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Pentazocine and Acetaminophen (Pentazocine Hydrochloride / Acetaminophen) - Summary

 
 



BOXED WARNING
Hepatotoxicity
Acetaminophen has been associated with cases of acute liver failure, at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4000 milligrams per day, and often involve more than one acetaminophen-containing product.

 

SUMMARY

Pentazocine hydrochloride and acetaminophen tablets are a combination of pentazocine hydrochloride USP, equivalent to 25 mg base and acetaminophen USP, 650 mg. Pentazocine is a member of the benzazocine series (also known as the benzomorphan series).

Pentazocine hydrochloride and acetaminophen tablets are indicated for the relief of mild to moderate pain.


See all Pentazocine and Acetaminophen indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

Pediatric Pain Management
Source: Medscape Critical Care Headlines [2016.04.29]
What can be done to improve nurses' assessment and management of children's pain?
Pediatric Nursing

Friday Feedback: The Continuing Problem of Opioids and Pain
Source: MedPageToday.com - medical news plus CME for physicians [2016.04.29]
(MedPage Today) -- Can the FDA find a solution?

Friends better than morphine: Larger social networks release more pain-killing endorphin
Source: Anxiety / Stress News From Medical News Today [2016.04.28]
People with more friends have higher pain tolerance, Oxford University researchers have found.

How is the Federal Government's Pain Strategy Faring?
Source: MedPage Today Rheumatology [2016.04.26]
(MedPage Today) -- It's well-intentioned, but something is lacking, says Kenneth Lin, MD

Psychological issues behind increasing low back pain
Source: Psychology / Psychiatry News From Medical News Today [2016.04.25]
Low back pain is the most common symptom seen in primary care; the underlining injury is often enhanced by psychological and social stressors, write the authors of a Perspective published online by...

more news >>

Published Studies Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

[Postoperative nausea and vomiting after laparoscopic cholecystectomy under total intravenous anesthesia using propofol combined with fentanyl or pentazocine] [2007.11]
BACKGROUND: The aim of this study was to compare the incidence of postoperative nausea and vomiting (PONV) in propofol-anesthetized patients receiving either fentanyl or pentazocine as opioid supplement... CONCLUSIONS: The incidence of PONV in propofol-anesthetized patients receiving pentazocine as opioid supplement is not different from that in patients receiving fentanyl.

more studies >>

Clinical Trials Related to Pentazocine and Acetaminophen (Pentazocine / Acetaminophen)

Effects of Pentazocine Versus Lorazepam on Manic Symptoms [Completed]
Pilot data indicates that pentazocine decreases manic symptoms in hospitalized individuals. To follow up these initial findings, we plan to conduct a larger, more rigorous, double-blind study. We will examine whether pentazocine, an agent with kappa-opiate activity, decreases manic symptoms.

Effects of Pentazocine on Manic Symptoms [Completed]
The opiate neurotransmitter system is thought to be involved in many abnormal mood states. Some researchers have suggested that changes in this system may trigger the switch to/from manic and depressive states in bipolar disorder. One problem with most of the currently available opiate medications is that they can produce addiction/dependence. A particular kind of opiate medication known as kappa-opiates may be able to produce changes in this system with much less risk of addiction. This study looks at Talwin (a combination of pentazocine and naloxone), a medication which affects the kappa and mu opiate systems. The study will examine whether two doses of Talwin affect manic symptoms in people who have been admitted to the hospital. This study will give more information about the involvement of the opiate system in bipolar disorder, and give important information for use in developing new treatments.

Effects of a Kappa Agonist on Hot Flashes in Menopausal Women [Completed]

The Impact of Local Analgesia for Postoperative Analgesia in Posterior Thoracolumbar Operation [Completed]
Posterior thoracolumbar operation always chooses general anesthesia. Due to surgical trauma and rich periosteum and joint capsule innervation, patients after general anesthesia immediately feel acute pain. The use of appropriate postoperative analgesia in patients with thoracolumbar surgery is beneficial to postoperative recovery. Infusions of local anaesthetic via multilumen catheters that deliver directly to wound sites have been used for postoperative analgesia in procedures. Reducing the morbidity from both pain and nausea will make the mode of analgesia a better tolerated and more palatable option for patients. The aim of this study is to examine the effects of using local anaesthetic infusion catheters following posterior thoracolumbar surgery, and compares the outcomes of patients managed using intravenous analgesia pump infusion of systemic opioids.

The Feasibility of Different Doses of Etomidate Admixed With Propofol in Induced Abortion: A Randomized, Double Blind Controlled Trial [Not yet recruiting]
To explore the feasibility of different doses of etomidate admixed with propofol in induced abortion: a randomized, double blind controlled trial.

more trials >>


Page last updated: 2016-04-29

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