions may result from misuse of pentazocine and naloxone hydrochlorides tablets by injection either alone or in combination with other substances. (See DRUG ABUSE AND DEPENDENCE section.)

Pentazocine and naloxone hydrochlorides tablets are indicated for the relief of moderate to severe pain.

Pentazocine and naloxone hydrochlorides tablets are indicated for oral use only.


See all Pentazocine and Naloxone indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pentazocine and Naloxone (Pentazocine / Naloxone)

Medical News Today: Complex regional pain syndrome: Watching others causes pain
Source: Featured Health News from Medical News Today [2016.12.02]
For patients with complex regional pain syndrome, simply watching someone else move can cause intense pain. An MRI scan study delves into the neuroscience.

Complex regional pain syndrome: Watching others causes pain
Source: Pain / Anesthetics News From Medical News Today [2016.12.02]
For patients with complex regional pain syndrome, simply watching someone else move can cause intense pain. An MRI scan study delves into the neuroscience.

Specially Designed Video Game Might Ease 'Phantom Limb' Pain
Source: MedicineNet Chronic Pain Specialty [2016.12.02]
Title: Specially Designed Video Game Might Ease 'Phantom Limb' Pain
Category: Health News
Created: 12/1/2016 12:00:00 AM
Last Editorial Review: 12/2/2016 12:00:00 AM

Should Pain Scores No Longer Be Vital?
Source: Medscape Anesthesiology Headlines [2016.12.01]
Asking patients how severe their pain is on a scale of 1 to 10 isn't vital to pain management, the AAFP says. What do you think?
Medscape Reader Polls

Can VR Games Soothe Phantom Limb Pain?
Source: MedPage Today Neurology [2016.12.01]
(MedPage Today) -- Pain reduced among arm amputees

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Published Studies Related to Pentazocine and Naloxone (Pentazocine / Naloxone)

Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice. [2010.09.01]
Mechanical allodynia is a major complication in diabetic mellitus. Peripheral sigma(1) receptors were shown to be involved in nociceptive perception... This attenuation may be, in part, due to the normalization of increased peripheral NO contents in the hindpaw of diabetic mice.

Hazards of pentazocine for neonatal analgesia: a single-centre experience over 10 years. [2008.09]
BACKGROUND: In developing countries, neonatal analgesia for surgical procedures is a major challenge where postoperative care is inadequate. AIM: To report experience of pentazocine for neonatal surgery in a Nigerian tertiary hospital... CONCLUSION: The use of pentazocine in neonates was associated with high morbidity and mortality. Caution is required when using pentazocine for neonatal analgesia where post-operative respiratory support is insufficient.

Improvement of memory impairment by (+)- and (-)-pentazocine via sigma, but not kappa opioid receptors. [2005.09.28]
(+/-)-Pentazocine is widely used clinically to treat mild to moderate pain as a racemic compound. Although it is known that (-)-pentazocine acts as a kappa opioid receptor agonist to exhibit analgesic actions and (+)-pentazocine acts as a sigma receptor agonist without analgesic effects, their combined effect on memory has not been investigated in detail.

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Clinical Trials Related to Pentazocine and Naloxone (Pentazocine / Naloxone)

Effects of Pentazocine Versus Lorazepam on Manic Symptoms [Completed]
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study. We will examine whether pentazocine, an agent with kappa-opiate activity, decreases manic symptoms.

Effects of Pentazocine on Manic Symptoms [Completed]
The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.

Effects of a Kappa Agonist on Hot Flashes in Menopausal Women [Completed]

The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation [Completed]
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain. The use of appropriate postoperative analgesia in patients with thoracolumbar surgery is beneficial to postoperative recovery. Infusions of local anaesthetic via multilumen catheters that deliver directly to wound sites have been used for postoperative analgesia in procedures. Reducing the morbidity from both pain and nausea will make the mode of analgesia a better tolerated and more palatable option for patients. The aim of this study is to examine the effects of using local anaesthetic infusion catheters following posterior thoracolumbar surgery, and compares the outcomes of patients managed using intravenous analgesia pump infusion of systemic opioids.

The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial [Not yet recruiting]
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.

more trials >>


Page last updated: 2016-12-02

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