PCE (erythromycin particles in tablets) is an antibacterial product containing specially coated erythromycin base particles for oral administration. The coating protects the antibiotic from the inactivating effects of gastric acidity and permits efficient absorption of the antibiotic in the small intestine.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of PCE and other antibacterial drugs, PCE should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
PCE tablets are indicated in the treatment of infections caused by susceptible strains of the designated microorganisms in the diseases listed below:
Upper respiratory tract infections of mild to moderate degree caused by
Streptococcus pyogenes; Streptococcus pneumoniae; Haemophilus influenzae
(when used concomitantly with adequate doses of sulfonamides, since many strains of
are not susceptible to the erythromycin concentrations ordinarily achieved). (See appropriate sulfonamide labeling for prescribing information.)
Lower respiratory tract infections of mild to moderate severity caused by
Listeriosis caused by
Respiratory tract infections due to
Skin and skin structure infections of mild to moderate severity caused by
(resistant staphylococci may emerge during treatment).
Pertussis (whooping cough) caused by
Bordetella pertussis. Erythromycin is effective in eliminating the organism from the nasopharynx of infected individuals, rendering them noninfectious. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in exposed susceptible individuals.
Diphtheria: Infections due to
Corynebacterium diphtheriae. as an adjunct to antitoxin, to prevent establishment of carriers and to eradicate the organism in carriers.
Erythrasma--In the treatment of infections due to
Intestinal amebiasis caused by
(oral erythromycins only). Extraenteric amebiasis requires treatment with other agents.
Acute pelvic inflammatory disease caused by
Neisseria gonorrhoeae: Erythrocin® Lactobionate-I.V. (erythromycin lactobionate for injection, USP) followed by erythromycin base orally, as an alternative drug in treatment of acute pelvic inflammatory disease caused by
in female patients with a history of sensitivity to penicillin. Patients should have a serologic test for syphilis before receiving erythromycin as treatment of gonorrhea and a follow-up serologic test for syphilis after 3 months.
Erythromycins are indicated for treatment of the following infections caused by
Chlamydia trachomatis: conjunctivitis of the newborn, pneumonia of infancy, and urogenital infections during pregnancy. When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of uncomplicated urethral, endocervical, or rectal infections in adults due to
When tetracyclines are contraindicated or not tolerated, erythromycin is indicated for the treatment of nongonococcal urethritis caused by
Primary syphilis caused by
Treponema pallidum. Erythromycin (oral forms only) is an alternative choice of treatment for primary syphilis in patients allergic to the penicillins. In treatment of primary syphilis, spinal fluid should be examined before treatment and as part of the follow-up after therapy.
Legionnaires' Disease caused by
Legionella pneumophila. Although no controlled clinical efficacy studies have been conducted, in vitro
and limited preliminary clinical data suggest that erythromycin may be effective in treating Legionnaires' Disease.
Prevention of Initial Attacks of Rheumatic Fever--Penicillin is considered by the American Heart Association to be the drug of choice in the prevention of initial attacks of rheumatic fever (treatment of
infections of the upper respiratory tract e.g., tonsillitis, or pharyngitis).3 Erythromycin is indicated for the treatment of penicillin-allergic patients. The therapeutic dose should be administered for ten days.
Prevention of Recurrent Attacks of Rheumatic Fever--Penicillin or sulfonamides are considered by the American Heart Association to be the drugs of choice in the prevention of recurrent attacks of rheumatic fever. In patients who are allergic to penicillin and sulfonamides, oral erythromycin is recommended by the American Heart Association in the long-term prophylaxis of streptococcal pharyngitis (for the prevention of recurrent attacks of rheumatic fever).3
Media Articles Related to PCE (Erythromycin)
Study links contaminated water to pregnancy complications
Source: Pregnancy / Obstetrics News From Medical News Today [2014.10.03]
Prenatal exposure to tetrachloroethylene (PCE) in drinking water may increase the risk of stillbirth and placental abruption, according to a new study led by a Boston University School of Public...
