PENICILLIN V SUMMARY
Penicillin V Potassium for Oral Solution, USP
Penicillin V Potassium for Oral Solution, the potassium salt of penicillin V, monopotassium [2S-(2α,5α,6β)]-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo [3.2.
Penicillin V potassium is indicated in the treatment of mild to moderately severe infections due to penicillin G-sensitive microorganisms. Therapy should be guided by bacteriologic studies (including sensitivity tests) and by clinical response.
NOTE: Severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis should not be treated with penicillin V during the acute stage.
Indicated surgical procedures should be performed.
The following infections will usually respond to adequate dosage of penicillin V.
Streptococcal infections (without bacteremia). Mild-to-moderate infections of the upper respiratory tract, scarlet fever, and mild erysipelas.
NOTE: Streptococci in groups A, C, G, H, L, and M are very sensitive to penicillin. Other groups, including group D (enterococcus), are resistant.
Pneumococcal infections. Mild to moderately severe infections of the respiratory tract.
Staphylococcal infections –penicillin G-sensitive. Mild infections of the skin and soft tissues.
NOTE: Reports indicate an increasing number of strains of staphylococci resistant to penicillin G, emphasizing the need for culture and sensitivity studies in treating suspected staphylococcal infections.
Fusospirochetosis (Vincent’s gingivitis and pharyngitis)–Mild to moderately severe infections of the oropharynx usually respond to therapy with oral penicillin.
NOTE: Necessary dental care should be accomplished in infections involving the gum tissue.
Medical conditions in which oral penicillin therapy is indicated as prophylaxis:
For the prevention of recurrence following rheumatic fever and/or chorea: Prophylaxis with oral penicillin on a continuing basis has proven effective in preventing recurrence of these conditions.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Penicillin V Potassium for Oral Solution and other antibacterial drugs, Penicillin V Potassium for Oral Solution should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Published Studies Related to Penicillin V
Once-daily amoxicillin versus twice-daily penicillin V in group A beta-haemolytic streptococcal pharyngitis. [2008.06]
BACKGROUND: Rheumatic fever is a preventable chronic disease preceded by group A beta-haemolytic streptococcal (GABHS) pharyngitis. OBJECTIVE: To test the non-inferiority of once-daily (QD) oral amoxicillin to the recommended twice-daily (BID) oral penicillin V in GABHS pharyngitis... CONCLUSION: In this adequately powered study, once-daily oral amoxicillin is not inferior to twice-daily penicillin V for the treatment and eradication of GABHS in children with pharyngitis.
Comparative bioavailability study of two phenoxymethylpenicillin potassium tablet formulations in healthy volunteers. [2007.12]
CONCLUSION: Since the 90% CI for AUC0-t, AUC0-infinity and Cmax ratios were all within the 80 - 125% interval proposed by the US FDA and accepted by ANVISA, it was concluded that the Meracilina formulation (manufactured by AchA(c) S.A.) is bioequivalent to Pen-Ve-Oral (manufactured by Eurofarma) for both the rate and the extent of bioavailability.
Evaluation of phenoxymethylpenicillin treatment of acute otitis media in children aged 2-16. [2007.09]
OBJECTIVE: To study the clinical recovery from acute otitis media (AOM) in children, 2-16 years of age, managed with or without treatment with phenoxymethylpenicillin (PcV)... CONCLUSIONS: Our investigation supports that PcV treatment of AOM does not affect the recovery time or complication rates. PcV provided some symptomatic benefit in the treatment of AOM in otherwise healthy children, aged 2-16 years.
A randomized prospective controlled trial of antibiotic prophylaxis in intraoral bone-grafting procedures: preoperative single-dose penicillin versus preoperative single-dose clindamycin. [2006.05]
In this comparative study, 150 consecutive patients undergoing local intraoral bone grafting randomly received either an oral single dose of 600 mg clindamycin or 2 g of the penicillin phenethicillin 1 h before incision. Primary endpoint was wound infection at the receptor site within 8 weeks of surgery...
