PENICILLIN G SUMMARY
Penicillin G Potassium, USP is a natural penicillin.
Penicillin G Potassium Injection, USP is indicated in the treatment of serious infections caused by susceptible strains of the designated microorganisms in the conditions listed below. Appropriate culture and susceptibility tests should be done before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to penicillin G. Therapy with Penicillin G Potassium Injection, USP may be initiated before results of such tests are known when there is reason to believe the infection may involve any of the organisms listed below; however, once these results become available, appropriate therapy should be continued.
| CLINICAL INDICATION || INFECTING ORGANISM |
|Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis|| Streptococcus pyogenes (group A β-hemolytic streptococcus), other β-hemolytic streptococci including groups C, H, G, L and M, Streptococcus pneumoniae and Staphylococcus species (non-penicillinase producing strains)|
|Anthrax|| Bacillus anthracis|
|Actinomycosis (cervico-facial disease and thoracic and abdominal disease)|| Actinomyces israelii|
|Botulism (adjunctive therapy to antitoxin), gas gangrene, and tetanus (adjunctive therapy to human tetanus immune globulin)|| Clostridium species |
|Diphtheria (adjunctive therapy to antitoxin and prevention of the carrier state)|| Corynebacterium diphtheriae |
|Erysipelothrix endocarditis|| Erysipelothrix rhusiopathiae|
|Fusospirochetosis (severe infections of the oropharynx [Vincent’s], lower respiratory tract and genital area)|| Fusobacterium species and spirochetes|
|Listeria infections including meningitis and endocarditis|| Listeria monocytogenes |
|Pasteurella infections including bacteremia and meningitis|| Pasteurella multocida |
|Haverhill fever|| Streptobacillus moniliformis |
|Rat bite fever|| Spirillum minus or Streptobacillus moniliformis |
|Disseminated gonococcal infections|| Neisseria gonorrhoeae (penicillin-susceptible)|
|Syphilis (congenital and neurosyphilis)|| Treponema pallidum |
|Meningococcal meningitis and/or septicemia|| Neisseria meningitides |
|Gram-negative bacillary infections (bacteremias)|| Escherichia coli, Enterobacter aerogenes, Alcaligenes faecalis, salmonella , shigella and Proteus mirabilis, Penicillin G is not the drug of choice in the treatment of gram-negative bacillary infections.|
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Penicillin G Potassium Injection, USP and other antibacterial drugs, Penicillin G Potassium Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Published Studies Related to Penicillin G
Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. [2011.06]
BACKGROUND: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A beta -hemolytic streptococcal (GAS) pharyngitis... CONCLUSION: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.
Administration of perioperative penicillin reduces postoperative serum amyloid a response in horses being castrated standing. [2010.07]
OBJECTIVES: To compare postoperative inflammatory responses in horses administered perioperative procaine penicillin and those not administered penicillin using acute phase protein serum amyloid A (SAA) as a marker of inflammation. STUDY DESIGN: Randomized clinical trial. ANIMALS: Stallions (n=50) castrated under field conditions... CONCLUSIONS: Perioperative antimicrobial therapy reduced the postoperative SAA response, suggesting that bacteria were present in the surgical wound and contributed to inflammation after castration. Horses with elevated preoperative SAA concentrations developed infectious complications more often than horses with normal preoperative SAA concentrations. CLINICAL RELEVANCE: Administration of antimicrobials may be important in horses being castrated standing under field conditions. Increased SAA concentrations seem to be an indicator of increased surgical risk in horses and may be useful before elective surgery for planning.
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. [2010.06.01]
BACKGROUND: Syphilis remains an important source of morbidity worldwide. Long-acting penicillin is the only therapy currently recommended for syphilis in much of the world. Because of hesitation to use penicillin for fear of anaphylaxis, there is a need for an effective, well-tolerated alternative to penicillin for syphilis therapy... CONCLUSIONS: In this trial, the efficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine penicillin G for the treatment of early syphilis in persons without HIV infection.
Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. [2010.05]
AIM: We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS)... CONCLUSIONS: AMP and PEN combined with gentamicin have similar effectiveness in the empiric treatment of suspected neonatal EOS.
Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial. [2010.04]
CONCLUSIONS: Penicillin G potassium troches are effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of a single episode of MiRAU in this Chinese cohort. Few adverse effects were observed with this therapeutic approach. Copyright 2010 Mosby, Inc. All rights reserved.
Clinical Trials Related to Penicillin G
Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin [Terminated]
The purpose of this study is to examine whether oral challenge with penicillin for patients
with a known history of non-life threatening allergic reaction to penicillin is
well-tolerated irrespective of skin-testing results
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams [Recruiting]
This study aims to compare the readings of skin testing results in patients with suspected
penicillin allergy between in-house penicillin test preparation and commercial available
penicillin testing kit.
TELI TON - Telithromycin in Tonsillitis [Terminated]
This is a multinational, randomized (1: 1), double blind, double dummy, comparator-controlled,
2 parallel treatment group study in subjects from 6 months to < 13 years of age, with
Streptococcus pyogenes tonsillitis/pharyngitis (T/P).Each subject will receive either
telithromycin 25 mg/kg once daily for 5 days or penicillin V, 13. 3 mg/kg three times daily
for 10 days. Matching placebo for telithromycin and penicillin V will also be dispensed for 5
and 10 days respectively, to provide blinding to the different treatment regimens. A positive
rapid identification test for streptococcal Group A antigen will be required for all subjects
at Visit 1 (Day 1) for entry into the study. Throat swab specimens for bacterial culture,
identification, and antibiotic-susceptibility testing will be taken at Visits 1, 3 and 4.
Amoxicillin Versus Benzyl Penicillin for Treatment of Children Hospitalised With Severe Pneumonia [Recruiting]
This study seeks to determine whether clinical outcome following initial treatment of severe
pneumonia with oral amoxicillin is as effective as the current standard benzyl penicillin.
The study will also provide an estimate of the proportion of Kenyan children with severe
pneumonia who fail treatment with a single antibiotic.
A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals [Completed]
To provide information on the response of HIV infected, neurosyphilis patients to the
currently recommended treatment for neurosyphilis; to determine whether possible co-infection
with both HIV and syphilis makes more difficult the diagnosis of syphilis; to explore the
usefulness of an alternative treatment which, if effective, would permit outpatient treatment
for neurosyphilis that until now required prolonged hospitalization.
Studies suggest that syphilis treatment failures may be more common in HIV infected patients
than in patients without HIV infection and that treatment failures occur due to and/or are
displayed as central nervous system (CNS) involvement. Very little is known about the best
treatment course for neurosyphilis in patients who are also infected with HIV.
Reports of Suspected Penicillin G Side Effects
Pruritus Generalised (2),
Oedema Peripheral (2),
Blood Glucose Increased (2),
Drug Hypersensitivity (2),
Blood PH Increased (1),
Device Related Infection (1),
Death (1), more >>
Page last updated: 2011-12-09