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Pentazocine and Acetaminophen (Pentazocine Hydrochloride / Acetaminophen) - Summary

 
 



BOXED WARNING
Hepatotoxicity
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

 

SUMMARY

Pentazocine hydrochloride and acetaminophen tablets are a combination of pentazocine hydrochloride USP, equivalent to 25 mg base and acetaminophen USP, 650 mg. Pentazocine is a member of the benzazocine series (also known as the benzomorphan series).

Pentazocine hydrochloride and acetaminophen tablets are indicated for the relief of mild to moderate pain.


See all Pentazocine and Acetaminophen indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

A 19-Year-Old Woman With Abdominal Pain and Diarrhea
Source: Medscape Medical Students Headlines [2017.09.22]
A 19-year-old woman presents due to fevers, nausea, severe abdominal pain, and watery diarrhea. The symptoms have been on-and-off over the past few months. What treatment is indicated?
Osmosis

Brain Imaging Cannot Prove or Disprove Chronic Pain
Source: Medscape Anesthesiology Headlines [2017.09.21]
Brain imaging to support or dispute a claim of chronic pain is unwarranted, according to a consensus statement from the International Association for the Study of Pain (IASP).
Reuters Health Information

Patient Action: As Means and End for Chronic Pain Care
Source: Medscape Anesthesiology Headlines [2017.09.21]
The authors explore the importance of patient action in the self-management of chronic pain.
Pain

Vagal Nerve Stimulation Stops Episodic Cluster Headache Pain
Source: Medscape Allergy & Clinical Immunology Headlines [2017.09.20]
Noninvasive vagal nerve stimulation provides complete pain relief for patients with episodic cluster headaches -- but not chronic cluster headaches, suggest results from the ACT2 trial.
Medscape Medical News

Poor Sleep Associated With Higher Risk of Chronic Pain
Source: Medscape Anesthesiology Headlines [2017.09.20]
People who sleep poorly may be more likely to develop a chronic pain condition and have worse physical health, a study from the UK suggests.
Reuters Health Information

more news >>

Published Studies Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine] [2007.11]
BACKGROUND: The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement... CONCLUSIONS: The incidence of PONV in propofol-anesthetized patients receiving pentazocine as opioid supplement is not different from that in patients receiving fentanyl.

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Clinical Trials Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

Effects of Pentazocine Versus Lorazepam on Manic Symptoms [Completed]
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study. We will examine whether pentazocine, an agent with kappa-opiate activity, decreases manic symptoms.

Effects of Pentazocine on Manic Symptoms [Completed]
The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.

Effects of a Kappa Agonist on Hot Flashes in Menopausal Women [Completed]

The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation [Completed]
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain. The use of appropriate postoperative analgesia in patients with thoracolumbar surgery is beneficial to postoperative recovery. Infusions of local anaesthetic via multilumen catheters that deliver directly to wound sites have been used for postoperative analgesia in procedures. Reducing the morbidity from both pain and nausea will make the mode of analgesia a better tolerated and more palatable option for patients. The aim of this study is to examine the effects of using local anaesthetic infusion catheters following posterior thoracolumbar surgery, and compares the outcomes of patients managed using intravenous analgesia pump infusion of systemic opioids.

The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial [Not yet recruiting]
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.

more trials >>


Page last updated: 2017-09-22

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