Antibiotic resistance: Bacterial defense policies
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today [2014.10.15]
High-resolution cryo-electron microscopy has now revealed in unprecedented detail the structural changes in the bacterial ribosome which results in resistance to the antibiotic erythromycin.
Published Studies Related to PCE (Erythromycin)
Randomized double-blind crossover study to determine the effects of erythromycin
on small intestinal nutrient absorption and transit in the critically ill. 
on small intestinal nutrient absorption and transit in the critically ill... CONCLUSIONS: Acute administration of erythromycin increases small intestinal
A comparison between the effectiveness of erythromycin, single-dose clarithromycin and topical fusidic acid in the treatment of erythrasma. [2011.09.18]
Abstract Although erythrasma is a superficial skin infection, there is no consensus on the treatment model of erythrasma... Conclusion: Topical fusidic acid proved to be the most effective treatment; however, clarithromycin therapy may be an alternative regimen in the treatment of erythrasma because of its efficiency and better patient's compliance.
[Comparison of maternal and perinatal outcomes in the conservative treatment preterm premature membrane rupture between the use of erythromycin and clindamycin]. [2011.07]
BACKGROUND: premature rupture of membranes occurs between 5 and 15% of pregnancies, of these, 10% occurs at term and preterm 2 to 3.5%. OBJECTIVE: To compare maternal and perinatal outcomes from the use of erythromycin or clindamycin in women with preterm premature rupture of membranes with conservative treatment at the Regional General Hospital No. 36... CONCLUSIONS: comparing the maternal and perinatal outcomes with conservative management of premature rupture of membranes, results were better in the group treated with erythromycin. It is not possible to prove it statistically because of the sample size.
Erythromycin infusion or gastric lavage for upper gastrointestinal bleeding: a multicenter randomized controlled trial. [2011.06]
STUDY OBJECTIVE: The quality of endoscopy depends on the quality of upper gastrointestinal tract preparation. We determine whether in acute upper gastrointestinal bleeding the frequency of satisfactory stomach visualization was different after intravenous erythromycin, a nasogastric tube with gastric lavage, or both... CONCLUSION: In acute upper gastrointestinal bleeding, administration of intravenous erythromycin provides satisfactory endoscopic conditions, without the need for a nasogastric tube and gastric lavage. Copyright (c) 2011 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.
A controlled trial of erythromycin and UDCA in premature infants during parenteral nutrition in minimizing feeding intolerance and liver function abnormalities. [2011.05.12]
Objective:To compare the effectiveness of oral erythromycin versus ursodeoxycholic acid (UDCA) treatment in preventing feeding intolerance and liver function abnormalities.Study Design:A prospective, double blind, randomized, controlled trial in which three groups of preterm infants (birth weight <1500 g) were randomized to erythromycin (12.5 mg kg(-1) per day), UDCA (5 mg kg(-1) every 6 h) or placebo treatment...
Clinical Trials Related to PCE (Erythromycin)
Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC) [Recruiting]
Bone-marrow-derived progenitor cells (EPCS) play an important role in neovascularization and
tumor growth. In lung cancer, angiogenesis is an important event in mechanisms of tumor
proliferation and metastasis. Recent evidences suggest that EPCS can be recruited and
differentiate in mature endothelial cells to form new blood vessels. The role of EPCs in
NSCLC is unclear. In contrast, angiogenic drugs are proposed combined to systemic
chemotherapy in NSCLC. The aim of this study is to identify EPCs in peripheral blood from
patients with NSCLC, by comparison to Chronic Pulmonary Obstructive Disease (COPD), an
Evaluation of Oral Lipid Ingestion in Relation to Ovarian Androgen Secretion in Polycystic Ovary Syndrome (PCOS) [Recruiting]
The purpose of this study is to determine the relationship between lipid-induced
inflammation and ovarian androgen secretion in women with polycystic ovary syndrome (PCOS);
and to examine the effect of salsalate and polygonum cuspidatum extract (PCE) containing
resveratrol on lipid-induced inflammation, ovarian androgen secretion, body composition and
ovulation in a subset of normal weight women with PCOS.
