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Pentazocine and Acetaminophen (Pentazocine Hydrochloride / Acetaminophen) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Clinical experience with pentazocine and acetaminophen tablets has been insufficient to define all possible adverse reactions with this combination. However, reactions reported after oral administration of pentazocine in 50 mg dosage include the following:

Cardiovascular: hypertension, hypotension, circulatory depression, tachycardia. 

Respiratory: rarely respiratory depression,

Acute CNS Manifestations: Hallucinations (usually visual), disorientation, and confusion

Other CNS effects: grand mal convulsions, increase in intracranial pressure, dizziness, lightheadedness, hallucinations, sedation, euphoria, headache, confusion, disorientation; infrequently weakness, disturbed dreams, insomnia, syncope, and depression; and rarely tremor, irritability, excitement, tinnitus.

Autonomic: sweating; infrequently flushing; and rarely chills.

Gastrointestinal:  nausea, vomiting, constipation; diarrhea, anorexia, dry mouth, Biliary tract spasm, and rarely abdominal distress.

Allergic: edema of the face, anaphylactic shock, dermatitis including pruritus, flushed skin including plethora, infrequently rash; and rarely urticaria.

Ophthalmic: visual blurring and focusing difficulty, miosis.

Hematologic: depression of white blood cells (especially granulocytes) with rare cases of agranulocytosis, which is usually reversible, moderate transient eosinophilia.

Dependence and Withdrawal Symptoms: (See WARNINGS, PRECAUTIONS  , and DRUG ABUSE AND DEPENDENCE   Sections).

Other:  urinary retention, paresthesia, serious skin reactions, including erythema multiforme, Stevens-Johnson Syndrome, toxic epidermal necrolysis, and alterations in rate or strength of uterine contractions during labor.

A few cases of hypersensitivity to acetaminophen have been reported, as manifested by anaphylaxis, angioneurotic edema, thrombocytopenic purpura, skin rashes, and rarely hemolytic anemia and agranulocytosis.  Occasionally individuals respond to ordinary doses with nausea and vomiting and diarrhea.

Drug label data at the top of this Page last updated: 2014-03-14

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