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Pentazocine and Acetaminophen (Pentazocine Hydrochloride / Acetaminophen) - Summary

 
 



BOXED WARNING
Hepatotoxicity
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

 

SUMMARY

Pentazocine hydrochloride and acetaminophen tablets are a combination of pentazocine hydrochloride USP, equivalent to 25 mg base and acetaminophen USP, 650 mg. Pentazocine is a member of the benzazocine series (also known as the benzomorphan series).

Pentazocine hydrochloride and acetaminophen tablets are indicated for the relief of mild to moderate pain.


See all Pentazocine and Acetaminophen indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

Lidocaine Eases Pain, Improves Sex in Breast Cancer Patients
Source: Medscape Hematology-Oncology Headlines [2015.07.31]
Topical lidocaine makes intercourse more comfortable in postmenopausal breast cancer patients with severe dyspareunia.
Medscape Medical News

Vaginal Pain
Source: MedicineNet Itch Specialty [2015.07.31]
Title: Vaginal Pain
Category: Diseases and Conditions
Created: 4/17/2009 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

Health Tip: Easing Neck Pain at Night
Source: MedicineNet Neck Pain Specialty [2015.07.31]
Title: Health Tip: Easing Neck Pain at Night
Category: Health News
Created: 7/31/2015 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

Knee Replacement May Ease Pain for Rheumatoid Arthritis Patients
Source: MedicineNet Osteoarthritis Specialty [2015.07.31]
Title: Knee Replacement May Ease Pain for Rheumatoid Arthritis Patients
Category: Health News
Created: 7/30/2015 12:00:00 AM
Last Editorial Review: 7/31/2015 12:00:00 AM

Persistent severe back pain could signify rare spine infection: new IDSA guideline
Source: Bones / Orthopedics News From Medical News Today [2015.07.30]
Patients with back pain that doesn't go away despite therapy may have a spine infection that could lead to paralysis or death if not diagnosed and treated correctly, note the first U.S.

more news >>

Published Studies Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine] [2007.11]
BACKGROUND: The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement... CONCLUSIONS: The incidence of PONV in propofol-anesthetized patients receiving pentazocine as opioid supplement is not different from that in patients receiving fentanyl.

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Clinical Trials Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

Effects of Pentazocine Versus Lorazepam or Placebo on Manic Symptoms [Recruiting]
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study. We will examine whether pentazocine, an agent with kappa-opiate activity, decreases manic symptoms.

Effects of Pentazocine on Manic Symptoms [Active, not recruiting]
The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.

The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial [Not yet recruiting]
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.

Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty [Recruiting]
Postoperative pain after total knee arthroplasty (TKA) can be difficult to manage and may delay recovery. There are multimodal postoperative pain management after TKA, including intravenous opioids, epidural analgesia, peripheral nerve blocks or periarticular infiltration with local anesthetics. All of these treatments may lead to side effects such as nausea, headache, hypotension, urinary retention, partial motor block and infection of the knee. Therefore the investigators will compare three methods of postoperative analgesic after TKA by their efficiency and complication.

Comparison of Two Kinds of Postoperative Analgesia After Amputation [Recruiting]
Pain after amputation is a significant problem among amputees. Phantom limb pain may appear in up to 85% of patients and is usually resistant to a wide variety of treatments. It is believed that regional anesthesia, by preventing the establishment of central sensitization, may play a role in reducing the incidence of acute and chronic pain. Therefore the investigators will compare two methods of postoperative analgesic after after amputation by their efficiency and complication.

more trials >>


Page last updated: 2015-07-31

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