Effectiveness of Nursing Intervention on Caregivers [Not yet recruiting]
The purpose of this study is to evaluate the effectiveness of a structured nursing
intervention (PCE), including two types of intervention defined in the literature (coping
strategies promoting social support and empowerment through health education), which has an
effect on the perceived quality of life for the caregiver, when compared with conventional
intervention or non-support.
TempTouch IR Thermometry & Diabetic Patient Self-Care [Completed]
Foot ulcers develop in diabetics with neuropathy because of cumulative injury over the course
of several days. These patients do not feel pain, and do not recognize their foot is being
injured until a wound develops. Areas about to ulcerate become inflamed and “hot spots” can
be identified. This study’s purpose is to evaluate the effectiveness of a home infrared
temperature probe designed to forewarn patients that an area on the foot is inflamed so they
can take preventive measures. The study will evaluate the incidence of diabetic foot ulcers
among high-risk patients, evaluate the cost of home temperature monitoring compared to
standard therapy, and evaluate patient satisfaction. 180 diabetics at high-risk of having
foot complications will be randomized into 3 treatment arms: 1) standard therapy consisting
of regular foot care; 2) standard therapy plus recording of a structured foot evaluation
using a hand mirror; and 3) standard therapy plus infrared home temperature assessment to
identify âhot spots. â Device patients will measure temperatures at 6 sites on the foot each
day. When temperatures are elevated >4Â°F patients will contact the research nurse and
decrease activity. The primary study outcome will be incident foot ulcers and Charcot
Nutrition Intervention in Drug Naive HIV-infected Kenyan Women and Their Children [Recruiting]
Many of the 28 million people with immunodeficiency virus (HIV) and acquired
immunodeficiency syndrome (AIDS) estimated to be living in sub-Saharan Africa also suffer
from malnutrition. Reproductive age women, their infants and young children are among the
most vulnerable for malnutrition and progression of HIV to AIDS and mortality is increased
in the malnourished, as seen in Eastern and Southern Africa. The HIV Nutrition Project
(HNP) research evaluates the effect of protein and micronutrients in meat on the health and
nutritional well being of Kenyan women living with HIV in rural Kenya and the health and
development of their children, by means of a randomized nutrition intervention. We will
determine if meat in the diets of HIV- infected women and their children (1) protects the
immune system and prevents severe infection, (2) prevents the loss of body mass and enhances
the quality of life among drug naÃ¯ve women not yet ill enough to warrant antiretroviral
drugs and (3) positively impacts growth and development of vulnerable children of the
HIV-infected women when compared to those given supplements with the same amount of energy
but with either soya or wheat protein. The intervention food with beef protein provides
significant vitamin B12, lysine and bio-available iron, zinc and selenium when compared to
the soya and wheat supplements. Deficiencies of these nutrients may hasten HIV disease
The findings from our project may have implications for the development of initiatives that
are either sustainable or subsidized by the local, regional and/or global economies that
ensure that all HIV-infected individuals have access to adequate nutrition support that
includes foods that provide enough nutrients that are needed to optimize health and
well-being. The knowledge gained may significantly impact other populations at high risk for
decreased immune function such as those with tuberculosis and malaria.
This is a 3 arm randomized design where 225 HIV-infected rural Kenyan mothers with a CD4
between 250 and 500, WHO Stage 1 or 2, and with no co-existing infections, receive with
their child, a nutrition biscuit supplement daily (5 days/week) for 12 months. These women
are not yet ill enough to warrant treatment with antiretroviral drugs in Kenya and therefore
a food intervention may keep them healthy longer and delay the need for drugs.
Page last updated: 2014-10-15