Pentazocine and naloxone hydrochlorides tablets USP contain pentazocine hydrochloride USP, equivalent to 50 mg base, a member of the benzazocine series (also known as the benzomorphan series), and naloxone hydrochloride USP, equivalent to 0.5 mg base. Pentazocine and naloxone hydrochlorides tablets are an analgesic for oral administration.
|Pentazocine and naloxone hydrochlorides tablets are intended for oral use only. Severe, potentially lethal, reactions may result from misuse of pentazocine and naloxone hydrochlorides tablets by injection either alone or in combination with other substances. (See DRUG ABUSE AND DEPENDENCE section.)|
Pentazocine and naloxone hydrochlorides tablets are indicated for the relief of moderate to severe pain.
Pentazocine and naloxone hydrochlorides tablets are indicated for oral use only.
Media Articles Related to Pentazocine and Naloxone (Pentazocine / Naloxone)
Early Imaging Unhelpful in Older Adults With New Back Pain
Source: Medscape NeurologyHeadlines [2015.03.20]
A new study provides more evidence that early routine imaging for new-onset back pain in the elderly is costly and provides no benefit.
Medscape Medical News
Early imaging for back pain in older adults not associated with better outcomes
Source: Medical Devices / Diagnostics News From Medical News Today [2015.03.20]
Older adults who had spine imaging within 6 weeks of a new primary care visit for back pain had pain and disability over the following year that was not different from similar patients who did not...
Spinal cord neurons that control pain and itch
Source: Neurology / Neuroscience News From Medical News Today [2015.03.20]
The spinal cord transmits pain signals to the brain, where they are consciously perceived.
Stepped-Care Approach to Chronic Pain Improves Function
Source: Medscape Nurses Headlines [2015.03.19]
A two-step program combining analgesics, self-management strategies, and cognitive-behavioral therapy yields lasting improvement in chronic pain and function in a trial of US veterans.
Medscape Medical News
Minimally invasive spinal fusion: Less pain, faster recovery, smaller scar
Source: Bones / Orthopedics News From Medical News Today [2015.03.19]
A minimally invasive spinal fusion back surgery results in less blood loss, less postoperative pain, smaller incisions, a shorter hospital stay and faster recovery and return to work.
Published Studies Related to Pentazocine and Naloxone (Pentazocine / Naloxone)
Effect of acute topical application of +-pentazocine on the mechanical allodynia in diabetic mice. [2010.09.01]
Mechanical allodynia is a major complication in diabetic mellitus. Peripheral sigma(1) receptors were shown to be involved in nociceptive perception... This attenuation may be, in part, due to the normalization of increased peripheral NO contents in the hindpaw of diabetic mice.
Hazards of pentazocine for neonatal analgesia: a single-centre experience over 10 years. [2008.09]
BACKGROUND: In developing countries, neonatal analgesia for surgical procedures is a major challenge where postoperative care is inadequate. AIM: To report experience of pentazocine for neonatal surgery in a Nigerian tertiary hospital... CONCLUSION: The use of pentazocine in neonates was associated with high morbidity and mortality. Caution is required when using pentazocine for neonatal analgesia where post-operative respiratory support is insufficient.
Improvement of memory impairment by (+)- and (-)-pentazocine via sigma, but not kappa opioid receptors. [2005.09.28]
(+/-)-Pentazocine is widely used clinically to treat mild to moderate pain as a racemic compound. Although it is known that (-)-pentazocine acts as a kappa opioid receptor agonist to exhibit analgesic actions and (+)-pentazocine acts as a sigma receptor agonist without analgesic effects, their combined effect on memory has not been investigated in detail.
Clinical Trials Related to Pentazocine and Naloxone (Pentazocine / Naloxone)
Effects of Pentazocine Versus Lorazepam or Placebo on Manic Symptoms [Recruiting]
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals.
To follow up these initial findings, we plan to conduct a larger, more rigorous,
double-blind study. We will examine whether pentazocine, an agent with kappa-opiate
activity, decreases manic symptoms.
Effects of Pentazocine on Manic Symptoms [Active, not recruiting]
The opiate neurotransmitter system is thought to be involved in many abnormal mood states.
Some researchers have suggested that changes in this system may trigger the switch to/from
manic and depressive states in bipolar disorder. One problem with most of the currently
available opiate medications is that they can produce addiction/dependence. A particular
kind of opiate medication known as kappa-opiates may be able to produce changes in this
system with much less risk of addiction. This study looks at Talwin (a combination of
pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The
study will examine whether two doses of Talwin affect manic symptoms in people who have been
admitted to the hospital. This study will give more information about the involvement of the
opiate system in bipolar disorder, and give important information for use in developing new
The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial [Not yet recruiting]
To explore the feasibility of different doses of etomidate admixed with propofol in induced
abortion: a randomized, double blind controlled trial.
Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty [Recruiting]
Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may
delay recovery. There are multimodal postoperative pain management after TKA, including
intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular
infiltration with local anesthetics. All of these treatments may lead to side effects such
as nausea, headache, hypotension, urinary retention, partial motor block and infection of
the knee. Therefore the investigators will compare three methods of postoperative analgesic
after TKA by their efficiency and complication.
Comparison of Two Kinds of Postoperative Analgesia After Amputation [Recruiting]
Pain after amputation is a significant problem among amputees. Phantom limb pain may appear
in up to 85% of patients and is usually resistant to a wide variety of treatments. It is
believed that regional anesthesia, by preventing the establishment of central sensitization,
may play a role in reducing the incidence of acute and chronic pain. Therefore the
investigators will compare two methods of postoperative analgesic after after amputation by
their efficiency and complication.