PENICILLIN G SUMMARY
Penicillin G Potassium for Injection, USP is a natural penicillin. Penicillin G Potassium for Injection, USP is a sterile, pyrogen-free powder for reconstitution. Penicillin G Potassium for Injection, USP is an antibacterial agent intended for parenteral administration.
Therapy: Penicillin G Potassium for Injection, USP is indicated in the treatment of serious infections caused by susceptible strains of the designated microorganisms in the conditions listed below.
Appropriate culture and susceptibility tests should be done before treatment in order to isolate and identify organisms causing infection and to determine their susceptibility to penicillin G.
Therapy with penicillin G Potassium for Injection, USP may be indicated before results of such tests are known when there is reason to believe the infection may involve any of the organisms listed below, however, once these results become available, appropriate therapy should be continued.
|Septicemia, empyema, pneumonia, pericarditis, endocarditis, meningitis
Streptococcus pyogenes (group A
β-hemolytic streptococcus), other
β-hemolytic streptococci including
groups C,H,G,L and M, Streptococcus pneumoniae and Staphylococcus species (non-penicillinase producing strains)
|Actinomycosis (cervico-facial disease and thoracic and abdominal disease)
|Botulism (adjunctive therapy to antitoxin), gas gangrene, and tetanus (adjunctive therapy to human tetanus immune globulin)
|Diphtheria (adjunctive therapy to antitoxin and prevention of the carrier state)
|Fusospirochetosis (severe infections of the oropharynx [Vincents], lower respiratory tract and genital area)
Fusobacterium species and
|Listeria infections including meningitis and endocarditis
|Pasteurella infections including bacteremia and meningitis
|Rat bite fever
Spirillum minus or Streptobacillus
|Disseminated gonococcal infections
|Syphilis (congenital and neurosyphilis)
|Meningococcal meningitis and / or septicemia
Gram-negative bacillary infections (bacteremias)
Penicillin G is not the drug of choice in the treatment of gram-negative bacillary infections.
Gram -negative bacillary organisms (i.e. Enterobacteriaceae)
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Penicillin G Potassium for Injection, USP and other antibacterial drugs, Penicillin G Potassium for Injection, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Published Studies Related to Penicillin G
Treatment of streptococcal pharyngitis with once-daily amoxicillin versus intramuscular benzathine penicillin G in low-resource settings: a randomized controlled trial. [2011.06]
BACKGROUND: Primary prevention of acute rheumatic fever is achieved by proper antibiotic treatment of group A beta -hemolytic streptococcal (GAS) pharyngitis... CONCLUSION: If compliance is a major issue, a single dose of IM BPG may be preferable for treatment of GAS pharyngitis.
Administration of perioperative penicillin reduces postoperative serum amyloid a response in horses being castrated standing. [2010.07]
OBJECTIVES: To compare postoperative inflammatory responses in horses administered perioperative procaine penicillin and those not administered penicillin using acute phase protein serum amyloid A (SAA) as a marker of inflammation. STUDY DESIGN: Randomized clinical trial. ANIMALS: Stallions (n=50) castrated under field conditions... CONCLUSIONS: Perioperative antimicrobial therapy reduced the postoperative SAA response, suggesting that bacteria were present in the surgical wound and contributed to inflammation after castration. Horses with elevated preoperative SAA concentrations developed infectious complications more often than horses with normal preoperative SAA concentrations. CLINICAL RELEVANCE: Administration of antimicrobials may be important in horses being castrated standing under field conditions. Increased SAA concentrations seem to be an indicator of increased surgical risk in horses and may be useful before elective surgery for planning.
A phase III equivalence trial of azithromycin versus benzathine penicillin for treatment of early syphilis. [2010.06.01]
BACKGROUND: Syphilis remains an important source of morbidity worldwide. Long-acting penicillin is the only therapy currently recommended for syphilis in much of the world. Because of hesitation to use penicillin for fear of anaphylaxis, there is a need for an effective, well-tolerated alternative to penicillin for syphilis therapy... CONCLUSIONS: In this trial, the efficacy of azithromycin at a dosage of 2.0 g administered orally was equivalent to that of benzathine penicillin G for the treatment of early syphilis in persons without HIV infection.
Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. [2010.05]
AIM: We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS)... CONCLUSIONS: AMP and PEN combined with gentamicin have similar effectiveness in the empiric treatment of suspected neonatal EOS.
Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial. [2010.04]
CONCLUSIONS: Penicillin G potassium troches are effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of a single episode of MiRAU in this Chinese cohort. Few adverse effects were observed with this therapeutic approach. Copyright 2010 Mosby, Inc. All rights reserved.
Clinical Trials Related to Penicillin G
Penicillin and Metronidazole in Treatment of Peritonsillar Abscess [Completed]
Treatment of peritonsillar abscess varies. To study whether broad spectrum antibiotics are
required in addition to abscess drainage we perform a prospective, double blind,
placebo-controlled, randomised study on 200 adult patients with peritonsillar abscess. 100
patients are given penicillin and metronidazole and 100 patients get penicillin and placebo.
Recovery and recurrence and analyzed.
Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams [Completed]
This study aims to compare the readings of skin testing results in patients with suspected
penicillin allergy between in-house penicillin test preparation and commercial available
penicillin testing kit.
Evaluation of Skin Testing Reagents for Penicillin Allergy [Completed]
A self- or parent-reported history of penicillin allergy excludes approximately 10% of the
US population from receiving penicillin (Kerr 1994, Kagy, Blaiss 1998, Solensky et al. 2000,
Neugut et al. 2001). Yet approximately 80% of patients labeled as allergic to the
penicillins can safely take these antibiotics without fear of a life-threatening reaction
(Gadde et al. 1993, Macy et al. 1997). The outcomes of this erroneous classification of
patients include unnecessary denial of an effective and well-tolerated class of antibiotics,
which are often the treatment of choice.
The primary aim of skin testing with the Penicillin Skin Test Kit is to identify subjects at
very low risk of developing acute IgE-dependent reactions when given a penicillin or
cross-reacting drug. The negative predictive value (NPV) of skin testing is assessed by oral
challenge with a penicillin.
Oral Penicillin and Penicillin Levels in Venous Umbilical Cord Blood [Recruiting]
Pregnant,laboring women will receive 2 grams of oral penicillin V before delivery. At the
time of delivery of the infant, umbilical vein cord blood will be obtained from the
umbilical cord. These cord blood samples will be sent for bioassay of penicillin levels.
Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin [Terminated]
The purpose of this study is to examine whether oral challenge with penicillin for patients
with a known history of non-life threatening allergic reaction to penicillin is
well-tolerated irrespective of skin-testing results
Reports of Suspected Penicillin G Side Effects
Pruritus Generalised (2),
Oedema Peripheral (2),
Blood Glucose Increased (2),
Drug Hypersensitivity (2),
Blood PH Increased (1),
Device Related Infection (1),
Death (1), more >>
Page last updated: 2011-12-09