Comparison of a two- or three-week regimen and a review of treatment of erythema migrans with phenoxymethylpenicillin. 
BACKGROUND: A longer duration treatment is preferred in erythema migrans (EM) to prevent late complaints. OBJECTIVES: To determine whether 20 (20d-pt) or 14 days (14d-pt) of phenoxymethylpenicillin (PenV) have similar efficacy in treating EM and preventing further sequelae... CONCLUSION: A 2-week treatment regimen of PenV seems to be as effective as a 3-week course with no statistical differences for clinical and serological findings after treatment. Copyright (c) 2006 S. Karger AG, Basel.
Clinical Trials Related to Penicillin V
Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin [Terminated]
The purpose of this study is to examine whether oral challenge with penicillin for patients
with a known history of non-life threatening allergic reaction to penicillin is
well-tolerated irrespective of skin-testing results
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams [Recruiting]
This study aims to compare the readings of skin testing results in patients with suspected
penicillin allergy between in-house penicillin test preparation and commercial available
penicillin testing kit.
TELI TON - Telithromycin in Tonsillitis [Terminated]
This is a multinational, randomized (1: 1), double blind, double dummy, comparator-controlled,
2 parallel treatment group study in subjects from 6 months to < 13 years of age, with
Streptococcus pyogenes tonsillitis/pharyngitis (T/P).Each subject will receive either
telithromycin 25 mg/kg once daily for 5 days or penicillin V, 13. 3 mg/kg three times daily
for 10 days. Matching placebo for telithromycin and penicillin V will also be dispensed for 5
and 10 days respectively, to provide blinding to the different treatment regimens. A positive
rapid identification test for streptococcal Group A antigen will be required for all subjects
at Visit 1 (Day 1) for entry into the study. Throat swab specimens for bacterial culture,
identification, and antibiotic-susceptibility testing will be taken at Visits 1, 3 and 4.
Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia [Recruiting]
This study seeks to determine whether clinical outcome following initial treatment of severe
pneumonia with oral amoxicillin is as effective as the current standard benzyl penicillin.
The study will also provide an estimate of the proportion of Kenyan children with severe
pneumonia who fail treatment with a single antibiotic.
TELI TAD - Telithromycin in Tonsillitis in Adolescents and Adults [Terminated]
This is a multinational, randomized (1: 1), double blind, comparator-controlled, 2 parallel
treatment group study in subjects equal to or over 13 years of age, with Streptococcus
pyogenes tonsillitis/pharyngitis (T/P). Each subject will receive either telithromycin, 400
mg over-encapsulated tablets, 800 mg once daily for 5 days or penicillin V 250 mg
over-encapsulated tablets, 500 mg three times daily for 10days. Matching placebo capsules
will be dispensed to maintain the blind between the treatment groups. A positive rapid
identification test for streptococcal Group A antigen will be required for all subjects at
Visit 1 (Day 1) for entry into the study. Throat swab specimens for bacterial culture,
identification, and antibiotic-susceptibility testing will be taken at Visits 1, 3 and 4.
Reports of Suspected Penicillin V Side Effects
Stevens-Johnson Syndrome (7),
Oedema Peripheral (5),
Blindness Transient (5),
LIP Swelling (3),
Skin Exfoliation (3),
Tunnel Vision (3),
Oedema Mouth (3),
Skin Swelling (3), more >>
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Penicillin V has an overall score of 9. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Penicillin V review by 30 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || strep throat|
|Dosage & duration:|| || 200 milligrams (dosage frequency: twice a day) for the period of 10 days|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || The treatment effectively got rid of my infection and also alleviated my pain after taking twice(on day).|
|Side effects:|| || The only side effects were I felt a little sick if I took the pill on an empty stomach and I got diarrhea a couple of times|
|Comments:|| || After seeing my doctor I was prescribed Penicillin V and took it for ten days twice a day. |
Page last updated: 2008-06-22